Impact of alginate type and bead diameter on mass transfers and the metabolic activities of encapsulated c3a cells in bioartificial liver applications

European Cells and Materials

Volumn 21, Issue , 2011, Pages 94-106

  Gautier, A ^a   Carpentier, B ^a   Dufresne, M ^a   Vu Dinh, Q ^a   Paullier, P ^a   Legallais, C ^a  

^a UNIVERSITÉ DE TECHNOLOGIE DE COMPIÈGNE   (France)

Author keywords

Alginate; Encapsulation; Hepatocyte; Liver; Tissue engineering

Indexed keywords

ALBUMIN; ALGINIC ACID; ALPHA FETOPROTEIN; AMMONIA; GLUCOSE;

ARTICLE; BIOARTIFICIAL LIVER; BIOREACTOR; CELL ENCAPSULATION; CELL METABOLISM; CELL VIABILITY; CONTROLLED STUDY; DIFFUSION; HUMAN; HUMAN CELL; LIVER CELL; LIVER CELL CULTURE; PARTICLE SIZE; PROCESS OPTIMIZATION; VISCOSITY;

EID: 79551548104     PISSN: 14732262     EISSN: None     Source Type: Journal    
DOI: 10.22203/eCM.v021a08     Document Type: Article

References (44)

1. 2+ ions. Reactive and Functional Polymers 59: 129-140.
2. Bazou D, Coakley WT, Hayes AJ, Jackson SK (2008) Long-term viability and proliferation of alginateencapsulated 3-D HepG2 aggregates formed in an ultrasound trap. Tox In Vitro 22: 1321-1331.
3. Berthiaume F, Moghe PV, Toner M, Yarmush ML (1996) Effect of extracellular matrix topology on cell structure, function, and physiological responsiveness: hepatocytes cultured in a sandwich configuration. FASEB J 10: 1471-1484.
4. Canaple L, Nurdin N, Angelova N, Saugy D, Hunkeler D, Desvergne B (2001) Maintenance of primary murine hepatocyte functions in multi component polymer capsules - in vitro cryopreservation studies. J Hepatol 34: 11-18.
5. Carpentier B, Gautier A, Legallais C (2009) Artificial and bioartificial liver devices: present and future. Gut 58: 1690-1702.
6. Chang TM (2005) Therapeutic applications of polymeric artificial cells. Nat Rev Drug Discov 4: 221-235.
7. Clement B, Desille M, Fremond B, Campion JP, Guguen-Guillouzo C, Bourel M (1998) Hepatocytes en therapie cellulaire [Hepatocytes in cell therapy]. Transfus Clin Biol 5: 80-87.
8. Coward SM, Selden C, Mantalaris A, Hodgson HJ (2005) Proliferation rates of HepG2 cells encapsulated in alginate are increased in a microgravity environment compared with static cultures. Artif Organs 29: 152-158.
9. David B, Barbe L, Barthes-Biesel D, Legallais C (2006) Mechanical properties of alginate beads hosting hepatocytes in a fluidized bed bioreactor. Int J Artif Organs 29: 756-763.
10. David B, Doré E, Jaffrin MY, Legallais C (2004) Mass transfer in a fluidized bed bioreactor using alginate beads for a future bioartificial liver. Int J Artif Organs 27: 284-293.
11. David B, Dufresne M, Nagel MD, Legallais C (2004) In vitro assessment of encapsulated C3A hepatocytes functions in a fluidised bed bioreactor. Biotechnol Prog 20: 1204-1212.
12. De Bartolo L, Morelli S, Lopez LC, Giorno L, Campana C, Salerno S, Rende M, Favia P, Detomaso L, Gristina R, Agostino R, Drioli E (2005) Biotransformation and liverspecific functions of human hepatocytes in culture on RGD-immobilized plasma-processed membranes. Biomaterials 26: 4432-4441.
13. De Vos P, Faas MM, Strand B, Calafiore R (2006) Alginate-based microcapsules for immunoisolation of pancreatic islets. Biomaterials 27: 5603-5617.
14. Dore E, Legallais C (1999) A new concept of bioartificial liver based on a fluidized bed bioreactor. Ther Apher 3: 264-267.
15. Elaut G, Vanhaecke T, Heyden YV, Rogiers V (2005) Spontaneous apoptosis, necrosis, energy status, glutathione levels and biotransformation capacities of isolated rat hepatocytes in suspension: effect of the incubation medium. Biochem Pharmacol 69: 1829-1838.
16. Figliuzzi M, Plati T, Cornolti R, Adobati F, Fagiani A, Rossi L, Remuzzi G, Remuzzi A (2006) Biocompatibility and function of microencapsulated pancreatic islets. Acta Biomater 2: 221-227.
17. Fremond B, Joly A, Desille M, Desjardins JF, Campion JP, Clement B (1996) Cell-based therapy of acute liver failure: the extracorporeal bioartificial liver. Cell Biol Toxicol 12: 325-329.
18. Gao Y, Jiang HC, Xu J, Pan SH, Li YD (2005) Microencapsulating hepatocytes. Transplant Proc 37: 4589-4593.
19. Garbayo I, Leon R, Vilchez C (2002) Diffusion characteristics of nitrate and glycerol in alginate. Colloids Surf B 25: 1-9.
20. Haque T, Chen H, Ouyang W, Martoni C, Lawuyi B, Urbanska A, Prakash S (2005) Investigation of a new microcapsule membrane combining alginate, chitosan, polyethylene glycol, poly-L-lysine for cell ransplantation applications. Int J Artif Organs 28: 631-637.
