Modulation of vascular endothelial growth factor (VEGF) expression in motor neurons and its electrophysiological effects

Brain Research Bulletin

Volumn 76, Issue 1-2, 2008, Pages 36-44

  McCloskey, Daniel P ^a,b   Hintz, Tana M ^b   Scharfman, Helen E ^b,c  

^a CITY UNIVERSITY OF NEW YORK   (United States)

^b HELEN HAYES HOSPITAL   (United States)

^c NATHAN S KLINE INSTITUTE FOR PSYCHIATRIC RESEARCH   (United States)

Author keywords

Amyotrophic lateral sclerosis (ALS); Facial nucleus; Hypoglossal nucleus; Seizures; Spinal cord; Status

Indexed keywords

VASCULOTROPIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN SLICE; BRAIN STEM; CONTROLLED STUDY; ELECTROPHYSIOLOGY; IMMUNOCYTOCHEMISTRY; MALE; MOTONEURON; NEUROCHEMISTRY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SEIZURE;

ANIMALS; BRAIN STEM; ELECTROPHYSIOLOGY; HUMANS; MALE; MOTOR NEURONS; RATS; RATS, SPRAGUE-DAWLEY; SEIZURES; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 41449102443     PISSN: 03619230     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainresbull.2007.11.018     Document Type: Article

References (31)

