메뉴 건너뛰기




Volumn 58, Issue 9, 2010, Pages 1749-1757

The blood-brain barrier: Geriatric relevance of a critical brain-body interface

Author keywords

blood brain barrier; delirium; dementia; pharmacology; stroke

Indexed keywords

GELATINASE B; GLUCOSE TRANSPORTER; PROTEIN ZO1; PROTEIN ZO2;

EID: 77956326640     PISSN: 00028614     EISSN: 15325415     Source Type: Journal    
DOI: 10.1111/j.1532-5415.2010.03011.x     Document Type: Review
Times cited : (98)

References (53)
  • 1
    • 57749193067 scopus 로고    scopus 로고
    • Brain endothelial cells and the glio-vascular complex
    • Wolburg H, Noell S, Mack A et al. Brain endothelial cells and the glio-vascular complex. Cell Tissue Res 2009 335 : 75 96.
    • (2009) Cell Tissue Res , vol.335 , pp. 75-96
    • Wolburg, H.1    Noell, S.2    MacK, A.3
  • 2
    • 58549098084 scopus 로고    scopus 로고
    • Blood-brain barrier: Ageing and microvascular disease - Systematic review and meta-analysis
    • Farrall AJ, Wardlaw JM. Blood-brain barrier: Ageing and microvascular disease - systematic review and meta-analysis. Neurobiol Aging 2009 30 : 337 352.
    • (2009) Neurobiol Aging , vol.30 , pp. 337-352
    • Farrall, A.J.1    Wardlaw, J.M.2
  • 3
    • 37149034911 scopus 로고    scopus 로고
    • Strategies to advance translational research into brain barriers
    • Neuwelt E, Abbott NJ, Abrey L et al. Strategies to advance translational research into brain barriers. Lancet Neurol 2008 7 : 84 96.
    • (2008) Lancet Neurol , vol.7 , pp. 84-96
    • Neuwelt, E.1    Abbott, N.J.2    Abrey, L.3
  • 4
    • 14144255054 scopus 로고    scopus 로고
    • Where is the blood-brain barrier ... really?
    • Ge S, Song L, Pachter JS. Where is the blood-brain barrier... really? J Neurosci Res 2005 79 : 421 427.
    • (2005) J Neurosci Res , vol.79 , pp. 421-427
    • Ge, S.1    Song, L.2    Pachter, J.S.3
  • 5
    • 33747368249 scopus 로고    scopus 로고
    • Blood-brain barrier: Structural components and function under physiologic and pathologic conditions
    • Persidsky Y, Ramirez SH, Haorah J et al. Blood-brain barrier: Structural components and function under physiologic and pathologic conditions. J Neuroimmune Pharmacol 2006 1 : 223 236.
    • (2006) J Neuroimmune Pharmacol , vol.1 , pp. 223-236
    • Persidsky, Y.1    Ramirez, S.H.2    Haorah, J.3
  • 6
    • 22944483792 scopus 로고    scopus 로고
    • The blood-brain barrier/neurovascular unit in health and disease
    • Hawkins BT, Davis TP. The blood-brain barrier/neurovascular unit in health and disease. Pharmacol Rev 2005 57 : 173 185.
    • (2005) Pharmacol Rev , vol.57 , pp. 173-185
    • Hawkins, B.T.1    Davis, T.P.2
  • 7
    • 34547645047 scopus 로고    scopus 로고
    • Modelling of the blood-brain barrier in drug discovery and development
    • Cecchelli R, Berezowski V, Lundquist S et al. Modelling of the blood-brain barrier in drug discovery and development. Nat Rev Drug Discov 2007 6 : 650 661.
    • (2007) Nat Rev Drug Discov , vol.6 , pp. 650-661
    • Cecchelli, R.1    Berezowski, V.2    Lundquist, S.3
  • 8
    • 77952035085 scopus 로고    scopus 로고
    • Endothelial cell heterogeneity of blood-brain barrier gene expression along the cerebral microvasculature
    • Macdonald JA, Murugesan N, Pachter JS. Endothelial cell heterogeneity of blood-brain barrier gene expression along the cerebral microvasculature. J Neurosci Res 2009 88 : 1457 1474.
