Dynamic kinetic resolution

Current Opinion in Chemical Biology

Volumn 3, Issue 1, 1999, Pages 11-15

  El Gihani, Moharem T ^a   Williams, Jonathan M J ^a  

^a University of Bath Claverton Down   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; ENZYME; MANDELATE RACEMASE; METAL;

DRUG PURIFICATION; ENANTIOMER; ENZYME KINETICS; METHODOLOGY; RACEMIC MIXTURE; SHORT SURVEY;

EID: 0033023975     PISSN: 13675931     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1367-5931(99)80003-9     Document Type: Article

References (19)

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3. Ward RS Dynamic kinetic resolution. Tetrahedron - Asymmetry. 6:1995;1475-1490.
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5. Ebbers EJ, Ariaans GJA, Houbiers JPM, Bruggink A, Zwanenburg B Controlled racemisation of optically active organic compounds: prospects for asymmetric transformation. Tetrahedron. 53:1997;9417-9476. This is an excellent account of racemisation protocols.
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10. Stürmer R Enzymes and transition metal complexes in tandem-a new concept for dynamic kinetic resolution. Angew Chem Int Ed Engl. 36:1997;1173-1174. This paper highlights the tandem use of transition metals as a new concept in dynamic kinetic resolution.
11. Reetz MT, Schimossek K Lipase-catalysed dynamic kinetic resolution of chiral amines: use of palladium as the racemization catalyst. Chimica. 50:1996;668-669.
12. Allen JV, Williams JMJ Dynamic kinetic resolution with enzyme and palladium combinations. Tetrahedron Lett. 37:1996;1859-1862.
13. Dinh PM, Howarth JA, Hudnott AR, Williams JMJ, Harris W Catalytic racemisation of alcohols: applications to enzymatic resolution reactions. Tetrahedron Lett. 37:1996;7623-7626.
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15. Turner NJ, Winterman JR, McCague R, Parratt JS, Taylor JC Synthesis of homochiral L-(S)-tert-leucine via a lipase catalysed dynamic resolution process. Tetrahedron Lett. 36:1995;1113-1116.
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17. Um P-J, Drueckhammer DG Dynamic enzymatic resolution of thioesters. J Am Chem SoC. 120:1998;5605-5610. This is an excellent comprehensive study.
18. Garcia MJ, Azerad R Production of ring-substituted D-phenylglycines by Microbial or enzymatic hydroysis/deracemisation of the corresponding DL-hydantoins. Tetrahedron - Asymmetry. 8:1997;85-92. This paper demonstrates the use of dynamic kinetic resolution in the synthesis of desirable synthons.
19. Stecher H, Felfer U, Faber K Large-scale production of Mandelate racemase by Pseudomonas putida ATCC 12633: optimization of enzyme induction and development of a stable crude enzyme preparation. J Biotechnol. 56:1997;33-40. This paper highlights the use of enzymes as racemising agents.