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Volumn 23, Issue 1, 2006, Pages 21-34

Inhibition of vascular endothelial growth factor receptor 2 activity in experimental brain contusions aggravates injury outcome and leads to early increased neuronal and glial degeneration

Author keywords

Glial fibrillary acidic protein; Microtubuli associated protein 2; Neuron specific enolase; Rat; S100

Indexed keywords

CELL ADHESION MOLECULE; GLIAL FIBRILLARY ACIDIC PROTEIN; MICROTUBULE ASSOCIATED PROTEIN 2; NEURON SPECIFIC ENOLASE; PROTEIN S100B; VASCULOTROPIN; VASCULOTROPIN RECEPTOR; VASCULOTROPIN RECEPTOR 2; VON WILLEBRAND FACTOR;

EID: 33644949372     PISSN: 0953816X     EISSN: 14609568     Source Type: Journal    
DOI: 10.1111/j.1460-9568.2005.04527.x     Document Type: Article
Times cited : (60)

References (97)
  • 1
    • 0033496252 scopus 로고    scopus 로고
    • Activated microvessels express vascular endothelial growth factor and integrin alpha(v)beta3 during focal cerebral ischemia
    • Abumiya T. Lucero J. Heo JH. Tagaya M. Koziol JA. Copeland BR. del Zoppo GJ. 1999 Activated microvessels express vascular endothelial growth factor and integrin alpha(v)beta3 during focal cerebral ischemia JCerebBlood Flow Metab 19 1038 1050
    • (1999) JCerebBlood Flow Metab , vol.19 , pp. 1038-1050
    • Abumiya, T.1    Lucero, J.2    Heo, J.H.3    Tagaya, M.4    Koziol, J.A.5    Copeland, B.R.6    Del Zoppo, G.J.7
  • 2
    • 0034999195 scopus 로고    scopus 로고
    • Increase in serum S100A1-B and S100BB during cardiac surgery arises from extracerebral sources
    • Anderson RE. Hansson LO. Nilsson O. Liska J. Settergren G. Vaage J. 2001 Increase in serum S100A1-B and S100BB during cardiac surgery arises from extracerebral sources AnnThorac Surg 71 1512 1517
    • (2001) AnnThorac Surg , vol.71 , pp. 1512-1517
    • Anderson, R.E.1    Hansson, L.O.2    Nilsson, O.3    Liska, J.4    Settergren, G.5    Vaage, J.6
  • 4
    • 0031419189 scopus 로고    scopus 로고
    • VEGF mRNA induction correlates with changes in the vascular architecture upon spinal cord damage in the rat
    • Bartholdi D. Rubin BP. Schwab ME. 1997 VEGF mRNA induction correlates with changes in the vascular architecture upon spinal cord damage in the rat EurJNeurosci 9 2549 2560
    • (1997) EurJNeurosci , vol.9 , pp. 2549-2560
    • Bartholdi, D.1    Rubin, B.P.2    Schwab, M.E.3
  • 7
    • 0026593331 scopus 로고
    • Expression of vascular endothelial growth factor during embryonic angiogenesis and endothelial cell differentiation
    • Breier G. Albrecht U. Sterrer S. Risau W. 1992 Expression of vascular endothelial growth factor during embryonic angiogenesis and endothelial cell differentiation Development 114 521 532
    • (1992) Development , vol.114 , pp. 521-532
    • Breier, G.1    Albrecht, U.2    Sterrer, S.3    Risau, W.4
  • 9
    • 0037699955 scopus 로고    scopus 로고
    • Angiogenesis in health and disease
    • Carmeliet P. 2003 Angiogenesis in health and disease NatMed 9 653 660
    • (2003) NatMed , vol.9 , pp. 653-660
    • Carmeliet, P.1
  • 11
    • 0025933332 scopus 로고
    • Angioblast differentiation and morphogenesis of the vascular endothelium in the mouse embryo
    • Coffin JD. Harrison J. Schwartz S. Heimark R. 1991 Angioblast differentiation and morphogenesis of the vascular endothelium in the mouse embryo DevBiol 148 51 62
    • (1991) DevBiol , vol.148 , pp. 51-62
    • Coffin, J.D.1    Harrison, J.2    Schwartz, S.3    Heimark, R.4
  • 14
    • 0019421846 scopus 로고
    • Response to cortical injury. I. Methodology and local effects of contusions in the rat
    • Feeney DM. Boyeson MG. Linn RT. Murray HM. Dail WG. 1981 Response to cortical injury. I. Methodology and local effects of contusions in the rat Brain Res 211 67 77
    • (1981) Brain Res , vol.211 , pp. 67-77
    • Feeney, D.M.1    Boyeson, M.G.2    Linn, R.T.3    Murray, H.M.4    Dail, W.G.5
  • 16
    • 0037699954 scopus 로고    scopus 로고
    • The biology of VEGF and its receptors
    • Ferrara N. Gerber HP. LeCouter J. 2003 The biology of VEGF and its receptors NatMed 9 669 676
    • (2003) NatMed , vol.9 , pp. 669-676
    • Ferrara, N.1    Gerber, H.P.2    Lecouter, J.3