    • (2009) J Neurosci Res , vol.88 , pp. 1457-1474
    • MacDonald, J.A.1    Murugesan, N.2    Pachter, J.S.3
  • 9
    • 34548305271 scopus 로고    scopus 로고
    • Increased permeability of blood-brain barrier on the hippocampus of a murine model of senescence
    • Pelegri C, Canudas AM, del Valle J et al. Increased permeability of blood-brain barrier on the hippocampus of a murine model of senescence. Mech Ageing Dev 2007 128 : 522 528.
    • (2007) Mech Ageing Dev , vol.128 , pp. 522-528
    • Pelegri, C.1    Canudas, A.M.2    Del Valle, J.3
  • 10
    • 34249040510 scopus 로고    scopus 로고
    • Blood-brain barrier impairment in Alzheimer disease: Stability and functional significance
    • Bowman GL, Kaye JA, Moore M et al. Blood-brain barrier impairment in Alzheimer disease: Stability and functional significance. Neurology 2007 68 : 1809 1814.
    • (2007) Neurology , vol.68 , pp. 1809-1814
    • Bowman, G.L.1    Kaye, J.A.2    Moore, M.3
  • 11
    • 0030812065 scopus 로고    scopus 로고
    • Age-related changes in the blood-brain barrier
    • Shah GN, Mooradian AD. Age-related changes in the blood-brain barrier. Exp Gerontol 1997 32 : 501 519.
    • (1997) Exp Gerontol , vol.32 , pp. 501-519
    • Shah, G.N.1    Mooradian, A.D.2
  • 12
    • 53049101053 scopus 로고    scopus 로고
    • Neuropathologic correlates of white matter hyperintensities
    • Young VG, Halliday GM, Kril JJ. Neuropathologic correlates of white matter hyperintensities. Neurology 2008 71 : 804 811.
    • (2008) Neurology , vol.71 , pp. 804-811
    • Young, V.G.1    Halliday, G.M.2    Kril, J.J.3
  • 13
    • 34249790312 scopus 로고    scopus 로고
    • Vascular dementia in leukoaraiosis may be a consequence of capillary loss not only in the lesions, but in normal-appearing white matter and cortex as well
    • Brown WR, Moody DM, Thore CR et al. Vascular dementia in leukoaraiosis may be a consequence of capillary loss not only in the lesions, but in normal-appearing white matter and cortex as well. J Neurol Sci 2007 257 : 62 66.
    • (2007) J Neurol Sci , vol.257 , pp. 62-66
    • Brown, W.R.1    Moody, D.M.2    Thore, C.R.3
  • 14
    • 0028007359 scopus 로고
    • Potential mechanisms of the age-related changes in the blood-brain barrier
    • discussion 761-752, 767.
    • Mooradian AD. Potential mechanisms of the age-related changes in the blood-brain barrier. Neurobiol Aging 1994 15 : 751 755 discussion 761-752, 767.
    • (1994) Neurobiol Aging , vol.15 , pp. 751-755
    • Mooradian, A.D.1
  • 15
    • 0031705997 scopus 로고    scopus 로고
    • Aging and cerebrovascular disease
    • Choi JY, Morris JC, Hsu CY. Aging and cerebrovascular disease. Neurol Clin 1998 16 : 687 711.
    • (1998) Neurol Clin , vol.16 , pp. 687-711
    • Choi, J.Y.1    Morris, J.C.2    Hsu, C.Y.3
  • 16
    • 33744936006 scopus 로고    scopus 로고
    • Effect of age on functional P-glycoprotein in the blood-brain barrier measured by use of (R)-[(11)C]verapamil and positron emission tomography
    • Toornvliet R, van Berckel BN, Luurtsema G et al. Effect of age on functional P-glycoprotein in the blood-brain barrier measured by use of (R)-[(11)C]verapamil and positron emission tomography. Clin Pharmacol Ther 2006 79 : 540 548.
    • (2006) Clin Pharmacol Ther , vol.79 , pp. 540-548
    • Toornvliet, R.1    Van Berckel, B.N.2    Luurtsema, G.3
  • 17
    • 70049084419 scopus 로고    scopus 로고
    • Blood-brain barrier P-glycoprotein function decreases in specific brain regions with aging: A possible role in progressive neurodegeneration
    • Bartels AL, Kortekaas R, Bart J et al. Blood-brain barrier P-glycoprotein function decreases in specific brain regions with aging: A possible role in progressive neurodegeneration. Neurobiol Aging 2008 30 : 1818 1824.