1. Anderson K., Fugaccia I., and Scheff S. Fluoro-jade B stains quiescent and reactive astrocytes in the rodent spinal cord. J. Neurotrauma. 20 (2003) 1223-1231
2. Azzouz M., Ralph G.S., Storkebaum E., Walmsley L.E., Mitrophanous K.A., Kingsman S.M., Carmeliet P., and Mazarakis N.D. VEGF delivery with retrogradely transported lentivector prolongs survival in a mouse ALS model. Nature 429 (2004) 413-417
3. Bartholdi D., Rubin B., and Schwab M. VEGF mRNA induction correlates with changes in the vascular architecture upon spinal cord damage in the rat. Eur. J. Neurosci. 9 (1997) 2549-2560
4. Binder D.K., and Scharfman H.E. Growth Factors and Epilepsy (2005), Nova Sciences, New York
5. Choi K.S., Bae M.K., Jeong J.W., Moon H.E., and Kim K.W. Hypoxia-induced angiogenesis during carcinogenesis. J. Biochem. Mol. Biol. 36 (2003) 120-127
6. Devos D., Moreau C., Lassalle P., Perez T., De Seze J., Brunaud-Danel V., Destee A., Tonnel A.B., and Just N. Low levels of the vascular endothelial growth factor in CSF from early ALS patients. Neurology 62 (2004) 2127-2129
7. Heath P.R., and Shaw P.J. Update on the glutamatergic neurotransmitter system and the role of excitotoxicity in amyotrophic lateral sclerosis. Muscle Nerve 26 (2002) 438-458
8. Lambrechts D., Storkebaum E., and Carmeliet P. VEGF: necessary to prevent motoneuron degeneration, sufficient to treat ALS?. Trends Mol. Med. 10 (2004) 275-282
9. Lambrechts D., Storkebaum E., Morimoto M., Del-Favero J., Desmet F., Marklund S.L., Wyns S., Thijs V., Andersson J., Van Marion I., Al-Chalabi A., Bornes S., Musson R., Hansen V., Beckman L., Adolfsson R., Pall H.S., Prats H., Vermeire S., Rutgeerts P., Katayama S., Awata T., Leigh N., Lang-Lazdunski L., Dewerchin M., Shaw C., Moons L., Vlietinck R., Morrison K.E., Robberecht W., Van Broeckhoven C., Collen D., Andersen P.M., and Carmeliet P. VEGF is a modifier of amyotrophic lateral sclerosis in mice and humans and protects motoneurons against ischemic death. Nat. Genet. 34 (2003) 383-394
10. McCloskey D.P., Croll S.D., and Scharfman H.E. Depression of synaptic transmission by vascular endothelial growth factor in adult rat hippocampus and evidence for increased efficacy after chronic seizures. J. Neurosci. 25 (2005) 8889-8897
11. Newton S.S., Collier E.F., Hunsberger J., Adams D., Terwilliger R., Selvanayagam E., and Duman R.S. Gene profile of electroconvulsive seizures: induction of neurotrophic and angiogenic factors. J. Neurosci. 23 (2003) 10841-10851
12. J. Nicoletti, S. Sachin, D.P. McCloskey, J.H. Goodman, H.E. Scharfman, S.D. Croll, in press. Vascular endothelial growth factor (VEGF) is upregulated after status epilepticus and protects against seizure-induced neuronal loss in hippocampus, Neuroscience.
13. Olsson A.K., Dimberg A., Kreuger J., and Claesson-Welsh L. VEGF receptor signalling-in control of vascular function. Nat. Rev. Mol. Cell Biol. 7 (2006) 359-371
14. Oosthuyse B., Moons L., Storkebaum E., Beck H., Nuyens D., Brusselmans K., Van Dorpe J., Hellings P., Gorselink M., Heymans S., Theilmeier G., Dewerchin M., Laudenbach V., Vermylen P., Raat H., Acker T., Vleminckx V., Van Den Bosch L., Cashman N., Fujisawa H., Drost M., Sciot R., Bruyninckx F., Hicklin D., Ince C., Gressens P., Lupu F., Plate K., Robberecht W., Herbert J., Collen D., and Carmeliet P. Deletion of the hypoxia-response element in the vascular endothelial growth factor promoter causes motor neuron degeneration. Nat. Genet. 28 (2001) 107-108
15. Pitkanen A., Schwartzkroin P.A., and Moshe S.L. Models of Seizures and Epilepsy (2005), Elsevier, New York
16. Racine R.J. Modification of seizure activity by electrical stimulation. II. Motor seizure. Electroencephal. Clin. Neurophys. 32 (1972) 281-294
17. Scarisbrick I.A., Isackson P.J., and Windebank A.J. Differential expression of brain-derived neurotrophic factor, neurotrophin-3, and neurotrophin-4/5 in the adult rat spinal cord: regulation by the glutamate receptor agonist kainic acid. J. Neurosci. 19 (1999) 7757-7769
18. Scharfman H.E. Electrophysiological diversity of pyramidal shaped neurons at the granule cell layer hilus border of the rat dentate gyrus recorded in vitro. Hippocampus 5 (1995) 287-305
19. Scharfman H.E. Epilepsy as an example of neural plasticity. The Neuroscientist 8 (2002) 154-173
20. Scharfman H.E. Seizure-induced neurogenesis in the dentate gyrus and its dependence on growth factors and cytokines. In: Binder D.K., and Scharfman H.E. (Eds). Growth Factors and Epilepsy (2006), Nova Science Publishers, New York 1-40
21. Scharfman H.E., Sollas A.L., Smith K.L., Jackson M.B., and Goodman J.H. Structural and functional asymmetry in the normal and epileptic rat dentate gyrus. J. Comp. Neurol. 454 (2002) 424-439
22. Sloviter R.S. A simplified Timm stain procedure compatible with formaldehyde fixation and routine paraffin embedding of rat brain. Brain Res. Bull. 8 (1982) 771-774
23. Sopher B.L., Thomas P.S., LaFevre-Bernt M.A., Holm I.E., Wilke S.A., Ware C.B., Jin L.W., Libby R.T., Ellerby L.M., and La Spada A.R. Androgen receptor YAC transgenic mice recapitulate SBMA motor neuronopathy and implicate VEGF164 in the motor neuron degeneration. Neuron 41 (2004) 687-699
24. Storkebaum E., Lambrechts D., Dewerchin M., Moreno-Murciano M.-P., Appelmans S., Oh H., Van Damme P., Rutten B., Man W.Y., De Mol M., Wyns S., Manka D., Vermeulen K., Van Den Bosch L., Mertens N., Schmitz C., Robberecht W., Conway E.M., Collen D., Moons L., and Carmeliet P. Treatment of motoneuron degeneration by intracerebroventricular delivery of VEGF in a rat model of ALS. Nat. Neurosci. 8 (2005) 85-92
25. Sun Y., JIn K., Xie L., Childs J., Mao X.O., Logvinova A., and Greenberg D.A. VEGF-induced neuroprotection, neurogenesis, and angiogenesis after focal cerebral ischemia. J. Clin. Invest. 111 (2003) 1843-1851
26. Takahashi H., and Shibuya M. The vascular endothelial growth factor (VEGF)/VEGF receptor system and its role under physiological and pathological conditions. Clin. Sci. (Lond) 109 (2005) 227-241
27. Turski L., Ikonomidou C., Turski W.A., Bortolotto Z.A., and Cavalheiro E.A. Review: cholinergic mechanisms and epileptogenesis. The seizures induced by pilocarpine: a novel experimental model of intractable epilepsy. Synapse 3 (1989) 154-171
28. Turski W.A., Cavalheiro E.A., Schwarz M., Czuczsar S.J., Kleinrok Z., and Turski L. Limbic seizures produced by pilocarpine in rats: behavioural, electroencephalographic and neuropathological study. Behav. Brain Res. 9 (1983) 315-335
29. Croll S., Goodman J., and Scharfman H. Vascular endothelial growth factor (VEGF) in seizures: a double-edged sword. Adv. Exp. Med. Biol. 548 (2004) 57-68
30. Van Damme P., Dewil M., Robberecht W., and Van Den Bosch L. Excitotoxicity and amyotrophic lateral sclerosis. Neurodegen. Dis. 2 (2005) 147-159
31. Wang Y., Jin K., Mao X.O., Xie L., Banwait S., Marti H.H., and Greenberg D.A. Vascular endothelial growth factor overexpression delays neurodegeneration and prolongs survival in amyotrophic lateral sclerosis mice. J. Neurosci. 27 (2007) 304-307