Supramolecular protein engineering: Design of zinc-stapled insulin hexamers as a long acting depot

Journal of Biological Chemistry

Volumn 285, Issue 16, 2010, Pages 11755-11759

  Phillips, Nelson B ^a   Wan, Zhu Li ^a   Whittaker, Linda ^a   Hu, Shi Quan ^a   Huang, Kun ^a   Hua, Qing Xin ^a   Whittaker, Jonathan ^a   Ismail Beigi, Faramarz ^a   Weiss, Michael A ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL PROPERTIES; CANCER RISK; ELECTROSTATIC EFFECT; GLYCEMIC CONTROL; HELICAL SURFACES; HEXAMERS; INSULIN RECEPTORS; INSULIN-LIKE GROWTH FACTOR RECEPTORS; ISOELECTRIC PRECIPITATION; MITOGENIC; NEUTRAL PH; PHARMACOLOGICAL PROPERTIES; PROTEIN ASSEMBLY; PROTEIN ENGINEERING; TIME COURSE; ZINC IONS;

BIOCHEMICAL ENGINEERING; CRYSTAL STRUCTURE; FUNCTIONAL POLYMERS; GENETIC ENGINEERING; INSULIN; IONS; PRECIPITATION (CHEMICAL); PROTEINS; RAT CONTROL; SUPRAMOLECULAR CHEMISTRY; SURFACE STRUCTURE; ZINC;

PH EFFECTS;

INSULIN; INSULIN GLARGINE; INSULIN RECEPTOR; SOMATOMEDIN RECEPTOR; ZINC ION;

ALPHA HELIX; AMINO ACID SUBSTITUTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER RISK; CHEMICAL MODIFICATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DIABETES MELLITUS; DRUG DESIGN; DRUG FORMULATION; DRUG RECEPTOR BINDING; DRUG SAFETY; DRUG SPECIFICITY; GLYCEMIC CONTROL; ISOELECTRIC POINT; MALE; NANOBIOTECHNOLOGY; NONHUMAN; PH; PRECIPITATION; PRIORITY JOURNAL; PROTEIN ENGINEERING; RAT; SIGNAL TRANSDUCTION; STATIC ELECTRICITY; SUPRAMOLECULAR CHEMISTRY;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; DELAYED-ACTION PREPARATIONS; DRUG DESIGN; HUMANS; INSULIN; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROTEIN ENGINEERING; PROTEIN STRUCTURE, SECONDARY; RATS; STATIC ELECTRICITY; ZINC;

RATTUS;

EID: 77951245183     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.C110.105825     Document Type: Article

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