  • 17
    • 0036354737 scopus 로고    scopus 로고
    • Hypoxia-induced hyperpermeability in brain microvessel endothelial cells involves VEGF-mediated changes in the expression of zonula occludens-1
    • Fischer S. Wobben M. Marti HH. Renz D. Schaper W. 2002 Hypoxia-induced hyperpermeability in brain microvessel endothelial cells involves VEGF-mediated changes in the expression of zonula occludens-1 MicrovascRes 63 70 80
    • (2002) MicrovascRes , vol.63 , pp. 70-80
    • Fischer, S.1    Wobben, M.2    Marti, H.H.3    Renz, D.4    Schaper, W.5
  • 18
    • 0032893263 scopus 로고    scopus 로고
    • SU5416 is a potent and selective inhibitor of the vascular endothelial growth factor receptor (Flk-1/KDR) that inhibits tyrosine kinase catalysis, tumor vascularization, and growth of multiple tumor types
    • Fong TA. Shawver LK. Sun L. Tang C. App H. Powell TJ. Kim YH. Schreck R. Wang X. Risau W. Ullrich A. Hirth KP. McMahon G. 1999 SU5416 is a potent and selective inhibitor of the vascular endothelial growth factor receptor (Flk-1/KDR) that inhibits tyrosine kinase catalysis, tumor vascularization, and growth of multiple tumor types Cancer Res 59 99 106
    • (1999) Cancer Res , vol.59 , pp. 99-106
    • Fong, T.A.1    Shawver, L.K.2    Sun, L.3    Tang, C.4    App, H.5    Powell, T.J.6    Kim, Y.H.7    Schreck, R.8    Wang, X.9    Risau, W.10    Ullrich, A.11    Hirth, K.P.12    McMahon, G.13
  • 19
    • 0034821652 scopus 로고    scopus 로고
    • Wound-induced angiogenesis and its pharmacologic inhibition in a murine model
    • Gelaw B. Levin S. 2001 Wound-induced angiogenesis and its pharmacologic inhibition in a murine model Surgery 130 497 501
    • (2001) Surgery , vol.130 , pp. 497-501
    • Gelaw, B.1    Levin, S.2
  • 21
    • 0021844825 scopus 로고
    • Human von Willebrand factor (vWF): Isolation of complementary DNA (cDNA) clones and chromosomal localization
    • Ginsburg D. Handin RI. Bonthron DT. Donlon TA. Bruns GA. Latt SA. Orkin SH. 1985 Human von Willebrand factor (vWF): isolation of complementary DNA (cDNA) clones and chromosomal localization Science 228 1401 1406
    • (1985) Science , vol.228 , pp. 1401-1406
    • Ginsburg, D.1    Handin, R.I.2    Bonthron, D.T.3    Donlon, T.A.4    Bruns, G.A.5    Latt, S.A.6    Orkin, S.H.7
  • 23
    • 0043062771 scopus 로고    scopus 로고
    • Significance of serum neuron-specific enolase in patients with acute traumatic brain injury
    • Guan W. Yang YL. Xia WM. Li L. Gong DS. 2003 Significance of serum neuron-specific enolase in patients with acute traumatic brain injury ChinJTraumatol 6 218 221
    • (2003) ChinJTraumatol , vol.6 , pp. 218-221
    • Guan, W.1    Yang, Y.L.2    Xia, W.M.3    Li, L.4    Gong, D.S.5
  • 25
    • 22944483792 scopus 로고    scopus 로고
    • The blood-brain barrier/neurovascular unit in health and disease
    • Hawkins BT. Davis TP. 2005 The blood-brain barrier/neurovascular unit in health and disease PharmacolRev 57 173 185
    • (2005) PharmacolRev , vol.57 , pp. 173-185
    • Hawkins, B.T.1    Davis, T.P.2
  • 26
    • 0031826273 scopus 로고    scopus 로고
    • Reduction of ischemic damage by application of vascular endothelial growth factor in rat brain after transient ischemia
    • Hayashi T. Abe K. Itoyama Y. 1998 Reduction of ischemic damage by application of vascular endothelial growth factor in rat brain after transient ischemia JCerebBlood Flow Metab 18 887 895
    • (1998) JCerebBlood Flow Metab , vol.18 , pp. 887-895
    • Hayashi, T.1    Abe, K.2    Itoyama, Y.3
  • 27
    • 0033653221 scopus 로고    scopus 로고
    • Vascular endothelial growth factor (VEGF) stimulates monocyte migration through endothelial monolayers via increased integrin expression
    • Heil M. Clauss M. Suzuki K. Buschmann IR. Willuweit A. Fischer S. Schaper W. 2000 Vascular endothelial growth factor (VEGF) stimulates monocyte migration through endothelial monolayers via increased integrin expression EurJCell Biol 79 850 857
    • (2000) EurJCell Biol , vol.79 , pp. 850-857
    • Heil, M.1    Clauss, M.2    Suzuki, K.3    Buschmann, I.R.4    Willuweit, A.5    Fischer, S.6    Schaper, W.7
  • 28
    • 0032915581 scopus 로고    scopus 로고
