Inactivation of encapsulated cells and their therapeutic effects by means of TGL triple-fusion reporter/biosafety gene

Biomaterials

Volumn 34, Issue 4, 2013, Pages 1442-1451

  Santos, Edorta ^a,b   Larzabal, Leyre ^c   Calvo, Alfonso ^c   Orive, Gorka ^a,b   Pedraz, José Luis ^a,b   Hernández, Rosa Ma ^a,b  

^a UNIVERSITY OF THE BASQUE COUNTRY UPV EHU   (Spain)

^b BIOMATERIALES Y NANOMEDICINA CIBER BBN   (Spain)

^c UNIVERSITY OF NAVARRA   (Spain)

Author keywords

Biosafety; Drug delivery; HSV TK; Microcapsule; TGL

Indexed keywords

BIOSAFETY; ENCAPSULATED CELL; ERYTHROPOIETIN (EPO); FIREFLY LUCIFERASE; GANCICLOVIR; GREEN FLUORESCENT PROTEIN; HERPES SIMPLEX VIRUS TYPE 1; HSV-TK; IN-VITRO; IN-VIVO; INACTIVATION PROCESS; MICROCAPSULES; MYOBLASTS; REPORTER GENE; TECHNOLOGY DESIGNS; TGL; THERAPEUTIC EFFECTS; THERAPEUTIC PRODUCTS;

CYTOLOGY; DRUG DELIVERY; ENCAPSULATION; GENE THERAPY; GENETIC ENGINEERING; PRODUCT DESIGN; TWO DIMENSIONAL; VIRUSES;

CELLS;

ERYTHROPOIETIN; FIREFLY LUCIFERASE; GANCICLOVIR; GREEN FLUORESCENT PROTEIN; HERPES SIMPLEX VIRUS TYPE 1 THYMIDINE KINASE; THYMIDINE KINASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BIOSAFETY; BIOSAFETY GENE; CELL ENCAPSULATION; CONTROLLED STUDY; DRUG SENSITIVITY; FEMALE; HEMATOCRIT; MOUSE; MYOBLAST; NONHUMAN; PLASMID; PRIORITY JOURNAL; REPORTER GENE; THERAPY EFFECT; TRIPLE FUSION REPORTER GENE;

ANIMALS; CELL LINE; CELL SURVIVAL; GANCICLOVIR; GENES, REPORTER; GREEN FLUORESCENT PROTEINS; HERPESVIRUS 1, HUMAN; LUCIFERASES, FIREFLY; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED C3H; MYOBLASTS; RECOMBINANT FUSION PROTEINS; THYMIDINE KINASE; TREATMENT OUTCOME;

HUMAN HERPESVIRUS 1; MUS; SIMPLEXVIRUS;

EID: 84870371579     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2012.10.076     Document Type: Article

References (42)

