A comparison of the biological activities of human osteoblast hFOB1.19 between iron excess and iron deficiency

Biological Trace Element Research

Volumn 150, Issue 1-3, 2012, Pages 487-495

  Zhao, Guo Yang ^a   Zhao, Li Ping ^a   He, Yin Feng ^a   Li, Guang Fei ^a   Gao, Chao ^a   Li, Kai ^a   Xu, You Jia ^a  

^a SOOCHOW UNIVERSITY   (China)

Author keywords

Deferoxamine; Iron ion; Mineralization; Osteoblast; Proliferation

Indexed keywords

ALKALINE PHOSPHATASE; COLLAGEN TYPE 1; DEFEROXAMINE; FERRIC AMMONIUM CITRATE; IRON; OSTEOCALCIN; REACTIVE OXYGEN METABOLITE;

APOPTOSIS; ARTICLE; BONE DEVELOPMENT; BONE MINERALIZATION; CALCIFICATION; CELL FUNCTION; CELL LEVEL; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IN VITRO STUDY; IRON DEFICIENCY; IRON OVERLOAD; OSTEOBLAST; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ALKALINE PHOSPHATASE; ANEMIA, IRON-DEFICIENCY; APOPTOSIS; CALCIFICATION, PHYSIOLOGIC; CELL LINE; CELL PROLIFERATION; COLLAGEN TYPE I; DEFEROXAMINE; DIETARY SUPPLEMENTS; FERRIC COMPOUNDS; GENE EXPRESSION REGULATION; HORMESIS; HUMANS; IRON; IRON OVERLOAD; OSTEOBLASTS; OSTEOCALCIN; OSTEOGENESIS; QUATERNARY AMMONIUM COMPOUNDS; REACTIVE OXYGEN SPECIES; SIDEROPHORES;

EID: 84870681571     PISSN: 01634984     EISSN: 15590720     Source Type: Journal    
DOI: 10.1007/s12011-012-9511-9     Document Type: Article

References (37)