    • Protein S-100B and neuron specific enolase as early neurobiochemical markers of the severity of traumatic brain injury
    • Herrmann M. Curio N. Jost S. Wunderlich MT. Synowitz H. Wallesch CW. 1999 Protein S-100B and neuron specific enolase as early neurobiochemical markers of the severity of traumatic brain injury RestorNeurolNeurosci 14 109 114
    • (1999) RestorNeurolNeurosci , vol.14 , pp. 109-114
    • Herrmann, M.1    Curio, N.2    Jost, S.3    Wunderlich, M.T.4    Synowitz, H.5    Wallesch, C.W.6
  • 29
    • 0033995420 scopus 로고    scopus 로고
    • Temporal profile of release of neurobiochemical markers of brain damage after traumatic brain injury is associated with intracranial pathology as demonstrated in cranial computerized tomography
    • Herrmann M. Jost S. Kutz S. Ebert AD. Kratz T. Wunderlich MT. Synowitz H. 2000 Temporal profile of release of neurobiochemical markers of brain damage after traumatic brain injury is associated with intracranial pathology as demonstrated in cranial computerized tomography JNeurotrauma 17 113 122
    • (2000) JNeurotrauma , vol.17 , pp. 113-122
    • Herrmann, M.1    Jost, S.2    Kutz, S.3    Ebert, A.D.4    Kratz, T.5    Wunderlich, M.T.6    Synowitz, H.7
  • 30
    • 0035139075 scopus 로고    scopus 로고
    • Release of biochemical markers of damage to neuronal and glial brain tissue is associated with short and long term neuropsychological outcome after traumatic brain injury
    • Herrmann M. Curio N. Jost S. Grubich C. Ebert AD. Fork ML. Synowitz H. 2001 Release of biochemical markers of damage to neuronal and glial brain tissue is associated with short and long term neuropsychological outcome after traumatic brain injury JNeurolNeurosurgPsychiat 70 95 100
    • (2001) JNeurolNeurosurgPsychiat , vol.70 , pp. 95-100
    • Herrmann, M.1    Curio, N.2    Jost, S.3    Grubich, C.4    Ebert, A.D.5    Fork, M.L.6    Synowitz, H.7
  • 32
    • 0033597564 scopus 로고    scopus 로고
    • Long-term intracerebral inflammatory response after experimental focal brain injury in rat
    • Holmin S. Mathiesen T. 1999 Long-term intracerebral inflammatory response after experimental focal brain injury in rat Neuroreport 10 1889 1891
    • (1999) Neuroreport , vol.10 , pp. 1889-1891
    • Holmin, S.1    Mathiesen, T.2
  • 33
  • 34
    • 0344074656 scopus 로고    scopus 로고
    • Intracerebral inflammation after human brain contusion
    • ; discussion 298 299
    • Holmin S. Soderlund J. Biberfeld P. Mathiesen T. 1998 Intracerebral inflammation after human brain contusion Neurosurgery 42 291 298 ; discussion 298 299
    • (1998) Neurosurgery , vol.42 , pp. 291-298
    • Holmin, S.1    Soderlund, J.2    Biberfeld, P.3    Mathiesen, T.4
  • 35
  • 36
    • 0142195713 scopus 로고    scopus 로고
    • Biochemical serum markers for brain damage: A short review with emphasis on clinical utility in mild head injury
    • Ingebrigtsen T. Romner B. 2003 Biochemical serum markers for brain damage: a short review with emphasis on clinical utility in mild head injury RestorNeurolNeurosci 21 171 176
    • (2003) RestorNeurolNeurosci , vol.21 , pp. 171-176
    • Ingebrigtsen, T.1    Romner, B.2
  • 37
    • 0000481740 scopus 로고    scopus 로고
    • Vascular endothelial growth factor: Direct neuroprotective effect in in vitro ischemia
    • 242-10 247
    • Jin KL. Mao XO. Greenberg DA. 2000a Vascular endothelial growth factor: direct neuroprotective effect in in vitro ischemia ProcNatl AcadSciUSA 97 10 242 10 247
    • (2000) ProcNatl AcadSciUSA , vol.97 , pp. 10
    • Jin, K.L.1    Mao, X.O.2    Greenberg, D.A.3
  • 38
    • 0034638448 scopus 로고    scopus 로고
    • Induction of vascular endothelial growth factor receptors and phosphatidylinositol 3′-kinase/Akt signaling by global cerebral ischemia in the rat
    • Jin KL. Mao XO. Nagayama T. Goldsmith PC. Greenberg DA. 2000b Induction of vascular endothelial growth factor receptors and phosphatidylinositol 3′-kinase/Akt signaling by global cerebral ischemia in the rat Neuroscience 100 713 717
    • (2000) Neuroscience , vol.100 , pp. 713-717
    • Jin, K.L.1    Mao, X.O.2    Nagayama, T.3    Goldsmith, P.C.4    Greenberg, D.A.5
  • 39
