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Volumn 18, Issue 50, 2012, Pages 16123-16128

Isolation and structural elucidation of armeniaspirols A-C: Potent antibiotics against gram-positive pathogens

(14) Dufour, Cosima a Wink, Joachim a Kurz, Michael a Kogler, Herbert a Olivan, Helene b Sablé, Serge b Heyse, Winfried a Gerlitz, Martin a Toti, Luigi a Nußer, Antje a Rey, Astrid b Couturier, Cedric b Bauer, Armin a Brönstrup, Mark a

a Parallel Synthesis and Natural Product Chemistry (Germany)

b SANOFI (France)

Author keywords

antibiotics; biosynthesis; drug discovery; natural products; spiro compounds; structure elucidation

Indexed keywords

CHEMICAL DEGRADATION; COMPUTER ASSISTED; DRUG DISCOVERY; GRAM-POSITIVE PATHOGENS; IN-VITRO; IN-VIVO; ISOLATED COMPOUNDS; LEAD STRUCTURE; NATURAL PRODUCTS; S. AUREUS; SPIRO COMPOUNDS; STRUCTURAL ELUCIDATION; STRUCTURE ELUCIDATION; STRUCTURE PREDICTION; VANCOMYCIN;

ALGORITHMS; AMINO ACIDS; BIOCHEMISTRY; BIOSYNTHESIS; CHEMICAL COMPOUNDS; EXPERIMENTS; MECHANISMS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; SCAFFOLDS; VOLATILE FATTY ACIDS; X RAY CRYSTALLOGRAPHY;

ANTIBIOTICS;

ANTIINFECTIVE AGENT; ARMENIASPIROL A; ARMENIASPIROL B; ARMENIASPIROL C; BIOLOGICAL PRODUCT; PYRROLE DERIVATIVE; SPIRO COMPOUND;

ARTICLE; BACTERIAL CELL; CHEMISTRY; DRUG DEVELOPMENT; DRUG EFFECT; GRAM POSITIVE BACTERIUM; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS INFECTION; X RAY CRYSTALLOGRAPHY;

ANTI-BACTERIAL AGENTS; BACTERIAL STRUCTURES; BIOLOGICAL AGENTS; CRYSTALLOGRAPHY, X-RAY; DRUG DISCOVERY; GRAM-POSITIVE BACTERIA; PYRROLES; SPIRO COMPOUNDS; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCUS AUREUS;

EID: 84870577113 PISSN: 09476539 EISSN: 15213765 Source Type: Journal
DOI: 10.1002/chem.201201635 Document Type: Article

Times cited : (48)

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