    • (2008) Neurobiol Aging , vol.30 , pp. 1818-1824
    • Bartels, A.L.1    Kortekaas, R.2    Bart, J.3
  • 18
    • 4544322402 scopus 로고    scopus 로고
    • The aging brain: Morphomolecular senescence of cortical circuits
    • Hof PR, Morrison JH. The aging brain: Morphomolecular senescence of cortical circuits. Trends Neurosci 2004 27 : 607 613.
    • (2004) Trends Neurosci , vol.27 , pp. 607-613
    • Hof, P.R.1    Morrison, J.H.2
  • 19
    • 0025141691 scopus 로고
    • Age related changes in the effect of electroconvulsive shock on the blood brain barrier permeability in rats
    • Oztas B, Kaya M, Camurcu S. Age related changes in the effect of electroconvulsive shock on the blood brain barrier permeability in rats. Mech Ageing Dev 1990 51 : 149 155.
    • (1990) Mech Ageing Dev , vol.51 , pp. 149-155
    • Oztas, B.1    Kaya, M.2    Camurcu, S.3
  • 20
    • 56649103770 scopus 로고    scopus 로고
    • Do in vivo experimental models reflect human cerebral small vessel disease? A systematic review
    • Hainsworth AH, Markus HS. Do in vivo experimental models reflect human cerebral small vessel disease? A systematic review. J Cereb Blood Flow Metab 2008 28 : 1877 1891.
    • (2008) J Cereb Blood Flow Metab , vol.28 , pp. 1877-1891
    • Hainsworth, A.H.1    Markus, H.S.2
  • 21
    • 40849113545 scopus 로고    scopus 로고
    • Early disruptions of the blood-brain barrier may contribute to exacerbated neuronal damage and prolonged functional recovery following stroke in aged rats
    • DiNapoli VA, Huber JD, Houser K et al. Early disruptions of the blood-brain barrier may contribute to exacerbated neuronal damage and prolonged functional recovery following stroke in aged rats. Neurobiol Aging 2008 29 : 753 764.
    • (2008) Neurobiol Aging , vol.29 , pp. 753-764
    • Dinapoli, V.A.1    Huber, J.D.2    Houser, K.3
  • 22
    • 42049122347 scopus 로고    scopus 로고
    • The blood-brain barrier is continuously open for several weeks following transient focal cerebral ischemia
    • Strbian D, Durukan A, Pitkonen M et al. The blood-brain barrier is continuously open for several weeks following transient focal cerebral ischemia. Neuroscience 2008 153 : 175 181.
    • (2008) Neuroscience , vol.153 , pp. 175-181
    • Strbian, D.1    Durukan, A.2    Pitkonen, M.3
  • 23
    • 4844223991 scopus 로고    scopus 로고
    • Early blood-brain barrier disruption in human focal brain ischemia
    • Latour LL, Kang DW, Ezzeddine MA et al. Early blood-brain barrier disruption in human focal brain ischemia. Ann Neurol 2004 56 : 468 477.
    • (2004) Ann Neurol , vol.56 , pp. 468-477
    • Latour, L.L.1    Kang, D.W.2    Ezzeddine, M.A.3
  • 24
    • 1542472724 scopus 로고    scopus 로고
    • Correlation of 99mTc-DTPA SPECT of the blood-brain barrier with neurologic outcome after acute stroke
    • Lorberboym M, Lampl Y, Sadeh M. Correlation of 99mTc-DTPA SPECT of the blood-brain barrier with neurologic outcome after acute stroke. J Nucl Med 2003 44 : 1898 1904.
    • (2003) J Nucl Med , vol.44 , pp. 1898-1904
    • Lorberboym, M.1    Lampl, Y.2    Sadeh, M.3
  • 25
    • 24644517524 scopus 로고    scopus 로고
    • The prediction of malignant cerebral infarction by molecular brain barrier disruption markers
    • Serena J, Blanco M, Castellanos M et al. The prediction of malignant cerebral infarction by molecular brain barrier disruption markers. Stroke 2005 36 : 1921 1926.
    • (2005) Stroke , vol.36 , pp. 1921-1926
    • Serena, J.1    Blanco, M.2    Castellanos, M.3
  • 26
    • 2542501568 scopus 로고    scopus 로고
    • Transcellular transport as a mechanism of blood-brain barrier disruption during stroke
    • Cipolla MJ, Crete R, Vitullo L et al. Transcellular transport as a mechanism of blood-brain barrier disruption during stroke. Front Biosci 2004 9 : 777 785.
