Bioisosteric modifications of 2-arylureidobenzoic acids: Selective noncompetitive antagonists for the homomeric kainate receptor subtype GluR5

Journal of Medicinal Chemistry

Volumn 47, Issue 27, 2004, Pages 6948-6957

  Valgeirsson, Jon ^a,c   Nielsen, Elsebet Ø ^a   Peters, Dan ^a   Mathiesen, Claus ^a   Kristensen, Anders S ^b   Madsen, Ulf ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b NEUROSEARCH A S   (Denmark)

^c Actavis ^*  (Iceland)

Author keywords

[No Author keywords available]

Indexed keywords

1 (3 BROMOPHENYL) 3 [5 CHLORO 2(1H) TETRAZOL 5 YLPHENYL]UREA; 2 [3 (3 BROMOPHENYL)UREIDO] 4 CHLOROBENZENESULFONIC ACID; ALPHA AMINO 5 TERT BUTYL 3 HYDROXY 4 ISOXAZOLEPROPIONIC ACID; GLUTAMATE RECEPTOR; GLUTAMATE RECEPTOR 5; GLUTAMATE RECEPTOR AGONIST; GLUTAMATE RECEPTOR ANTAGONIST; KAINIC ACID RECEPTOR; RECEPTOR SUBTYPE; TRITIUM; UNCLASSIFIED DRUG; UREIDOBENZOIC ACID DERIVATIVE;

ANIMAL MODEL; ARTICLE; CENTRAL NERVOUS SYSTEM; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; FEMALE; HUMAN; HUMAN CELL; MOUSE; MUSCLE RIGIDITY; NEUROPHARMACOLOGY; NEUROTRANSMISSION; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ANIMALS; BENZOIC ACIDS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HUMANS; MICE; RATS; RECEPTORS, KAINIC ACID; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 11244334171     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm030638w     Document Type: Article

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