1. Hernández R.M., Orive G., Murua A., Pedraz J.L. Microcapsules and microcarriers for in situ cell delivery. Adv Drug Deliv Rev 2010, 62:711-730.
2. Calafiore R., Basta G., Luca G., Lemmi A., Montanucci M.P., Calabrese G., et al. Microencapsulated pancreatic islet allografts into nonimmunosuppressed patients with type 1 diabetes: first two cases. Diabetes Care 2006, 29:137-138.
3. Sieving P.A., Caruso R.C., Tao W., Coleman H.R., Thompson D.J., Fullmer K.R., et al. Ciliary neurotrophic factor (CNTF) for human retinal degeneration: phase I trial of CNTF delivered by encapsulated cell intraocular implants. Proc Natl Acad Sci U S A 2006, 103:3896-3901.
4. Bloch J., Bachoud-Levi A.C., Deglon N., Lefaucheur J.P., Winkel L., Palfi S., et al. Neuroprotective gene therapy for Huntington's disease, using polymer-encapsulated cells engineered to secrete human ciliary neurotrophic factor: results of a phase I study. Hum Gene Ther 2004, 15:968-975.
5. Salmons B., Lohr M., Gunzburg W.H. Treatment of inoperable pancreatic carcinoma using a cell-based local chemotherapy: results of a phase I/II clinical trial. J Gastroenterol 2003, 38(Suppl. 15):78-84.
6. Lohr M., Hoffmeyer A., Kroger J., Freund M., Hain J., Holle A., et al. Microencapsulated cell-mediated treatment of inoperable pancreatic carcinoma. Lancet 2001, 357:1591-1592.
7. Aebischer P., Schluep M., Deglon N., Joseph J.M., Hirt L., Heyd B., et al. Intrathecal delivery of CNTF using encapsulated genetically modified xenogeneic cells in amyotrophic lateral sclerosis patients. Nat Med 1996, 2:696-699.
8. Goren A., Dahan N., Goren E., Baruch L., Machluf M. Encapsulated human mesenchymal stem cells: a unique hypoimmunogenic platform for long-term cellular therapy. FASEB J 2010, 24:22-31.
9. Gautier A., Carpentier B., Dufresne M., Vu Dinh Q., Paullier P., Legallais C. Impact of alginate type and bead diameter on mass transfers and the metabolic activities of encapsulated C3A cells in bioartificial liver applications. Eur Cell Mater 2011, 21:94-106.
10. Veriter S., Aouassar N., Adnet P.Y., Paridaens M.S., Stuckman C., Jordan B., et al. The impact of hyperglycemia and the presence of encapsulated islets on oxygenation within a bioartificial pancreas in the presence of mesenchymal stem cells in a diabetic Wistar rat model. Biomaterials 2011, 32:5945-5956.
11. de Vos P., Bucko M., Gemeiner P., Navratil M., Svitel J., Faas M., et al. Multiscale requirements for bioencapsulation in medicine and biotechnology. Biomaterials 2009, 30:2559-2570.
12. Kim K., Liu X., Zhang Y., Cheng J., Yu Wu X., Sun Y. Elastic and viscoelastic characterization of microcapsules for drug delivery using a force-feedback MEMS microgripper. Biomed Microdevices 2009, 11:421-427.
13. Leung A., Trau M., Nielsen L.K. Assembly of multilayer PSS/PAH membrane on coherent alginate/PLO microcapsule for long-term graft transplantation. J Biomed Mater Res A 2009, 88:226-237.
14. Williams D.F. On the mechanisms of biocompatibility. Biomaterials 2008, 29:2941-2953.
15. Tam S.K., Dusseault J., Bilodeau S., Langlois G., Halle J.P., Yahia L. Factors influencing alginate gel biocompatibility. J Biomed Mater Res A 2011, 98:40-52.
16. Tam S.K., Bilodeau S., Dusseault J., Langlois G., Halle J.P., Yahia L.H. Biocompatibility and physicochemical characteristics of alginate-polycation microcapsules. Acta Biomater 2011, 7:1683-1692.
17. Baruch L., Benny O., Gilert A., Ukobnik M., Ben Itzhak O., Machluf M. Alginate-PLL cell encapsulation system co-entrapping PLGA-microspheres for the continuous release of anti-inflammatory drugs. Biomed Microdevices 2009, 11:1103-1113.
18. Orive G., De Castro M., Kong H.J., Hernandez R.M., Ponce S., Mooney D.J., et al. Bioactive cell-hydrogel microcapsules for cell-based drug delivery. J Control Release 2009, 135:203-210.
19. Santos E., Orive G., Calvo A., Catena R., Fernández-Robredo P., Layana A.G., et al. Optimization of 100 μm alginate-poly-l-lysine-alginate capsules for intravitreous administration. J Control Release 2012, 158:443-450.
20. Sakai S., Hashimoto I., Tanaka S., Salmons B., Kawakami K. Small agarose microcapsules with cell-enclosing hollow core for cell therapy: transplantation of ifosfamide-activating cells to the mice with preestablished subcutaneous tumor. Cell Transplant 2009, 18:933-939.
