An improved racemase/acylase biotransformation for the preparation of enantiomerically pure amino acids

Journal of the American Chemical Society

Volumn 134, Issue 47, 2012, Pages 19310-19313

  Baxter, Scott ^a,e   Royer, Sylvain ^b,f   Grogan, Gideon ^c   Brown, Fraser ^e   Holt Tiffin, Karen E ^d   Taylor, Ian N ^d   Fotheringham, Ian G ^e   Campopiano, Dominic J ^a,e  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b University of Bath   (United Kingdom)

^c UNIVERSITY OF YORK   (United Kingdom)

^d Chirotech Technology Centre   (United Kingdom)

^e Ingenza Ltd   (United Kingdom)

^f UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYTIC PERFORMANCE; DIRECTED EVOLUTION; DYNAMIC KINETIC RESOLUTION; ENANTIOSPECIFIC; HIGH SUBSTRATE CONCENTRATIONS; INDUSTRIAL SCALE; RACEMASE; SIDE-CHAINS; WILD TYPES; WILD-TYPE ENZYMES; X-RAY CRYSTAL ANALYSIS;

ENANTIOMERS;

AMINO ACIDS;

ALLYLGLYCINE; ALPHA AMINO ACID; AMIDASE; AMINO ACID; N ACETYL AMINO ACID RACEMASE; RACEMASE; UNCLASSIFIED DRUG;

ARTICLE; BIOTRANSFORMATION; CHEMICAL ANALYSIS; CHEMICAL INTERACTION; ENANTIOMER; ENZYME ACTIVITY; ENZYME KINETICS; KINETIC RESOLUTION; RACEMIZATION; WILD TYPE; X RAY CRYSTALLOGRAPHY;

AMIDOHYDROLASES; AMINO ACIDS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; RACEMASES AND EPIMERASES; STEREOISOMERISM;

EID: 84870387628     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja305438y     Document Type: Article

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