    • (2004) Front Biosci , vol.9 , pp. 777-785
    • Cipolla, M.J.1    Crete, R.2    Vitullo, L.3
  • 27
    • 0034054903 scopus 로고    scopus 로고
    • Age-dependent increase in infarct volume following photochemically induced cerebral infarction: Putative role of astroglia
    • discussion B142-133.
    • Kharlamov A, Kharlamov E, Armstrong DM. Age-dependent increase in infarct volume following photochemically induced cerebral infarction: Putative role of astroglia. J Gerontol A Biol Sci Med Sci 2000 55A : B135 B141 discussion B142-133.
    • (2000) J Gerontol A Biol Sci Med Sci , vol.55
    • Kharlamov, A.1    Kharlamov, E.2    Armstrong, D.M.3
  • 28
    • 58149357031 scopus 로고    scopus 로고
    • Systemic inflammation alters the kinetics of cerebrovascular tight junction disruption after experimental stroke in mice
    • McColl BW, Rothwell NJ, Allan SM. Systemic inflammation alters the kinetics of cerebrovascular tight junction disruption after experimental stroke in mice. J Neurosci 2008 28 : 9451 9462.
    • (2008) J Neurosci , vol.28 , pp. 9451-9462
    • McColl, B.W.1    Rothwell, N.J.2    Allan, S.M.3
  • 29
    • 33744913541 scopus 로고    scopus 로고
    • Research agenda for frailty in older adults: Toward a better understanding of physiology and etiology: Summary from the American Geriatrics Society/National Institute on Aging Research Conference on Frailty in Older Adults
    • Walston J, Hadley EC, Ferrucci L et al. Research agenda for frailty in older adults: Toward a better understanding of physiology and etiology: Summary from the American Geriatrics Society/National Institute on Aging Research Conference on Frailty in Older Adults. J Am Geriatr Soc 2006 54 : 991 1001.
    • (2006) J Am Geriatr Soc , vol.54 , pp. 991-1001
    • Walston, J.1    Hadley, E.C.2    Ferrucci, L.3
  • 30
    • 62549145764 scopus 로고    scopus 로고
    • Lacunar stroke is associated with diffuse blood-brain barrier dysfunction
    • Wardlaw JM, Doubal F, Armitage P et al. Lacunar stroke is associated with diffuse blood-brain barrier dysfunction. Ann Neurol 2009 65 : 194 202.
    • (2009) Ann Neurol , vol.65 , pp. 194-202
    • Wardlaw, J.M.1    Doubal, F.2    Armitage, P.3
  • 32
    • 63949087486 scopus 로고    scopus 로고
    • Changes in experimental stroke outcome across the life span
    • Liu F, Yuan R, Benashski SE et al. Changes in experimental stroke outcome across the life span. J Cereb Blood Flow Metab 2009 29 : 792 802.
    • (2009) J Cereb Blood Flow Metab , vol.29 , pp. 792-802
    • Liu, F.1    Yuan, R.2    Benashski, S.E.3
  • 33
    • 43549115447 scopus 로고    scopus 로고
    • Reproductive hormones regulate the selective permeability of the blood-brain barrier
    • Wilson AC, Clemente L, Liu T et al. Reproductive hormones regulate the selective permeability of the blood-brain barrier. Biochim Biophys Acta 2008 1782 : 401 407.
    • (2008) Biochim Biophys Acta , vol.1782 , pp. 401-407
    • Wilson, A.C.1    Clemente, L.2    Liu, T.3
  • 34
    • 0037125379 scopus 로고    scopus 로고
    • Risks and benefits of estrogen plus progestin in healthy postmenopausal women: Principal results from the Women's Health Initiative randomized controlled trial
    • Rossouw JE, Anderson GL, Prentice RL et al. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: Principal results from the Women's Health Initiative randomized controlled trial. JAMA 2002 288 : 321 333.
    • (2002) JAMA , vol.288 , pp. 321-333
    • Rossouw, J.E.1    Anderson, G.L.2    Prentice, R.L.3
  • 35
    • 0028255888 scopus 로고
    • Cerebral lesions on magnetic resonance imaging, heart disease, and vascular risk factors in subjects without stroke. A population-based study
    • Lindgren A, Roijer A, Rudling O et al. Cerebral lesions on magnetic resonance imaging, heart disease, and vascular risk factors in subjects without stroke. A population-based study. Stroke 1994 25 : 929 934.