    • 0035842544 scopus 로고    scopus 로고
    • Caspase-3 and the regulation of hypoxic neuronal death by vascular endothelial growth factor
    • Jin K. Mao XO. Batteur SP. McEachron E. Leahy A. Greenberg DA. 2001 Caspase-3 and the regulation of hypoxic neuronal death by vascular endothelial growth factor Neuroscience 108 351 358
    • (2001) Neuroscience , vol.108 , pp. 351-358
    • Jin, K.1    Mao, X.O.2    Batteur, S.P.3    McEachron, E.4    Leahy, A.5    Greenberg, D.A.6
  • 40
    • 0037015059 scopus 로고    scopus 로고
    • Vascular endothelial growth factor (VEGF) stimulates neurogenesis in vitro and in vivo
    • 946-11 950
    • Jin K. Zhu Y. Sun Y. Mao XO. Xie L. Greenberg DA. 2002 Vascular endothelial growth factor (VEGF) stimulates neurogenesis in vitro and in vivo ProcNatl AcadSciUSA 99 11 946 11 950
    • (2002) ProcNatl AcadSciUSA , vol.99 , pp. 11
    • Jin, K.1    Zhu, Y.2    Sun, Y.3    Mao, X.O.4    Xie, L.5    Greenberg, D.A.6
  • 43
    • 0742324441 scopus 로고    scopus 로고
    • Vascular endothelial growth factor promotes neurite maturation in primary CNS neuronal cultures
    • Khaibullina AA. Rosenstein JM. Krum JM. 2004 Vascular endothelial growth factor promotes neurite maturation in primary CNS neuronal cultures Brain ResDevBrain Res 148 59 68
    • (2004) Brain ResDevBrain Res , vol.148 , pp. 59-68
    • Khaibullina, A.A.1    Rosenstein, J.M.2    Krum, J.M.3
  • 44
    • 0034756366 scopus 로고    scopus 로고
    • Magnetic resonance imaging of ethyl-nitrosourea-induced rat gliomas: A model for experimental therapeutics of low-grade gliomas
    • Kish PE. Blaivas M. Strawderman M. Muraszko KM. Ross DA. Ross BD. McMahon G. 2001 Magnetic resonance imaging of ethyl-nitrosourea-induced rat gliomas: a model for experimental therapeutics of low-grade gliomas JNeurooncol 53 243 257
    • (2001) JNeurooncol , vol.53 , pp. 243-257
    • Kish, P.E.1    Blaivas, M.2    Strawderman, M.3    Muraszko, K.M.4    Ross, D.A.5    Ross, B.D.6    McMahon, G.7
  • 45
    • 0029745025 scopus 로고    scopus 로고
    • VEGF and flt. Expression time kinetics in rat brain infarct
    • ; discussion 1872 1863
    • Kovacs Z. Ikezaki K. Samoto K. Inamura T. Fukui M. 1996 VEGF and flt. Expression time kinetics in rat brain infarct Stroke 27 1865 1872 ; discussion 1872 1863
    • (1996) Stroke , vol.27 , pp. 1865-1872
    • Kovacs, Z.1    Ikezaki, K.2    Samoto, K.3    Inamura, T.4    Fukui, M.5
  • 46
    • 0032211352 scopus 로고    scopus 로고
    • VEGF mRNA and its receptor flt-1 are expressed in reactive astrocytes following neural grafting and tumor cell implantation in the adult CNS
    • Krum JM. Rosenstein JM. 1998 VEGF mRNA and its receptor flt-1 are expressed in reactive astrocytes following neural grafting and tumor cell implantation in the adult CNS ExpNeurol 154 57 65
    • (1998) ExpNeurol , vol.154 , pp. 57-65
    • Krum, J.M.1    Rosenstein, J.M.2
  • 47
    • 0037716760 scopus 로고    scopus 로고
    • Inhibition of endogenous VEGF impedes revascularization and astroglial proliferation: Roles for VEGF in brain repair
    • Krum JM. Khaibullina A. 2003 Inhibition of endogenous VEGF impedes revascularization and astroglial proliferation: roles for VEGF in brain repair ExpNeurol 181 241 257
    • (2003) ExpNeurol , vol.181 , pp. 241-257
    • Krum, J.M.1    Khaibullina, A.2
  • 48
    • 0037012467 scopus 로고    scopus 로고
    • Angiogenic and astroglial responses to vascular endothelial growth factor administration in adult rat brain
    • Krum JM. Mani N. Rosenstein JM. 2002 Angiogenic and astroglial responses to vascular endothelial growth factor administration in adult rat brain Neuroscience 110 589 604
    • (2002) Neuroscience , vol.110 , pp. 589-604
    • Krum, J.M.1    Mani, N.2    Rosenstein, J.M.3
  • 49
    • 0038475948 scopus 로고    scopus 로고
    • Vascular endothelial growth factor modulates the transendothelial migration of MDA-MB-231 breast cancer cells through regulation of brain microvascular endothelial cell permeability
    • Lee TH. Avraham HK. Jiang S. Avraham S. 2003 Vascular endothelial growth factor modulates the transendothelial migration of MDA-MB-231 breast cancer cells through regulation of brain microvascular endothelial cell permeability JBiolChem 278 5277 5284
