Effect of cutaneous blood flow on absorption of insulin: A methodological study in healthy male volunteers

International Journal of Physiology, Pathophysiology and Pharmacology

Volumn 3, Issue 4, 2011, Pages 257-265

  Jakobsen, Lydia A ^a   Jensen, Anne ^a   Larsen, Lars E ^a   Sørensen, Morten R ^a   Hoeck, Hans Christian ^b   Arendt Nielsen, Lars ^a   Gazerani, Parisa ^a  

^a AALBORG UNIVERSITY   (Denmark)

^b CENTER FOR CLINICAL AND BASIC RESEARCH   (Denmark)

Author keywords

Absorption; Actrapid ; Insulin; Local heat; Skin perfusion; Subcutaneous depot

Indexed keywords

GLUCOSE; INSULIN; NEUTRAL INSULIN;

ADULT; ARTICLE; BLOOD SAMPLING; CAUCASIAN; DRUG ABSORPTION; DRUG EFFECT; GLUCOSE BLOOD LEVEL; HEAT; HUMAN; HUMAN EXPERIMENT; INSULIN BLOOD LEVEL; LASER DOPPLER FLOWMETRY; MALE; METHODOLOGY; NORMAL HUMAN; RANDOMIZED CONTROLLED TRIAL; SKIN BLOOD FLOW; TISSUE PERFUSION;

EID: 83455219308     PISSN: None     EISSN: 19448171     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. Kimura T and Higaki K. Gastrointestinal transit and drug absorption. Biol Pharm Bull 2002; 25: 149-164.
2. Woodley JF. Enzymatic barriers for GI peptide and protein delivery. Crit Rev Ther Drug Carrier Syst 1994; 11: 61-95.
3. Malik DK, Baboota S, Ahuja A, Hasan S and Ali J. Recent advances in protein and peptide drug delivery systems. Curr Drug Deliv 2007; 4: 141-151.
4. Chen JW, Christiansen JS and Lauritzen T. Limitations to subcutaneous insulin administration in type 1 diabetes. Diabetes Obes Metab 2003; 5: 223-233.
5. [Guerci B and Sauvanet JP. Subcutaneous insulin: pharmacokinetic variability and glycemic variability. Diabetes Metab 2005; 31: S47-S424.
6. Scheindlin S. Transdermal drug delivery: PAST, PRESENT, FUTURE. Mol Interv 2004; 4: 308 312.
7. Vanakoski J and Seppala T. Heat exposure and drugs. A review of the effects of hyperthermia on pharmacokinetics. Clin Pharmacokinet 1998; 34: 311-322.
8. Koivisto VA, Fortney S, Hendler R and Felig P. A rise in ambient temperature augments insulin absorption in diabetic patients. Metabolism 1981; 30: 402-405.
9. Koivisto VA. Sauna-induced acceleration in insulin absorption. Br Med J 1980; 281: 621 622.
10. Koivisto VA. Influence of heat on insulin absorption: different effects on amorphous and soluble insulins. Acta Diabetol Lat 1983; 20: 175-178.
11. Cuppers HJ, Berchtold P and Berger M. Saunainduced acceleration in insulin absorption. Br Med J 1980; 281: 307.
12. Hull W. Heat-Enhanced Transdermal Drug Delivery: A Survey Paper. The journal of applied research in clinical and experimental therapeutics 2002; 2:1-9.
13. Sindelka G, Heinemann L, Berger M, Frenck W and Chantelau E. Effect of insulin concentration, subcutaneous fat thickness and skin temperature on subcutaneous insulin absorption in healthy subjects. Diabetologia 1994; 37: 377-380.
14. Raz I, Weiss R, Yegorchikov Y, Bitton G, Nagar R and Pesach B. Effect of a local heating device on insulin and glucose pharmacokinetic profiles in an open-label, randomized, twoperiod, one-way crossover study in patients with type 1 diabetes using continuous subcutaneous insulin infusion. Clin Ther 2009; 31: 980-987.
15. Home PD, Barriocanal L and Lindholm A. Comparative pharmacokinetics and pharmacodynamics of the novel rapid-acting insulin analogue, insulin aspart, in healthy volunteers. Eur J Clin Pharmacol 1999; 55: 199-203.
16. Kaku K, Matsuda M, Urae A and Irie S. Phar macokinetics and pharmacodynamics of insulin aspart, a rapid-acting analog of human insulin, in healthy Japanese volunteers. Diabetes Res Clin Pract 2000; 49: 119-126.
17. Siekmann H. Recommended maximum temperatures for touchable surfaces. Appl Ergon 1990; 21: 69-73.
18. Eun HC. Evaluation of skin blood flow by laser Doppler flowmetry. Clin Dermatol 1995; 13: 337-347.
19. Choi CM and Bennett RG. Laser Dopplers to determine cutaneous blood flow. Dermatol Surg 2003; 29: 272-280.
20. Wright CI, Kroner CI and Draijer R. Noninvasive methods and stimuli for evaluating the skin's microcirculation. J Pharmacol Toxicol Methods 2006; 54: 1-25.
21. Lima A and Bakker J. Noninvasive monitoring of peripheral perfusion. Intensive Care Med 2005; 31: 1316-1326.
22. Johnson JM and Kellogg DL, Jr. Thermoregulatory and thermal control in the human cutaneous circulation. Front Biosci (Schol Ed) 2: 825 853.
23. Gazerani P and Arendt-Nielsen L. Cutaneous vasomotor reactions in response to controlled heat applied on various body regions of healthy humans: evaluation of time course and application parameters. Int J Physiol Pathophysiol Pharmacol 2011; 3: 202-209.
24. Nucci G and Cobelli C. Models of subcutaneous insulin kinetics. A critical review. Comput Methods Programs Biomed 2000; 62: 249 257.
25. Polaschegg E. Effect of physicochemical variables of regular insulin formulations on their absorption from the subcutaneous tissue. Diabetes Res Clin Pract 1998; 40: 39-44.
26. Petersen KK, Rousing ML, Jensen C, Arendt Nielsen L and Gazerani P. Effect of local controlled heat on transdermal delivery of nicotine. Int J Physiol Pathophysiol Pharmacol 2011; 3: 236-242.
27. Braverman IM. The cutaneous microcirculation. J Investig Dermatol Symp Proc 2000; 5: 3 9.