Novel streptopyrroles from Streptomyces rimosus with bacterial protein histidine kinase inhibitory and antimicrobial activities

Journal of Antibiotics

Volumn 53, Issue 1, 2000, Pages 1-11

  Trew, Sally J ^a   Wrigley, Stephen K ^a   Pairet, Lydie ^a   Sohal, Jess ^a   Shanu Wilson, Patrick ^a   Hayes, Martin A ^f   Martin, Steven M ^a   Manohar, Ravi N ^a   Chicarelli Robinson, M Inês ^g   Kau, David A ^a   Byrne, Colin V ^b   Wellington, Elizabeth M H ^d   Moloney, Janet M ^e   Howard, Judith ^e   Hupe, Donald ^c   Olson, Eric R ^c  

^a TerraGen Discovery UK Ltd   (United Kingdom)

^b Cantab Pharmaceuticals Ltd   (United Kingdom)

^c PFIZER INC   (United States)

^d UNIVERSITY OF WARWICK   (United Kingdom)

^e DURHAM UNIVERSITY   (United Kingdom)

^f GLAXOSMITHKLINE   (United Kingdom)

^g Molecular Nature Ltd   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BENZOXAZINE DERIVATIVE; PROTEIN HISTIDINE KINASE; PYRROLE DERIVATIVE; STREPTOPYRROLE; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ANTIBIOTIC BIOSYNTHESIS; ANTIFUNGAL ACTIVITY; ANTIMICROBIAL ACTIVITY; ARTICLE; CANCER CELL CULTURE; CARBON NUCLEAR MAGNETIC RESONANCE; DRUG CYTOTOXICITY; DRUG POTENCY; DRUG STRUCTURE; ENZYME INHIBITION; FERMENTATION; HUMAN; HUMAN CELL; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; SPECTROSCOPY; TAXONOMY; X RAY CRYSTALLOGRAPHY;

ESCHERICHIA COLI; STREPTOMYCES RIMOSUS;

EID: 17144433336     PISSN: 00218820     EISSN: None     Source Type: Journal    
DOI: 10.7164/antibiotics.53.1     Document Type: Article

References (16)

1. STOCK, J. B.; A. M. STOCK & J. M. MOTTONEN: Signal transduction in bacteria. Nature 344: 395-400, 1990
2. ALEX, L. A. & M. I. SIMON: Protein histidine kinases and signal transduction in prokaryotes and eukaryotes. Trends In Genetics 10: 133-138, 1994
3. MAEDA, T.; S. M. WURGLER-MURPHY & H. SAITO: A two-component system that regulates an osmosensing MAP kinase cascade in yeast. Nature 369: 242-245, 1994
4. ALEX, L. A.; K. A. BOROKOVICH & M. I . SIMON: Hyphal development in Neurospora crassa: Involvement of a two-component histidine kinase. Proc. Natl. Acad. Sci. USA 93: 3416-3421, 1996
5. HUGHES, D. A.: Histidine kinases hog the limelight. Nature 369: 187-188, 1994
6. CHANG, C.; S. F. KWOK, A. B. BLEEKER & E. M. MEYEROWITZ: Arabidopsis ethylene-response gene ETR1: Similarity of product to two-component regulators. Science 262: 539-544, 1993
7. BARRETT, J. F.; R. M. GOLDSCHMIDT, L. E. LAWRENCE, B. FOLENO, R. CHEN, J. P. DEMERS, S. JOHNSON, R. KANOJIA, J. FERNANDEZ, J. BERNSTEIN, L. LICATA, A. DONETZ, S. HUANG, D. J. HLASTA, M. J. MACIELAG, K. OHEMENG, R. FRECHETTE, M. B. FROSCO, D. H. KLAUBERT, J. M. WHITELEY, L. WANG & J. A. HOCH: Antibacterial agents that inhibit two-component signal transduction systems. Proc. Natl. Acad. Sci. USA 95: 5317-5322, 1998
8. BREINHOLT, J.; H. GÜRTLER, A. KJAR, S. E. NIELSEN, C. E. OLSEN: Streptopyrrole: an antimicrobial metabolite from Streptomyces armeniacus. Acta Chem. Scand. 52: 1040-1044, 1998
9. WILLIAMS S. T.; M. GOODFELLOW, E. M. H. WELLINGTON, J. C. VICKERS, G. ALDERSON, P. H. A. SNEATH, M. J. SACKIN & A. M. MORTIMER: A probability matrix for identification of streptomycetes. J. Gen. Microbiol. 129: 1815-130, 1983
10. KAMBEROV, E. S.; M. R. ATKINSON, P. CHANDRAN & A. J. NINFA: Effect of mutations in Escherichia coli glnL (ntrB), encoding nitrogen regulator II (NRII or NtrB), on the phosphatase activity involved in bacterial nitrogen regulation. J. Biol. Chem. 269: 28294-28299, 1994
11. KAWAMURA, N. & R. SAWA, Y, TAKAHASHI, K. ISSIKI, T. SAWA, N. KINOSHITA, H. NAGANAWA, M. HAMADA, T. TAKEUCHI: Pyralomicins, new antibiotics from Actinomadura spiralis. J. Antibiotics 48(5): 435-437, 1995
12. British Standards Institution: British Standard Specification for Colours for Identification, Coding and Special Purposes. BS381C, 1988
13. STANECK, J. L. & G. D. ROBERTS: Simplified approach to identification of aerobic actinomycetes by thin layer chromatography. Appl. Microbiol. 28: 226-231, 1974
14. COSIER, J. & A. M. GLAZER: A nitrogen-gas-stream cryostat for general x-ray diffraction studies. J. Appl. Cryst. 19: 105-107, 1986
15. SIEMENS: SAINT. Data Reduction Software. Version 4.05. Siemens Analytical X-Ray Instruments Inc., Madison, Wisconsin, USA
16. SIEMENS: SHELXTL. Version 5.03/VMS. Siemens Analytical X-Ray Instruments Inc., Madison, Wisconsin, USA