    • (2003) JBiolChem , vol.278 , pp. 5277-5284
    • Lee, T.H.1    Avraham, H.K.2    Jiang, S.3    Avraham, S.4
  • 51
    • 2642569472 scopus 로고    scopus 로고
    • Neuroprotection of ischemic brain by vascular endothelial growth factor is critically dependent on proper dosage and may be compromised by angiogenesis
    • Manoonkitiwongsa PS. Schultz RL. McCreery DB. Whitter EF. Lyden PD. 2004 Neuroprotection of ischemic brain by vascular endothelial growth factor is critically dependent on proper dosage and may be compromised by angiogenesis JCerebBlood Flow Metab 24 693 702
    • (2004) JCerebBlood Flow Metab , vol.24 , pp. 693-702
    • Manoonkitiwongsa, P.S.1    Schultz, R.L.2    McCreery, D.B.3    Whitter, E.F.4    Lyden, P.D.5
  • 54
    • 0033902012 scopus 로고    scopus 로고
    • Hypoxia-induced vascular endothelial growth factor expression precedes neovascularization after cerebral ischemia
    • Marti HJ. Bernaudin M. Bellail A. Schoch H. Euler M. Petit E. Risau W. 2000 Hypoxia-induced vascular endothelial growth factor expression precedes neovascularization after cerebral ischemia AmJPathol 156 965 976
    • (2000) AmJPathol , vol.156 , pp. 965-976
    • Marti, H.J.1    Bernaudin, M.2    Bellail, A.3    Schoch, H.4    Euler, M.5    Petit, E.6    Risau, W.7
  • 55
  • 56
    • 0035344017 scopus 로고    scopus 로고
    • Vascular endothelial growth factor rescues hippocampal neurons from glutamate-induced toxicity: Signal transduction cascades
    • Matsuzaki H. Tamatani M. Yamaguchi A. Namikawa K. Kiyama H. Vitek MP. Mitsuda N. Tohyama M. 2001 Vascular endothelial growth factor rescues hippocampal neurons from glutamate-induced toxicity: signal transduction cascades Faseb J 15 1218 1220
    • (2001) Faseb J , vol.15 , pp. 1218-1220
    • Matsuzaki, H.1    Tamatani, M.2    Yamaguchi, A.3    Namikawa, K.4    Kiyama, H.5    Vitek, M.P.6    Mitsuda, N.7    Tohyama, M.8
  • 57
    • 0033028795 scopus 로고    scopus 로고
    • VEGF increases permeability of the blood-brain barrier via a nitric oxide synthase/cGMP-dependent pathway
    • Mayhan WG. 1999 VEGF increases permeability of the blood-brain barrier via a nitric oxide synthase/cGMP-dependent pathway AmJPhysiol 276 C1148 C1153
    • (1999) AmJPhysiol , vol.276
    • Mayhan, W.G.1
  • 59
    • 0027466849 scopus 로고
    • High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis
    • Millauer B. Wizigmann-Voos S. Schnurch H. Martinez R. Moller NP. Risau W. Ullrich A. 1993 High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis Cell 72 835 846
    • (1993) Cell , vol.72 , pp. 835-846
    • Millauer, B.1    Wizigmann-Voos, S.2    Schnurch, H.3    Martinez, R.4    Moller, N.P.5    Risau, W.6    Ullrich, A.7
  • 60
    • 0030755396 scopus 로고    scopus 로고
    • Role of vascular endothelial growth factor in blood-brain barrier breakdown and angiogenesis in brain trauma
    • Nag S. Takahashi JL. Kilty DW. 1997 Role of vascular endothelial growth factor in blood-brain barrier breakdown and angiogenesis in brain trauma JNeuropatholExpNeurol 56 912 921
    • (1997) JNeuropatholExpNeurol , vol.56 , pp. 912-921
    • Nag, S.1    Takahashi, J.L.2    Kilty, D.W.3
  • 61
    • 0037192788 scopus 로고    scopus 로고
    • Paracrine and autocrine functions of neuronal vascular endothelial growth factor (VEGF) in the central nervous system
    • 410-11 415
    • Ogunshola OO. Antic A. Donoghue MJ. Fan SY. Kim H. Stewart WB. Madri JA. Ment LR. 2002 Paracrine and autocrine functions of neuronal vascular endothelial growth factor (VEGF) in the central nervous system JBiolChem 277 11 410 11 415
    • (2002) JBiolChem , vol.277 , pp. 11
    • Ogunshola, O.O.1    Antic, A.2    Donoghue, M.J.3    Fan, S.Y.4    Kim, H.5    Stewart, W.B.6    Madri, J.A.7    Ment, L.R.8
  • 65
    • 0035000152 scopus 로고    scopus 로고
    • S-100 beta reflects the extent of injury and outcome, whereas neuronal specific enolase is a better indicator of neuroinflammation in patients with severe traumatic brain injury
