A preliminary investigation of the mechanisms underlying the effect of berberine in preventing high-fat diet-induced insulin resistance in rats

Journal of Physiology and Pharmacology

Volumn 63, Issue 5, 2012, Pages 505-513

  Gu, J J ^a   Gao, F Y ^a   Zhao, T Y ^a  

^a SICHUAN UNIVERSITY   (China)

Author keywords

Berberine; Diabetes; Hepatocytes; High fat diet; Insulin resistance; Pancreatic cells; Pancreatic cells

Indexed keywords

BERBERINE; FATTY ACID; GLUCOSE; INSULIN; INSULIN RECEPTOR SUBSTRATE 1; INSULIN RECEPTOR SUBSTRATE 2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CELL ISOLATION; CONTROLLED STUDY; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG EFFECT; DRUG MECHANISM; HOMEOSTASIS; IMMUNOHISTOCHEMISTRY; INSULIN RESISTANCE; INTRAABDOMINAL FAT; MALE; METABOLIC PARAMETERS; NONHUMAN; OBESITY; PANCREAS ISLET ALPHA CELL; PANCREAS ISLET BETA CELL; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION;

ANIMALS; BERBERINE; CELLS, CULTURED; DIET, HIGH-FAT; FATTY ACIDS, NONESTERIFIED; GLUCAGON; GLUCAGON-SECRETING CELLS; GLUCOSE TOLERANCE TEST; HEPATOCYTES; HYPOGLYCEMIC AGENTS; INSULIN; INSULIN RECEPTOR SUBSTRATE PROTEINS; INSULIN RESISTANCE; INSULIN-SECRETING CELLS; MALE; RATS; RATS, WISTAR; RECEPTOR, INSULIN; TRIGLYCERIDES;

EID: 84870608269     PISSN: 08675910     EISSN: 18991505     Source Type: Journal    
DOI: None     Document Type: Article

References (34)