1. Anderson GJ, Frazer DM, McLaren GD (2009) Iron absorption and metabolism. Curr Opin Gastroenterol 25(2):129-135. doi: 10.1097/MOG.0b013e32831ef1f7
2. Stangl GI, Kirchgessner M (1998) Different degrees of moderate iron deficiency modulate lipid metabolism of rats. Lipids 33(9):889-895. doi: 10.1007/s11745-998-0285-8
3. Galaris D, Mantzaris M, Amorgianiotis C (2008) Oxidative stress and aging: the potential role of iron. Hormones (Athens) 7(2):114-122
4. Tuomainen T-P, Loft S, Nyyssonen K, Punnonen K, Salonen JT, Poulsen HE (2007) Body iron is a contributor to oxidative damage of DNA. Free Radic Res 41(3):324-328. doi: 10.1080/10715760601091642
5. Weinberg ED (2009) Iron availability and infection. Biochim Biophys Acta 1790(7):600-605. doi: 10.1016/j.bbagen.2008.07.002
6. Weinberg ED (2006) Iron loading: a risk factor for osteoporosis. Biometals 19(6):633-635. doi: 10.1007/s10534-006-9000-8, An international journal on the role of metal ions in biology, biochemistry, and medicine
7. Weinberg ED (2008) Role of iron in osteoporosis. Pediatr Endocrinol Rev 6(Suppl 1):81-85
8. Guggenbuhl P, Deugnier Y, Boisdet JF, Rolland Y, Perdriger A, Pawlotsky Y, Chales G (2005) Bone mineral density in men with genetic hemochromatosis and HFE gene mutation. Osteoporos Int 16(12):1809-1814. doi: 10.1007/s00198-005- 1934-0, A journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
9. Morabito N, Russo GT, Gaudio A, Lasco A, Catalano A, Morini E, Franchina F, Maisano D, La Rosa M, Plota M, Crifo A, Meo A, Frisina N (2007) The lively cytokines network in beta-thalassemia major-related osteoporosis. Bone 40(6):1588-1594. doi: 10.1016/j.bone.2007.02.020
10. Sarrai M, Duroseau H, D'Augustine J, Moktan S, Bellevue R (2007) Bone mass density in adults with sickle cell disease. Br J Haematol 136(4):666-672. doi: 10.1111/j.1365-2141.2006.06487.x
11. Skordis N, Toumba M (2011) Bone disease in thalassaemia major: recent advances in pathogenesis and clinical aspects. Pediatr Endocrinol Rev 8(Suppl 2):300-306
12. Valenti L, Varenna M, Fracanzani AL, Rossi V, Fargion S, Sinigaglia L (2009) Association between iron overload and osteoporosis in patients with hereditary hemochromatosis. Osteoporos Int 20(4):549-555. doi: 10.1007/s00198-008-0701-4
13. Isomura H, Fujie K, Shibata K, Inoue N, Iizuka T, Takebe G, Takahashi K, Nishihira J, Izumi H, Sakamoto W (2004) Bone metabolism and oxidative stress in postmenopausal rats with iron overload. Toxicology 197(2):93-100. doi: 10.1016/j.tox.2003.12.006
14. Kudo H, Suzuki S, Watanabe A, Kikuchi H, Sassa S, Sakamoto S (2008) Effects of colloidal iron overload on renal and hepatic siderosis and the femur in male rats. Toxicology 246(2-3):143-147. doi: 10.1016/j.tox.2008.01.004
15. Tsay J, Yang Z, Ross FP, Cunningham-Rundles S, Lin H, Coleman R, Mayer-Kuckuk P, Doty SB, Grady RW, Giardina PJ, Boskey AL, Vogiatzi MG (2010) Bone loss caused by iron overload in a murine model: importance of oxidative stress. Blood 116(14):2582-2589. doi: 10.1182/blood-2009-12-260083
16. Abraham R, Walton J, Russell L, Wolman R, Wardley-Smith B, Green JR, Mitchell A, Reeve J (2006) Dietary determinants of post-menopausal bone loss at the lumbar spine: a possible beneficial effect of iron. Osteoporos Int 17(8):1165-1173. doi: 10.1007/s00198-005-0033-6
17. Maurer J, Harris MM, Stanford VA, Lohman TG, Cussler E, Going SB, Houtkooper LB (2005) Dietary iron positively influences bone mineral density in postmenopausal women on hormone replacement therapy. J Nutr 135(4):863-869
18. Katsumata S, Tsuboi R, Uehara M, Suzuki K (2006) Dietary iron deficiency decreases serum osteocalcin concentration and bone mineral density in rats. Biosci Biotechnol Biochem 70(10):2547-2550
19. Katsumata SI, Katsumata-Tsuboi R, Uehara M, Suzuki K (2009) Severe iron deficiency decreases both bone formation and bone resorption in rats. J Nutr 139(2):238-243. doi: 10.3945/jn.108.093757
