Sulfamoyloxy-substituted 2-phenylindoles: Antiestrogen-based inhibitors of the steroid sulfatase in human breast cancer cells

Bioorganic and Medicinal Chemistry

Volumn 10, Issue 12, 2002, Pages 3941-3953

  Golob, Thomas ^a   Liebl, Renate ^a   Von Angerer, Erwin ^a  

^a UNIVERSITY OF REGENSBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

1 ETHYL 2 (4 HYDROXYPHENYL) 3 METHYL 5 SULFAMOYLOXYINDOLE; 1 ETHYL 2 (4 HYDROXYPHENYL) 3 METHYL 6 SULFAMOYLOXYINDOLE; 1 ETHYL 2 (4 HYDROXYPHENYL) 3 METHYLINDOLE; 1 ETHYL 3 METHYL 2 (4 SULFAMOYLOXYPHENYL)INDOLE; 1 ETHYL 3 METHYL 2 PHENYL 6 SULFAMOYLOXYINDOLE; 1 ETHYL 3 METHYL 5 SULFAMOYLOXY 2 (4 SULFAMOYLOXYPHENYL)INDOLE; 1 ETHYL 3 METHYL 6 SULFAMOYLOXY 2 (4 SULFAMOYLPHENYL)INDOLE; 1 ETHYL 5 HYDROXY 3 METHYL 2 PHENYLINDOLE; 1 ETHYL 6 HYDROXY 3 METHYL 2 PHENYLINDOLE; 2 (4 HYDROXYPHENYL) 3 METHYL 1 [10 (PENTYLSULFONYL)DECYL]INDOLE; 2 (4 HYDROXYPHENYL) 5 METHOXYCARBONYL 3 METHYL 1 [10 (PENTYLSULFONYL)DECYL]INDOLE; 3 METHYL 1 (5 PYRROLIDINOCARBONYLPENTYL) 5 SULFAMOYLOXY 2 (4 SULFAMOYLOXYPHENYL)INDOLE; 3 METHYL 1 (5 PYRROLIDINOCARBONYLPENTYL) 6 SULFAMOYLOXY 2 (4 SULFAMOYLOXYPHENYL)INDOLE; 3 METHYL 1 [10 (PENTYLSULFONYL)DECYL] 5 SULFAMOYLOXY 2 (4 SULFAMOYLOXYPHENYL)INDOLE; 3 METHYL 1 [10 (PENTYLSULFONYL)DECYL] 6 SULFAMOYLOXY 2 (4 SULFAMOYLOXYPHENYL)INDOLE; 5 CARBAMOYL 2 (4 HYDROXYPHENYL) 3 METHYL 1 [10 (PENTYLSULFONYL)DECYL]INDOLE; 5 CYANO 3 METHYL 1 [10 (PENTYLSULFONYL)DECYL] 2 (4 SULFAMOYLOXYPHENYL)INDOLE; 5 METHYL 1 (6 PYRROLIDINOHEXYL) 5 SULFAMOYLOXY 2 (4 SULFAMOYLOXYPHENYL)INDOLE; 6 HYDROXY 2 (4 HYDROXYPHENYL) 3 METHYL 1 (5 PYRROLIDINOCARBONYLPENTYL)INDOLE; 6 HYDROXY 2 (4 HYDROXYPHENYL) 3 METHYL 1 (6 PYRROLIDINOHEXYL)INDOLE; 6 HYDROXY 2 (4 HYDROXYPHENYL) METHYL 1 [10 (PENTYLSULFONYL)DECYL]INDOLE; ANTINEOPLASTIC AGENT; ENZYME INHIBITOR; ESTROGEN; HYDROXYL GROUP; LUCIFERASE; METHYL 1 (6 PYRROLIDINOHEXYL) 6 SULFAMOYLOXY 2 (4 SULFAMOYLOXYPHENYL)INDOLE; STERYL SULFATASE; UNCLASSIFIED DRUG; UNINDEXED DRUG; ZK 119010; ZK 164015;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CANCER; BREAST CARCINOMA; CANCER CELL; CANCER GROWTH; CARCINOMA CELL; CONTROLLED STUDY; DRUG ACTIVITY; DRUG SCREENING; DRUG SYNTHESIS; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; GENE EXPRESSION; GENE REPRESSION; GENETIC TRANSFECTION; GROWTH INHIBITION; HUMAN; HUMAN CELL; HYDROLYSIS; IC 50; NONHUMAN; PRECURSOR;

ARYLSULFATASES; BREAST NEOPLASMS; ESTROGEN RECEPTOR MODULATORS; FEMALE; HUMANS; INDOLES; INHIBITORY CONCENTRATION 50; NEOPLASM PROTEINS; RADIOLIGAND ASSAY; STERYL-SULFATASE; STRUCTURE-ACTIVITY RELATIONSHIP; SULFATASES; SULFONIC ACIDS; TUMOR CELLS, CULTURED;

MINK CELL FOCUS-FORMING VIRUS;

EID: 0036979174     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(02)00306-1     Document Type: Article

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