Armeniaspiroles, a new class of antibacterials: Antibacterial activities and total synthesis of 5-chloro-Armeniaspirole A

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 19, 2012, Pages 6292-6296

  Couturier, Cédric ^a   Bauer, Armin ^b   Rey, Astrid ^a   Schroif Dufour, Cosima ^b   Broenstrup, Mark ^b  

^a SANOFI   (France)

^b Sanofi Deutschland GmbH   (Germany)

Author keywords

Antibacterials; Armeniaspirole; Gram positive bacterial pathogens; Natural products; Total synthesis

Indexed keywords

5 CHLORO ARMENIASPIROLE A; ANTIINFECTIVE AGENT; UNCLASSIFIED DRUG;

ALKYLATION; ANTIBACTERIAL ACTIVITY; ARTICLE; CHLORINATION; CONCENTRATION (PARAMETERS); CYCLIZATION; DOSE RESPONSE; DRUG HALF LIFE; DRUG SOLUBILITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENTEROCOCCUS FAECIUM; FRIEDEL CRAFTS REACTION; HALOGENATION; IC 50; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; NONHUMAN; STREPTOCOCCUS PNEUMONIAE; STREPTOMYCES; STREPTOMYCES ARMENIACUS; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTI-BACTERIAL AGENTS; BIOLOGICAL AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG RESISTANCE, MULTIPLE, BACTERIAL; ENTEROCOCCUS FAECIUM; ETHER-A-GO-GO POTASSIUM CHANNELS; HUMANS; LACTAMS; MALE; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS; MICE; MOLECULAR STRUCTURE; SPIRO COMPOUNDS; STREPTOCOCCUS PNEUMONIAE; STRUCTURE-ACTIVITY RELATIONSHIP;

BACTERIA (MICROORGANISMS); POSIBACTERIA; STREPTOMYCES ARMENIACUS;

EID: 84866391845     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.06.107     Document Type: Article

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