Treatment of traumatic brain injury using zinc-finger protein gene therapy targeting VEGF-A

Journal of Neurotrauma

Volumn 29, Issue 17, 2012, Pages 2647-2659

  Siddiq, Ishita ^a,b   Park, Eugene ^b   Liu, Elaine ^b   Spratt, S Kaye ^c   Surosky, Richard ^c   Lee, Gary ^c   Ando, Dale ^c   Giedlin, Marty ^c   Hare, Gregory M T ^a,b,e   Fehlings, Michael G ^a,d   Baker, Andrew J ^a,b,e  

^a UNIVERSITY OF TORONTO   (Canada)

^b ST MICHAEL'S HOSPITAL   (Canada)

^c SANGAMO BIOSCIENCES INC   (United States)

^d UNIVERSITY OF TORONTO   (Canada)

^e ST MICHAEL'S HOSPITAL   (Canada)

Author keywords

Adeno associated virus; adenovirus; electrophysiology; gene therapy; microvasculature; traumatic brain injury

Indexed keywords

NEUROPROTECTIVE AGENT; UNCLASSIFIED DRUG; VASCULOTROPIN A; ZINC FINGER PROTEIN ACTIVATOR;

ADENO ASSOCIATED VIRUS; ADENOVIRUS; ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; DRUG TARGETING; DRUG TRANSPORT; MALE; NEUROPROTECTION; NONHUMAN; RAT; ROTAROD TEST; THERAPY DELAY; TRAUMATIC BRAIN INJURY; VIRAL GENE DELIVERY SYSTEM;

ANIMALS; BLOTTING, WESTERN; BRAIN INJURIES; CA1 REGION, HIPPOCAMPAL; CAPILLARIES; DEPENDOVIRUS; EXCITATORY POSTSYNAPTIC POTENTIALS; GENETIC THERAPY; GENETIC VECTORS; IN SITU NICK-END LABELING; LONG-TERM POTENTIATION; MALE; MICROINJECTIONS; NEOVASCULARIZATION, PHYSIOLOGIC; RATS; RATS, SPRAGUE-DAWLEY; RECOVERY OF FUNCTION; VASCULAR ENDOTHELIAL GROWTH FACTOR A; ZINC FINGERS;

EID: 84870512593     PISSN: 08977151     EISSN: 15579042     Source Type: Journal    
DOI: 10.1089/neu.2012.2444     Document Type: Article

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