20. Doyard M, Fatih N, Monnier A, Island ML, Aubry M, Leroyer P, Bouvet R, Chales G, Mosser J, Loreal O, Guggenbuhl P (2012) Iron excess limits HHIPL-2 gene expression and decreases osteoblastic activity in human MG-63 cells. Osteoporos Int. doi: 10.1007/s00198-011-1871-z, A journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
21. Messer JG, Kilbarger AK, Erikson KM, Kipp DE (2009) Iron overload alters iron-regulatory genes and proteins, down-regulates osteoblastic phenotype, and is associated with apoptosis in fetal rat calvaria cultures. Bone 45(5):972-979. doi: 10.1016/j.bone.2009.07.073
22. Yamasaki K, Hagiwara H (2009) Excess iron inhibits osteoblast metabolism. Toxicol Lett 191(2-3):211-215. doi: 10.1016/j.toxlet.2009.08.023
23. Messer JG, Cooney PT, Kipp DE (2010) Iron chelator deferoxamine alters iron-regulatory genes and proteins and suppresses osteoblast phenotype in fetal rat calvaria cells. Bone 46(5):1408-1415. doi: 10.1016/j.bone.2010.01.376
24. Garcia JJ, Martinez-Ballarin E, Millan-Plano S, Allue JL, Albendea C, Fuentes L, Escanero JF (2005) Effects of trace elements on membrane fluidity. J Trace Elem Med Biol 19(1):19-22. doi: 10.1016/j.jtemb.2005.07.007
25. Jomova K, Valko M (2011) Advances in metal-induced oxidative stress and human disease. Toxicology 283(2-3):65-87. doi: 10.1016/j.tox.2011.03.001
26. Fatokun AA, Stone TW, Smith RA (2008) Responses of differentiated MC3T3-E1 osteoblast-like cells to reactive oxygen species. Eur J Pharmacol 587(1-3):35-41. doi: 10.1016/j.ejphar.2008.03.024
27. Mody N, Parhami F, Sarafian TA, Demer LL (2001) Oxidative stress modulates osteoblastic differentiation of vascular and bone cells. Free Radic Biol Med 31(4):509-519
28. Kicic A, Chua AC, Baker E (2001) Effect of iron chelators on proliferation and iron uptake in hepatoma cells. Cancer 92(12):3093-3110
29. Zarjou A, Jeney V, Arosio P, Poli M, Zavaczki E, Balla G, Balla J (2010) Ferritin ferroxidase activity: a potent inhibitor of osteogenesis. J Bone Miner Res: Off J Am Soc Bone Miner Res 25(1):164-172. doi: 10.1359/jbmr.091002
30. Cornish J, Callon KE, Naot D, Palmano KP, Banovic T, Bava U, Watson M, Lin JM, Tong PC, Chen Q, Chan VA, Reid HE, Fazzalari N, Baker HM, Baker EN, Haggarty NW, Grey AB, Reid IR (2004) Lactoferrin is a potent regulator of bone cell activity and increases bone. Formation in vivo. Endocrinology 145(9):4366-4374. doi: 10.1210/en.2003-1307
31. Liu G, Men P, Kenner GH, Miller SC (2006) Age-associated iron accumulation in bone: implications for postmenopausal osteoporosis and a new target for prevention and treatment by chelation. Biometals: Int J Role Metal Ions Biol, Biochem, Med 19(3):245-251. doi: 10.1007/s10534-005-6666-2
32. Liu G, Men P, Kenner GH, Miller SC (2008) Therapeutic effects of an oral chelator targeting skeletal tissue damage in experimental postmenopausal osteoporosis in rats. Hemoglobin 32(1-2):181-190. doi: 10.1080/03630260701726707
33. Pattanapanyasat K, Webster HK, Tongtawe P, Kongcharoen P, Hider RC (1992) Effect of orally active hydroxypyridinone iron chelators on human lymphocyte function. Br J Haematol 82(1):13-19. doi: 10.1111/j.1365-2141.1992.tb04587.x
34. Reichard P, Ehrenberg A (1983) Ribonucleotide reductase-a radical enzyme. Science 221(4610):514-519
35. Qu ZH, Zhang XL, Tang TT, Dai KR (2008) Promotion of osteogenesis through beta-catenin signaling by desferrioxamine. Biochem Bioph Res Co 370(2):332-337. doi: 10.1016/j.bbrc.2008.03.092
36. Suarez IG, Martin JLF, Diaz MN, Andia JBC (2003) Effect of desferrioxamine and deteriprone on the 1,25(OH)(2)D-3-stimulated osteocalcin secretion in osteoblast-like cells. Nefrologia 23:27-31
37. Ishii KA, Fumoto T, Iwai K, Takeshita S, Ito M, Shimohata N, Aburatani H, Taketani S, Lelliott CJ, Vidal-Puig A, Ikeda K (2009) Coordination of PGC-1beta and iron uptake in mitochondrial biogenesis and osteoclast activation. Nat Med 15(3):259-266. doi: 10.1038/nm.1910