    • (1994) Stroke , vol.25 , pp. 929-934
    • Lindgren, A.1    Roijer, A.2    Rudling, O.3
  • 36
    • 17844371310 scopus 로고    scopus 로고
    • Accrual of MRI white matter abnormalities in elderly with normal and impaired mobility
    • Wolfson L, Wei X, Hall CB et al. Accrual of MRI white matter abnormalities in elderly with normal and impaired mobility. J Neurol Sci 2005 232 : 23 27.
    • (2005) J Neurol Sci , vol.232 , pp. 23-27
    • Wolfson, L.1    Wei, X.2    Hall, C.B.3
  • 37
    • 67650663283 scopus 로고    scopus 로고
    • Localization of brain white matter hyperintensities and urinary incontinence in community-dwelling older adults
    • Kuchel GA, Moscufo N, Guttmann CR et al. Localization of brain white matter hyperintensities and urinary incontinence in community-dwelling older adults. J Gerontol A Biol Sci Med Sci 2009 64A : 902 909.
    • (2009) J Gerontol A Biol Sci Med Sci , vol.64 , pp. 902-909
    • Kuchel, G.A.1    Moscufo, N.2    Guttmann, C.R.3
  • 38
    • 0035836741 scopus 로고    scopus 로고
    • Longitudinal study of blood pressure and white matter hyperintensities: The EVA MRI Cohort
    • Dufouil C, de Kersaint-Gilly A, Besancon V et al. Longitudinal study of blood pressure and white matter hyperintensities: The EVA MRI Cohort. Neurology 2001 56 : 921 926.
    • (2001) Neurology , vol.56 , pp. 921-926
    • Dufouil, C.1    De Kersaint-Gilly, A.2    Besancon, V.3
  • 39
    • 0037312568 scopus 로고    scopus 로고
    • Markers of endothelial dysfunction in lacunar infarction and ischaemic leukoaraiosis
    • Hassan A, Hunt BJ, O'Sullivan M et al. Markers of endothelial dysfunction in lacunar infarction and ischaemic leukoaraiosis. Brain 2003 126 : 424 432.
    • (2003) Brain , vol.126 , pp. 424-432
    • Hassan, A.1    Hunt, B.J.2    O'Sullivan, M.3
  • 40
    • 0036277901 scopus 로고    scopus 로고
    • Increased blood-brain barrier permeability in white matter lesions of Binswanger's disease evaluated by contrast-enhanced MRI
    • Hanyu H, Asano T, Tanaka Y et al. Increased blood-brain barrier permeability in white matter lesions of Binswanger's disease evaluated by contrast-enhanced MRI. Dement Geriatr Cogn Disord 2002 14 : 1 6.
    • (2002) Dement Geriatr Cogn Disord , vol.14 , pp. 1-6
    • Hanyu, H.1    Asano, T.2    Tanaka, Y.3
  • 41
    • 34447134893 scopus 로고    scopus 로고
    • White matter lesions in an unselected cohort of the elderly: Astrocytic, microglial and oligodendrocyte precursor cell responses
    • Simpson JE, Fernando MS, Clark L et al. White matter lesions in an unselected cohort of the elderly: Astrocytic, microglial and oligodendrocyte precursor cell responses. Neuropathol Appl Neurobiol 2007 33 : 410 419.
    • (2007) Neuropathol Appl Neurobiol , vol.33 , pp. 410-419
    • Simpson, J.E.1    Fernando, M.S.2    Clark, L.3
  • 43
    • 33846451414 scopus 로고    scopus 로고
    • The role of neuroimaging in elucidating delirium pathophysiology
    • Alsop DC, Fearing MA, Johnson K et al. The role of neuroimaging in elucidating delirium pathophysiology. J Gerontol A Biol Sci Med Sci 2006 61A : 1287 1293.
    • (2006) J Gerontol A Biol Sci Med Sci , vol.61 , pp. 1287-1293
    • Alsop, D.C.1    Fearing, M.A.2    Johnson, K.3
  • 44
    • 0029019093 scopus 로고
    • Shared risk factors for falls, incontinence, and functional dependence. Unifying the approach to geriatric syndromes
    • Tinetti ME, Inouye SK, Gill TM et al. Shared risk factors for falls, incontinence, and functional dependence. Unifying the approach to geriatric syndromes. JAMA 1995 273 : 1348 1353.