    • Pleines UE. Morganti-Kossmann MC. Rancan M. Joller H. Trentz O. Kossmann T. 2001 S-100 beta reflects the extent of injury and outcome, whereas neuronal specific enolase is a better indicator of neuroinflammation in patients with severe traumatic brain injury JNeurotrauma 18 491 498
    • (2001) JNeurotrauma , vol.18 , pp. 491-498
    • Pleines, U.E.1    Morganti-Kossmann, M.C.2    Rancan, M.3    Joller, H.4    Trentz, O.5    Kossmann, T.6
  • 67
    • 0036794017 scopus 로고    scopus 로고
    • Vascular endothelial growth factor is expressed in multiple sclerosis plaques and can induce inflammatory lesions in experimental allergic encephalomyelitis rats
    • Proescholdt MA. Jacobson S. Tresser N. Oldfield EH. Merrill MJ. 2002 Vascular endothelial growth factor is expressed in multiple sclerosis plaques and can induce inflammatory lesions in experimental allergic encephalomyelitis rats JNeuropatholExpNeurol 61 914 925
    • (2002) JNeuropatholExpNeurol , vol.61 , pp. 914-925
    • Proescholdt, M.A.1    Jacobson, S.2    Tresser, N.3    Oldfield, E.H.4    Merrill, M.J.5
  • 68
    • 0030910881 scopus 로고    scopus 로고
    • Meningiomas: Role of vascular endothelial growth factor/vascular permeability factor in angiogenesis and peritumoral edema
    • Provias J. de Claffey KI. Aguila L. Lau N. Feldkamp M. Guha A. 1997 Meningiomas: role of vascular endothelial growth factor/vascular permeability factor in angiogenesis and peritumoral edema Neurosurgery 40 1016 1026
    • (1997) Neurosurgery , vol.40 , pp. 1016-1026
    • Provias, J.1    De Claffey, K.I.2    Aguila, L.3    Lau, N.4    Feldkamp, M.5    Guha, A.6
  • 69
    • 0034617285 scopus 로고    scopus 로고
    • Vascular endothelial growth factor up-regulates ICAM-1 expression via the phosphatidylinositol 3 OH-kinase/AKT/nitric oxide pathway and modulates migration of brain microvascular endothelial cells
    • 770-20 774
    • Radisavljevic Z. Avraham H. Avraham S. 2000 Vascular endothelial growth factor up-regulates ICAM-1 expression via the phosphatidylinositol 3 OH-kinase/AKT/nitric oxide pathway and modulates migration of brain microvascular endothelial cells JBiolChem 275 20 770 20 774
    • (2000) JBiolChem , vol.275 , pp. 20
    • Radisavljevic, Z.1    Avraham, H.2    Avraham, S.3
  • 70
    • 0031900714 scopus 로고    scopus 로고
    • Differentiation of blood-brain barrier endothelial cells
    • Risau W. Esser S. Engelhardt B. 1998 Differentiation of blood-brain barrier endothelial cells PatholBiol(Paris) 46 171 175
    • (1998) PatholBiol(Paris) , vol.46 , pp. 171-175
    • Risau, W.1    Esser, S.2    Engelhardt, B.3
  • 71
    • 0033852159 scopus 로고    scopus 로고
    • Traumatic brain damage: Serum S-100 protein measurements related to neuroradiological findings
    • Romner B. Ingebrigtsen T. Kongstad P. Borgesen SE. 2000 Traumatic brain damage: serum S-100 protein measurements related to neuroradiological findings JNeurotrauma 17 641 647
    • (2000) JNeurotrauma , vol.17 , pp. 641-647
    • Romner, B.1    Ingebrigtsen, T.2    Kongstad, P.3    Borgesen, S.E.4
  • 72
    • 0032499694 scopus 로고    scopus 로고
    • Patterns of brain angiogenesis after vascular endothelial growth factor administration in vitro and in vivo
    • Rosenstein JM. Mani N. Silverman WF. Krum JM. 1998 Patterns of brain angiogenesis after vascular endothelial growth factor administration in vitro and in vivo ProcNatl AcadSciUSA 95 7086 7091
    • (1998) ProcNatl AcadSciUSA , vol.95 , pp. 7086-7091
    • Rosenstein, J.M.1    Mani, N.2    Silverman, W.F.3    Krum, J.M.4
  • 73
    • 0346118855 scopus 로고    scopus 로고
    • Neurotrophic effects of vascular endothelial growth factor on organotypic cortical explants and primary cortical neurons
    • Rosenstein JM. Mani N. Khaibullina A. Krum JM. 2003 Neurotrophic effects of vascular endothelial growth factor on organotypic cortical explants and primary cortical neurons JNeurosci 23 11036 11044
    • (2003) JNeurosci , vol.23 , pp. 11036-11044
    • Rosenstein, J.M.1    Mani, N.2    Khaibullina, A.3    Krum, J.M.4
  • 75
    • 3142626380 scopus 로고    scopus 로고
    • Effects of head and extracranial injuries on serum protein S100B levels in trauma patients
    • ; discussion 1234