1. Gupta D, Krueger CB, Lastra G. Over-nutrition, obesity and insulin resistance in the development of beta cell dysfunction. Curr Diabetes Rev 2012; 8: 76-83.
2. Cnop M, Hannaert JC, Hoorens A, Eizirik DL, Pipeleers DG. Inverse relationship between cytotoxicity of free fatty acids in pancreatic islet cells and cellular triglyceride accumulation. Diabetes 2001; 50: 1771-1777.
3. Harbeck MC, Louie DC, Howland J, Wolf BA, Rothenberg PL. Expression of insulin receptor mRNA and insulin receptor substrate 1 in pancreatic islet beta-cells. Diabetes 1996; 45: 711-717.
4. Kobayashi M, Ohnishi H, Okazawa H, et al. Expression of Src homology 2 domain-containing protein tyrosine phosphatase substrate-1 in pancreatic beta-cells and its role in promotion of insulin secretion and protection against diabetes. Endocrinology 2008; 149: 5662-5669.
5. Martinez SC, Cras-Meneur C, Bernal-Mizrachi E, Permutt MA. Glucose regulates Foxo1 through insulin receptor signaling in the pancreatic islet beta-cell. Diabetes 2006; 55: 1581-1591.
6. Arner P. Insulin resistance in type 2 diabetes: role of fatty acids. Diabetes Metab Res Rev 2002; 18(Suppl. 2): S5-S9.
7. Griffin ME, Marcucci MJ, Cline GW, et al. Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade. Diabetes 1999; 48: 1270-1274.
8. Gual P, Le Marchand-Brustel Y, Tanti JF. Positive and negative regulation of insulin signaling through IRS-1 phosphorylation. Biochimie 2005; 87: 99-109.
9. Han P, Zhang YY, Lu Y, He B, Zhang W, Xia F. Effects of different free fatty acids on insulin resistance in rats. Hepatobiliary Pancreat Dis Int 2008; 7: 91-96.
10. Haber EP, Procopio J, Carvalho CR, Carpinelli AR, Newsholme P, Curi R. New insights into fatty acid modulation of pancreatic beta-cell function. Int Rev Cytol 2006; 248: 1-41.
11. Li J, Liu X, Ran X, et al. Sterol regulatory element-binding protein-1c knockdown protected INS-1E cells from lipotoxicity. Diabetes Obes Metab 2010; 12: 35-46.
12. Piro S, Maniscalchi ET, Monello A, et al. Palmitate affects insulin receptor phosphorylation and intracellular insulin signal in a pancreatic alpha-cell line. Endocrinology 2010; 151: 4197-4206.
13. Xiao J, Gregersen S, Pedersen SB, Hermansen K. Differential impact of acute and chronic lipotoxicity on gene expression in INS-1 cells. Metabolism 2002; 51: 155-162.
14. Araujo EP, Amaral ME, Souza CT, et al. Blockade of IRS1 in isolated rat pancreatic islets improves glucose-induced insulin secretion. FEBS Lett 2002; 531: 437-442.
15. Del Prato S, Marchetti P. Beta-and alpha-cell dysfunction in type 2 diabetes. Horm Metab Res 2004; 36: 775-781.
16. Dunning BE, Gerich JE. The role of alpha-cell dysregulation in fasting and postprandial hyperglycemia in type 2 diabetes and therapeutic implications. Endocr Rev 2007; 28: 253-283.
17. Tahrani AA, Bailey CJ, Del Prato S, Barnett AH. Management of type 2 diabetes: new and future developments in treatment. Lancet 2011; 378: 182-197.
18. Zhang Y, Li X, Zou D, et al. Treatment of type 2 diabetes and dyslipidemia with the natural plant alkaloid berberine. J Clin Endocrinol Metab 2008; 93: 2559-2565.
19. Zhou J, Zhou S, Tang J, et al. Protective effect of berberine on beta cells in streptozotocin-and high-carbohydrate/high-fat diet-induced diabetic rats. Eur J Pharmacol 2009; 606: 262-268.
20. Kong WJ, Zhang H, Song DQ, et al. Berberine reduces insulin resistance through protein kinase C-dependent up-regulation of insulin receptor expression. Metabolism 2009; 58: 109-119.
21. Zhang H, Wei J, Xue R, et al. Berberine lowers blood glucose in type 2 diabetes mellitus patients through increasing insulin receptor expression. Metabolism 2010; 59: 285-292.
22. Zhang X, Zhao Y, Zhang M, et al. Structural changes of gut microbiota during berberine-mediated prevention of obesity and insulin resistance in high-fat diet-fed rats. PLoS One 2012; 7: e42529.
23. Gao N, Zhao TY, Li XJ. The protective effect of berberine on beta-cell lipoapoptosis. J Endocrinol Invest 2011; 34: 124-130.
24. Wang Y, Campbell T, Perry B, Beaurepaire C, Qin L. Hypoglycemic and insulin-sensitizing effects of berberine in high-fat diet-and streptozotocin-induced diabetic rats. Metabolism 2011; 60: 298-305.
25. Tang LQ, Wei W, Chen LM, Liu S. Effects of berberine on diabetes induced by alloxan and a high-fat/high-cholesterol diet in rats. J Ethnopharmacol 2006; 108: 109-115.
26. Woods SC, Seeley RJ, Rushing PA, D'Alessio D, Tso P. A controlled high-fat diet induces an obese syndrome in rats. J Nutr 2003; 133: 1081-1087.
27. Storlien LH, Higgins JA, Thomas TC, et al. Diet composition and insulin action in animal models. Br J Nutr 2000; 83(Suppl 1): S85-S90.
28. Storlien LH, James DE, Burleigh KM, Chisholm DJ, Kraegen EW. Fat feeding causes widespread in vivo insulin resistance, decreased energy expenditure, and obesity in rats. Am J Physiol 1986; 251: E576-E583.
29. Gil K, Bugajski A, Thor P. Electrical vagus nerve stimulation decreases food consumption and weight gain in rats fed a high-fat diet. J Physiol Pharmacol 2011; 62: 637-646.
30. Duvnjak M, Tomasic V, Gomercic M, Smircic Duvnjak L, Barsic N, Lerotic I. Therapy of nonalcoholic fatty liver disease: current status. J Physiol Pharmacol 2009; 60(Suppl. 7): 57-66.
31. Leibiger IB, Brismar K, Berggren PO. Novel aspects on pancreatic beta-cell signal-transduction. Biochem Biophys Res Commun 2010; 396: 111-115.
32. Wang Q, Jin T. The role of insulin signaling in the development of beta-cell dysfunction and diabetes. Islets 2009; 1: 95-101.
33. Szczepanska-Sadowska E, Cudnoch-Jedrzejewska A, Ufnal M, Zera T. Brain and cardiovascular diseases: common neurogenic background of cardiovascular, metabolic and inflammatory diseases. J Physiol Pharmacol 2010; 61: 509-521.
34. Chen S, Li H, Liu Q. Effects of high-fat diet on insulin receptor substrate1 and 2 expressions in rats with fatty liver. Chin J Diabetes 2008; 16: 409-412.