21. Jiankang H, Dichen L, Yaxiong L, Bo Y, Hanxiang Z, Qin L, Bingheng L, Yi L (2009) Preparation of chitosangelatin hybrid scaffolds with well-organized microstructures for hepatic tissue engineering. Acta Biomater 5: 453-461.
22. Khalil M, Shariat-Panahi A, Tootle R, Ryder T, McCloskey P, Roberts E, Hodgson H, Selden C (2001) Human hepatocyte cell lines proliferating as cohesive spheroid colonies in alginate markedly upregulate both synthetic and detoxificatory liver function. J Hepatol 34: 68-77.
23. Kinasiewicz A, Gautier A, Lewinska D, Bukowski J, Legallais C, Werynski A (2007) Culture of C3A cells in alginate beads for fluidized bed bioartificial liver. Transplant Proc 39: 2911-2913.
24. Kinasiewicz A, Gautier A, Lewinska D, Smietanka A, Legallais C, Werynski A (2008) Three-dimensional growth of human hepatoma C3A cells within alginate beads for fluidized bioartificial liver. Int J Artif Organs 31: 340-347.
25. Legallais C, Dore E, Paullier P (2000) Design of a fluidized bed bioartificial liver. Artif Organs 24: 519-525.
26. Legallais C, David B, Dore E (2001) Bioartificial livers (BAL): currrent technological aspects and future developments. J Membr Sci 181: 81-95.
27. Legallais C, Gautier A, Dufresne M, Carpentier B, Baudoin R (2008) The place of adsorption and biochromatography in extracorporeal liver support systems. J Chromatogr B 861: 171-176.
28. Lewinska D, Rosinski S, Hunkeler D, Poncelet D, Werynski A (2002) Mass transfer coefficient in characterization of gel beads and microcapsules. J Membr Sci 209: 533-540.
29. Martinsen A, Skjak-Braek G, Smidsrod O (1989) Alginate as immobilization material: I. Correlation between chemical and physical properties of alginate gel beads. Biotechnol Bioeng 33: 79-89.
30. Mukwena NT, Al-Rubeai M (2004) Apoptosis and its suppression in hepatocytes culture. Cytotechnology 46: 79-95.
31. Orive G, Hernandez RM, Rodriguez Gascon A, Calafiore R, Chang TM, De Vos P, Hortelano G, Hunkeler D, Lack I, Pedraz JL (2004) History, challenges and perspectives of cell microencapsulation. Trends Biotechnol 22: 87-92.
32. Orive G, Tam SK, Pedraz JL, Halle JP (2006) Biocompatibility of alginate-poly-l-lysine microcapsules for cell therapy. Biomaterials 27: 3691-3700.
33. Paul A, Ge Y, Prakash S, Shum-Tim D (2009) Microencapsulated stem cells for tissue repairing: implications in cell-based myocardial therapy. Regen Med 4: 733-745.
34. Selden C, Shariat A, McCloskey P, Ryder T, Roberts E, Hodgson H (1999) Three-dimensional in vitro cell culture leads to a marked upregulation of cell function in human hepatocyte cell lines-an important tool for the development of a bioartificial liver machine. Ann NY Acad Sci 875: 353-863.
35. Seo SJ, Kim IY, Choi YJ, Akaike T, Cho CS (2006) Enhanced liver functions of hepatocytes cocultured with NIH 3T3 in the alginate/galactosylated chitosan scaffold. Biomaterials 27: 1487-1495.
36. Tsai WB, Lin JH (2009) Modulation of morphology and functions of human hepatobastoma cells by nanogrooved substrata. Acta Biomater 5: 1442-1454.
37. Tuschl G, Hrach J, Walter Y, Hewitt PG, Mueller SO (2009) Serum-free collagen sandwich cultures of adult rat hepatocytes maintain liver-like properties long term: a valuable model for in vitro toxicity and drug-drug interaction studies. Chem Biol Interact 181: 124-137.
38. Ueyama Y, Ishikawa K, Mano T, Koyama T, Nagatsuka H, Suzuki K, Ryoke K (2002) Usefulness as guided bone regeneration membrane of the alginate membrane. Biomaterials 23: 2027-2033.
39. Vollmar B, Menger MD (2009) The hepatic microcirculation: mechanistic contributions and therapeutic targets in liver injury and repair. Physiol Rev 89: 1269-339.
40. Wang N, Adams G, Buttery L, Falcone FH, Stolnik S (2009) Alginate encapsulation technology supports embryonic stem cells differentiation into insulin-producing cells. J Biotechnol 144: 304-312.
41. Wikstrom J, Elomaa M, Syvajarvi H, Kuokkanen J, Yliperttula M, Honkakoski P, Urtti A (2008) Alginatebased microencapsulation of retinal pigment epithelial cell line for cell therapy. Biomaterials 29: 869-876.
42. Yang J, Goto M, Ise H, Cho CS, Akaike T (2002) Galactosylated alginate as a scaffold for hepatocytes entrapment. Biomaterials 23: 471-479.
43. Zimmermann H, Wehlisch F, Baier C, Westhoff M, Reuss R, Zimmermann D, Behringer M, Ehrhart F, Katsen- Globa A, Giese C, Marx U, Sukhorukov VL, Vasquez JA, Jakob P, Shirley SG, Zimmermann U (2007) Physical and biological properties of barium cross-linked alginate membranes. Biomaterials 28: 1327-1345.
44. Zmora S, Glicklis R, Cohen S (2002) Tailoring the pore architecture in 3-D alginate scaffolds by controlling the freezing regime during fabrication. Biomaterials 23: 4087-4094.