Novel non-competitive antagonists of kainate GluK1/GluK2 receptors

Letters in Drug Design and Discovery

Volumn 9, Issue 10, 2012, Pages 891-898

  Kaczor, Agnieszka Anna ^a   Kronbach, Christiane ^b   Unverferth, Klaus ^b   Pihlaja, Kalevi ^c   Wiinamäki, Kirsti ^c   Sinkkonen, Jari ^c   Kijkowska Murak, Urszula ^a   Wróbel, Tomasz ^a   Stacha, Tomasz ^a   Matosiuk, Dariusz ^a  

^a MEDICAL UNIVERSITY OF LUBLIN   (Poland)

^b Biotie Therapie GmbH   (Germany)

^c UNIVERSITY OF TURKU   (Finland)

Author keywords

Allosteric modulators; Glutamate receptors; Indole derivatives; Kainate receptors; Molecular modelling, Non competitive antagonists of kainate receptors

Indexed keywords

1 [(4 CHLOROPHENYL)METHYL] 5 METHOXY 2 (4 METHOXYPHENYL) 3 METHYLINDOLE; 1 ETHYL 2 (4 METHOXYPHENYL) 3 METHYLINDOLE; 1 ETHYL 2 PHENYL 5 METHOXY 3 METHYLINDOLE; 1 ETHYL 5 METHOXY 2 (4 METHOXYPHENYL) 3 METHYLINDOLE; 1 ETHYL 5 METHOXY 2 PHENYLINDOLE; 11 ETHYL 8 METHOXY 6,11 DIHYDRO 5H BENZO[A]CARBAZOLE; 5 METHOXY 2 (4 METHOXYPHENYL) 3 METHYLINDOLE; CALCIUM ION; GLUK1 RECEPTOR; GLUK2 RECEPTOR; GLUTAMATE RECEPTOR; INDOLE DERIVATIVE; ION CHANNEL; KAINIC ACID; KAINIC ACID RECEPTOR; KAINIC ACID RECEPTOR ANTAGONIST; UNCLASSIFIED DRUG;

AB INITIO CALCULATION; ALKYLATION; ALLOSTERISM; ARTICLE; BINDING SITE; CELL STRAIN HEK293; DIPOLE; DRUG SYNTHESIS; HYDROGEN BOND; IC 50; MOLECULAR DOCKING; MOLECULAR MODEL; PHARMACOPHORE; PRIORITY JOURNAL;

EID: 84870419172     PISSN: 15701808     EISSN: 1875628X     Source Type: Journal    
DOI: 10.2174/157018012804586978     Document Type: Article

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