Improved pharmacokinetic and pharmacodynamic profile of rapid-acting insulin using needle-free jet injection technology

Diabetes Care

Volumn 34, Issue 8, 2011, Pages 1804-1808

  Engwerda, Elsemiek E C ^a   Abbink, Evertine J ^a   Tack, Cees J ^a   De Galan, Bastiaan E ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN ASPART; PLACEBO; SHORT ACTING INSULIN;

ADULT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG EFFICACY; FEMALE; GLUCOSE BLOOD LEVEL; GLUCOSE CLAMP TECHNIQUE; HORMONE ACTION; HUMAN; HUMAN EXPERIMENT; INFUSION RATE; INSULIN RELEASE; JET INJECTION; MALE; MAXIMUM PLASMA CONCENTRATION; NORMAL HUMAN; PHARMACODYNAMICS; RANDOMIZED CONTROLLED TRIAL; TIME TO MAXIMUM PLASMA CONCENTRATION; BLOOD; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; DRUG EFFECT;

ADULT; BLOOD GLUCOSE; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; FEMALE; GLUCOSE CLAMP TECHNIQUE; HUMANS; INJECTIONS, JET; INSULIN, SHORT-ACTING; MALE; YOUNG ADULT;

EID: 84856019647     PISSN: 01495992     EISSN: 19355548     Source Type: Journal    
DOI: 10.2337/dc11-0182     Document Type: Article

References (22)

1. Mitragotri S. Current status and future prospects of needle-free liquid jet injectors. Nat Rev Drug Discov 2006;5:543-548 (Pubitemid 43971188)
2. Weller C, Linder M. Jet injection of insulin vs the syringe-and-needle method. JAMA 1966;195:844-847
3. Taylor R, Home PD, Alberti KG. Plasma free insulin profiles after administration of insulin by jet and conventional syringe injection. Diabetes Care 1981;4:377-379 (Pubitemid 12201587)
4. Pehling GB, Gerich JE. Comparison of plasma insulin profiles after subcutaneous administration of insulin by jet spray and conventional needle injection in patients with insulin-dependent diabetes mellitus. Mayo Clin Proc 1984;59:751-754 (Pubitemid 15210679)
5. Hallé JP, Lambert J, Lindmayer I, et al. Twice-daily mixed regular and NPH insulin injections with new jet injector versus conventional syringes: pharmacokinetics of insulin absorption. Diabetes Care 1986;9:279-282 (Pubitemid 16060914)
6. Malone JI, Lowitt S, Grove NP, Shah SC. Comparison of insulin levels after injection by jet stream and disposable insulin syringe. Diabetes Care 1986;9:637-640 (Pubitemid 17208945)
7. Kerum G, Profozić V, Granić M, Skrabalo Z. Blood glucose and free insulin levels after the administration of insulin by conventional syringe or jet injector in insulin treated type 2 diabetics. Horm Metab Res 1987;19:422-425 (Pubitemid 17139220)
8. Lucas A, Ribas L, Salinas I, Audí L, Sanmartí A, Foz M. Insulin levels after injection by jet stream and disposable syringe. Diabetes Care 1988;11:298-299
9. Sarno MJ, Bell J, Edelman SV. Pharmacokinetics and glucodynamics of rapid-, short-, and intermediate-acting insulins: comparison of jet injection to needle syringe. Diabetes Technol Ther 2002;4:863-866 (Pubitemid 36169241)
10. Mudaliar SR, Lindberg FA, Joyce M, et al. Insulin aspart (B28 asp-insulin): a fastacting analog of human insulin: absorption kinetics and action profile compared with regular human insulin in healthy nondiabetic subjects. Diabetes Care 1999;22:1501-1506 (Pubitemid 29418246)
11. Howey DC, Bowsher RR, Brunelle RL, Woodworth JR. [Lys(B28), Pro(B29)]-human insulin. A rapidly absorbed analogue of human insulin. Diabetes 1994; 43:396-402 (Pubitemid 24064246)
12. Heise T, Weyer C, Serwas A, et al. Time-action profiles of novel premixed preparations of insulin lispro and NPL insulin. Diabetes Care 1998;21:800-803 (Pubitemid 28487075)
13. DeFronzo RA, Tobin JD, Andres R. Glucose clamp technique: a method for quantifying insulin secretion and resistance. Am J Physiol 1979;237:E214-E223 (Pubitemid 9249478)
14. Luijf YM, DeVries JH. Dosing accuracy of insulin pens versus conventional syringes and vials. Diabetes Technol Ther 2010;12 (Suppl. 1):S73-S77
15. Thurman JE. Insulin pen injection devices for management of patients with type 2 diabetes: considerations based on an endocrinologist's practical experience in the United States. Endocr Pract 2007;13: 672-678
16. Heinemann L, Anderson JH Jr. Measurement of insulin absorption and insulin action. Diabetes Technol Ther 2004;6:698-718 (Pubitemid 39383074)
17. Abumrad NN, Rabin D, Diamond MP, Lacy WW. Use of a heated superficial hand vein as an alternative site for the measurement of amino acid concentrations and for the study of glucose and alanine kinetics in man. Metabolism 1981;30:936-940 (Pubitemid 11057495)
18. Abbink EJ, van der Wal PS, Sweep CG, Smits P, Tack CJ. Compared to glibenclamide, repaglinide treatment results in a more rapid fall in glucose level and betacell secretion after glucose stimulation. Diabetes Metab Res Rev 2004;20:466-471 (Pubitemid 40028647)
19. Abbink EJ, Walker AJ, van der Sluijs HA, Tack CJ, Smits P. No role of calcium- and ATP-dependent potassium channels in insulin-induced vasodilation in humans in vivo. Diabetes Metab Res Rev 2002;18: 143-148 (Pubitemid 34467304)
20. Asakura T, Seino H, Nakano R, et al. A comparison of the handling and accuracy of syringe and vial versus prefilled insulin pen (FlexPen). Diabetes Technol Ther 2009; 11:657-661
21. Bremseth DL, Pass F. Delivery of insulin by jet injection: recent observations. Diabetes Technol Ther 2001;3:225-232 (Pubitemid 32651958)
22. 1(c) and mean blood glucose show stronger associations with cardiovascular disease risk factors than do postprandial glycaemia or glucose variability in persons with diabetes: the A1C-Derived Average Glucose (ADAG) study. Diabetologia 2011;54:69-72