    • (1995) JAMA , vol.273 , pp. 1348-1353
    • Tinetti, M.E.1    Inouye, S.K.2    Gill, T.M.3
  • 45
    • 34247578803 scopus 로고    scopus 로고
    • Geriatric syndromes: Clinical, research, and policy implications of a core geriatric concept
    • Inouye SK, Studenski S, Tinetti ME et al. Geriatric syndromes: Clinical, research, and policy implications of a core geriatric concept. J Am Geriatr Soc 2007 55 : 780 791.
    • (2007) J Am Geriatr Soc , vol.55 , pp. 780-791
    • Inouye, S.K.1    Studenski, S.2    Tinetti, M.E.3
  • 47
    • 27644570209 scopus 로고    scopus 로고
    • CCR2 expression by brain microvascular endothelial cells is critical for macrophage transendothelial migration in response to CCL2
    • Dzenko KA, Song L, Ge S et al. CCR2 expression by brain microvascular endothelial cells is critical for macrophage transendothelial migration in response to CCL2. Microvasc Res 2005 70 : 53 64.
    • (2005) Microvasc Res , vol.70 , pp. 53-64
    • Dzenko, K.A.1    Song, L.2    Ge, S.3
  • 48
    • 39749175539 scopus 로고    scopus 로고
    • Transcellular transport of CCL2 across brain microvascular endothelial cells
    • Ge S, Song L, Serwanski DR et al. Transcellular transport of CCL2 across brain microvascular endothelial cells. J Neurochem 2008 104 : 1219 1232.
    • (2008) J Neurochem , vol.104 , pp. 1219-1232
    • Ge, S.1    Song, L.2    Serwanski, D.R.3
  • 49
    • 34748874678 scopus 로고    scopus 로고
    • Pharmacokinetic-pharmacodynamic crisis in the elderly
    • ElDesoky ES. Pharmacokinetic-pharmacodynamic crisis in the elderly. Am J Ther 2007 14 : 488 498.
    • (2007) Am J Ther , vol.14 , pp. 488-498
    • Eldesoky, E.S.1
  • 50
    • 29344466431 scopus 로고    scopus 로고
    • Antimuscarinic drugs for overactive bladder and their potential effects on cognitive function in older patients
    • Kay GG, Abou-Donia MB, Messer WS Jr. et al. Antimuscarinic drugs for overactive bladder and their potential effects on cognitive function in older patients. J Am Geriatr Soc 2005 53 : 2195 2201.
    • (2005) J Am Geriatr Soc , vol.53 , pp. 2195-2201
    • Kay, G.G.1    Abou-Donia, M.B.2    Messer, Jr.W.S.3
  • 51
    • 14144252093 scopus 로고    scopus 로고
    • Effects on sleep of anticholinergics used for overactive bladder treatment in healthy volunteers aged>or=50 years
    • Diefenbach K, Arold G, Wollny A et al. Effects on sleep of anticholinergics used for overactive bladder treatment in healthy volunteers aged>or=50 years. BJU Int 2005 95 : 346 349.
    • (2005) BJU Int , vol.95 , pp. 346-349
    • Diefenbach, K.1    Arold, G.2    Wollny, A.3
  • 52
    • 0021956221 scopus 로고
    • Pattern of CNS recovery following reversal of neuromuscular blockade. Comparison of atropine and glycopyrrolate
    • Sheref SE. Pattern of CNS recovery following reversal of neuromuscular blockade. Comparison of atropine and glycopyrrolate. Br J Anaesth 1985 57 : 188 191.
    • (1985) Br J Anaesth , vol.57 , pp. 188-191
    • Sheref, S.E.1
  • 53
    • 0026579601 scopus 로고
    • Ageing influences haloperidol-induced changes in the permeability of the blood-brain barrier in the rat
    • Saija A, Princi P, Imperatore C et al. Ageing influences haloperidol-induced changes in the permeability of the blood-brain barrier in the rat. J Pharm Pharmacol 1992 44 : 450 452.
    • (1992) J Pharm Pharmacol , vol.44 , pp. 450-452
    • Saija, A.1    Princi, P.2    Imperatore, C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.