    • Savola O. Pyhtinen J. Leino TK. Siitonen S. Niemela O. Hillbom M. 2004 Effects of head and extracranial injuries on serum protein S100B levels in trauma patients JTrauma 56 1229 1234 ; discussion 1234
    • (2004) JTrauma , vol.56 , pp. 1229-1234
    • Savola, O.1    Pyhtinen, J.2    Leino, T.K.3    Siitonen, S.4    Niemela, O.5    Hillbom, M.6
  • 76
    • 1842586172 scopus 로고    scopus 로고
    • Cerebral ischemia and reperfusion: The pathophysiologic concept as a basis for clinical therapy
    • Schaller B. Graf R. 2004 Cerebral ischemia and reperfusion: the pathophysiologic concept as a basis for clinical therapy JCerebBlood Flow Metab 24 351 371
    • (2004) JCerebBlood Flow Metab , vol.24 , pp. 351-371
    • Schaller, B.1    Graf, R.2
  • 77
    • 4544314167 scopus 로고    scopus 로고
    • Locomotion of monocytes on endothelium is a critical step during extravasation
    • Schenkel AR. Mamdouh Z. Muller WA. 2004 Locomotion of monocytes on endothelium is a critical step during extravasation NatImmunol 5 393 400
    • (2004) NatImmunol , vol.5 , pp. 393-400
    • Schenkel, A.R.1    Mamdouh, Z.2    Muller, W.A.3
  • 78
    • 0030901162 scopus 로고    scopus 로고
    • Fluoro-Jade: A novel fluorochrome for the sensitive and reliable histochemical localization of neuronal degeneration
    • Schmued LC. Albertson C. Slikker W. Jr. 1997 Fluoro-Jade: a novel fluorochrome for the sensitive and reliable histochemical localization of neuronal degeneration Brain Res 751 37 46
    • (1997) Brain Res , vol.751 , pp. 37-46
    • Schmued, L.C.1    Albertson, C.2    Slikker Jr., W.3
  • 79
    • 0036846795 scopus 로고    scopus 로고
    • Hypoxia-induced vascular endothelial growth factor expression causes vascular leakage in the brain
    • Schoch HJ. Fischer S. Marti HH. 2002 Hypoxia-induced vascular endothelial growth factor expression causes vascular leakage in the brain Brain 125 2549 2557
    • (2002) Brain , vol.125 , pp. 2549-2557
    • Schoch, H.J.1    Fischer, S.2    Marti, H.H.3
  • 80
    • 0037070170 scopus 로고    scopus 로고
    • Identification of functional VEGF receptors on human platelets
    • Selheim F. Holmsen H. Vassbotn FS. 2002 Identification of functional VEGF receptors on human platelets FEBS Lett 512 107 110
    • (2002) FEBS Lett , vol.512 , pp. 107-110
    • Selheim, F.1    Holmsen, H.2    Vassbotn, F.S.3
  • 81
    • 0021111648 scopus 로고
    • Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid
    • Senger DR. Galli SJ. Dvorak AM. Perruzzi CA. Harvey VS. Dvorak HF. 1983 Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid Science 219 983 985
    • (1983) Science , vol.219 , pp. 983-985
    • Senger, D.R.1    Galli, S.J.2    Dvorak, A.M.3    Perruzzi, C.A.4    Harvey, V.S.5    Dvorak, H.F.6
  • 82
    • 0032903416 scopus 로고    scopus 로고
    • Vascular, glial and neuronal effects of vascular endothelial growth factor in mesencephalic explant cultures
    • Silverman WF. Krum JM. Mani N. Rosenstein JM. 1999 Vascular, glial and neuronal effects of vascular endothelial growth factor in mesencephalic explant cultures Neuroscience 90 1529 1541
    • (1999) Neuroscience , vol.90 , pp. 1529-1541
    • Silverman, W.F.1    Krum, J.M.2    Mani, N.3    Rosenstein, J.M.4
  • 84
    • 3442886827 scopus 로고    scopus 로고
    • Induction of HIF1alpha but not HIF2alpha in motoneurons after ventral funiculus axotomy-implication in neuronal survival strategies
    • Sköld MK. Marti HH. Lindholm T. Linda H. Hammarberg H. Risling M. Cullheim S. 2004 Induction of HIF1alpha but not HIF2alpha in motoneurons after ventral funiculus axotomy-implication in neuronal survival strategies ExpNeurol 188 20 32
    • (2004) ExpNeurol , vol.188 , pp. 20-32
    • Sköld, M.K.1    Marti, H.H.2    Lindholm, T.3    Linda, H.4    Hammarberg, H.5    Risling, M.6    Cullheim, S.7
  • 86
    • 0033565417 scopus 로고    scopus 로고
    • Vascular endothelial growth factor has neurotrophic activity and stimulates axonal outgrowth, enhancing cell survival and Schwann cell proliferation in the peripheral nervous system
    • Sondell M. Lundborg G. Kanje M. 1999 Vascular endothelial growth factor has neurotrophic activity and stimulates axonal outgrowth, enhancing cell survival and Schwann cell proliferation in the peripheral nervous system JNeurosci 19 5731 5740