21. Murua A., Orive G., Hernandez R.M., Pedraz J.L. Xenogeneic transplantation of erythropoietin-secreting cells immobilized in microcapsules using transient immunosuppression. J Control Release 2009, 137:174-178.
22. Sgroi A., Mai G., Morel P., Baertschiger R.M., Gonelle-Gispert C., Serre-Beinier V., et al. Transplantation of encapsulated hepatocytes during acute liver failure improves survival without stimulating native liver regeneration. Cell Transplant 2011, 20:1791-1803.
23. Zhang H., Zhu S.J., Wang W., Wei Y.J., Hu S.S. Transplantation of microencapsulated genetically modified xenogeneic cells augments angiogenesis and improves heart function. Gene Ther 2008, 15:40-48.
24. Vaithilingam V., Quayum N., Joglekar M.V., Jensen J., Hardikar A.A., Oberholzer J., et al. Effect of alginate encapsulation on the cellular transcriptome of human islets. Biomaterials 2011, 32:8416-8425.
25. Montanucci P., Pennoni I., Pescara T., Blasi P., Bistoni G., Basta G., et al. The functional performance of microencapsulated human pancreatic islet-derived precursor cells. Biomaterials 2011, 32:9254-9262.
26. Catena R., Santos E., Orive G., Hernández R.M., Pedraz J.L., Calvo A. Improvement of the monitoring and biosafety of encapsulated cells using the SFGNESTGL triple reporter system. J Control Release 2010, 146:93-98.
27. Deglon N., Heyd B., Tan S.A., Joseph J.M., Zurn A.D., Aebischer P. Central nervous system delivery of recombinant ciliary neurotrophic factor by polymer encapsulated differentiated C2C12 myoblasts. Hum Gene Ther 1996, 7:2135-2146.
28. Tomicic M.T., Thust R., Kaina B. Ganciclovir-induced apoptosis in HSV-1 thymidine kinase expressing cells: critical role of DNA breaks, Bcl-2 decline and caspase-9 activation. Oncogene 2002, 21:2141-2153.
29. Mullen C.A. Metabolic suicide genes in gene therapy. Pharmacol Ther 1994, 63:199-207.
30. Santos E., Hernandez R.M., Pedraz J.L., Orive G. Novel advances in the design of three-dimensional bio-scaffolds to control cell fate: translation from 2D to 3D. Trends Biotechnol 2012, 30:331-341.
31. Chateauvieux S., Grigorakaki C., Morceau F., Dicato M., Diederich M. Erythropoietin, erythropoiesis and beyond. Biochem Pharmacol 2011, 82:1291-1303.
32. Zhu J., Emerson S.G. Hematopoietic cytokines, transcription factors and lineage commitment. Oncogene 2002, 21:3295-3313.
33. Kariko K., Muramatsu H., Keller J.M., Weissman D. Increased erythropoiesis in mice injected with submicrogram quantities of pseudouridine-containing mRNA encoding erythropoietin. Mol Ther 2012, 20:948-953.
34. Ponomarev V., Doubrovin M., Serganova I., Vider J., Shavrin A., Beresten T., et al. A novel triple-modality reporter gene for whole-body fluorescent, bioluminescent, and nuclear noninvasive imaging. Eur J Nucl Med Mol Imaging 2004, 31:740-751.
35. Lim F., Sun A. Microencapsulated islets as bioartificial endocrine pancreas. Science 1980, 210:908-910.
36. Aebischer P., Pochon N.A., Heyd B., Deglon N., Joseph J.M., Zurn A.D., et al. Gene therapy for amyotrophic lateral sclerosis (ALS) using a polymer encapsulated xenogenic cell line engineered to secrete hCNTF. Hum Gene Ther 1996, 7:851-860.
37. Leung A., Nielsen L.K., Trau M., Timmins N.E. Tissue transplantation by stealth-coherent alginate microcapsules for immunoisolation. Biochem Eng J 2010, 48:337-347.
38. Hill E., Boontheekul T., Mooney D.J. Designing scaffolds to enhance transplanted myoblast survival and migration. Tissue Eng 2006, 12:1295-1304.
39. Thakur A., Sengupta R., Matsui H., Lillicrap D., Jones K., Hortelano G. Characterization of viability and proliferation of alginate-poly-L-lysine-alginate encapsulated myoblasts using flow cytometry. J Biomed Mater Res B Appl Biomater 2010, 94:296-304.
40. Provencher Bolliger A., Everds E.N., Zimmerman L.K., Moore M.D., Smith A.S., Barnhart F.K. Hematology of laboratory animals. Schalm's veterinary hematology 2010, 852-887. John Wiley & Sons Inc. 6th ed. D. Weiss, K.J. Wardrop (Eds.).
41. Duan J., Paris W., Kibler P., Bousquet C., Liuzzi M., Cordingley M.G. Dose and duration-dependence of ganciclovir treatment against murine cytomegalovirus infection in severe combined immunodeficient mice. Antiviral Res 1998, 39:189-197.
42. Kauer T.M., Figueiredo J.L., Hingtgen S., Shah K. Encapsulated therapeutic stem cells implanted in the tumor resection cavity induce cell death in gliomas. Nat Neurosci 2011, 15:197-204.