    • (1999) JNeurosci , vol.19 , pp. 5731-5740
    • Sondell, M.1    Lundborg, G.2    Kanje, M.3
  • 87
    • 0034502527 scopus 로고    scopus 로고
    • Vascular endothelial growth factor is a neurotrophic factor which stimulates axonal outgrowth through the flk-1 receptor
    • Sondell M. Sundler F. Kanje M. 2000 Vascular endothelial growth factor is a neurotrophic factor which stimulates axonal outgrowth through the flk-1 receptor EurJNeurosci 12 4243 4254
    • (2000) EurJNeurosci , vol.12 , pp. 4243-4254
    • Sondell, M.1    Sundler, F.2    Kanje, M.3
  • 88
    • 0032407132 scopus 로고    scopus 로고
    • Association of S100B with intermediate filaments and microtubules in glial cells
    • Sorci G. Agneletti AL. Bianchi R. Donato R. 1998 Association of S100B with intermediate filaments and microtubules in glial cells BiochimBiophysActa 1448 277 289
    • (1998) BiochimBiophysActa , vol.1448 , pp. 277-289
    • Sorci, G.1    Agneletti, A.L.2    Bianchi, R.3    Donato, R.4
  • 90
    • 0041743159 scopus 로고    scopus 로고
    • VEGF-induced neuroprotection, neurogenesis, and angiogenesis after focal cerebral ischemia
    • Sun Y. Jin K. Xie L. Childs J. Mao XO. Logvinova A. Greenberg DA. 2003 VEGF-induced neuroprotection, neurogenesis, and angiogenesis after focal cerebral ischemia JClinInvest 111 1843 1851
    • (2003) JClinInvest , vol.111 , pp. 1843-1851
    • Sun, Y.1    Jin, K.2    Xie, L.3    Childs, J.4    Mao, X.O.5    Logvinova, A.6    Greenberg, D.A.7
  • 91
    • 0035700915 scopus 로고    scopus 로고
    • Flk-1 specific kinase inhibitor (SU5416) inhibited the growth of GS-9L glioma in rat brain and prolonged the survival
    • Takamoto T. Sasaki M. Kuno T. Tamaki N. 2001 Flk-1 specific kinase inhibitor (SU5416) inhibited the growth of GS-9L glioma in rat brain and prolonged the survival Kobe JMedSci 47 181 191
    • (2001) Kobe JMedSci , vol.47 , pp. 181-191
    • Takamoto, T.1    Sasaki, M.2    Kuno, T.3    Tamaki, N.4
  • 92
    • 0036008007 scopus 로고    scopus 로고
    • Labelling of rat endothelial cells with antibodies to vWF, RECA-1, PECAM-1, ICAM-1, OX-43 and ZO-1
    • Ulger H. Karabulut AK. Pratten MK. 2002 Labelling of rat endothelial cells with antibodies to vWF, RECA-1, PECAM-1, ICAM-1, OX-43 and ZO-1 AnatHistolEmbryol 31 31 35
    • (2002) AnatHistolEmbryol , vol.31 , pp. 31-35
    • Ulger, H.1    Karabulut, A.K.2    Pratten, M.K.3
  • 93
    • 18844424905 scopus 로고    scopus 로고
    • Stabilization of the retinal vascular network by reciprocal feedback between blood vessels and astrocytes
    • West H. Richardson WD. Fruttiger M. 2005 Stabilization of the retinal vascular network by reciprocal feedback between blood vessels and astrocytes Development 132 1855 1862
    • (2005) Development , vol.132 , pp. 1855-1862
    • West, H.1    Richardson, W.D.2    Fruttiger, M.3
  • 94
    • 0042133340 scopus 로고    scopus 로고
    • Vascular endothelial growth factor improves functional outcome and decreases secondary degeneration in experimental spinal cord contusion injury
    • Widenfalk J. Lipson A. Jubran M. Hofstetter C. Ebendal T. Cao Y. Olson L. 2003 Vascular endothelial growth factor improves functional outcome and decreases secondary degeneration in experimental spinal cord contusion injury Neuroscience 120 951 960
    • (2003) Neuroscience , vol.120 , pp. 951-960
    • Widenfalk, J.1    Lipson, A.2    Jubran, M.3    Hofstetter, C.4    Ebendal, T.5    Cao, Y.6    Olson, L.7
  • 95
    • 0036173275 scopus 로고    scopus 로고
    • Vascular endothelial growth factor and angiopoietins in focal cerebral ischemia
    • Zhang Z. Chopp M. 2002 Vascular endothelial growth factor and angiopoietins in focal cerebral ischemia Trends CardiovascMed 12 62 66
    • (2002) Trends CardiovascMed , vol.12 , pp. 62-66
    • Zhang, Z.1    Chopp, M.2
  • 97
    • 0030760110 scopus 로고    scopus 로고
    • Microvascular responses to cerebral ischemia/inflammation
    • del Zoppo GJ. 1997 Microvascular responses to cerebral ischemia/inflammation AnnNYAcadSci 823 132 147
    • (1997) AnnNYAcadSci , vol.823 , pp. 132-147
    • Del Zoppo, G.J.1


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