Identification of key residues essential for the structural fold and receptor selectivity within the A-chain of human gene-2 (H2) relaxin

Journal of Biological Chemistry

Volumn 287, Issue 49, 2012, Pages 41152-41164

  Chan, Linda J ^a   Rosengren, K Johan ^b   Layfield, Sharon L ^a   Bathgate, Ross A D ^a   Separovic, Frances ^a   Samuel, Chrishan S ^a,c   Hossain, Mohammed A ^a   Wade, John D ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b UNIVERSITY OF QUEENSLAND   (Australia)

^c MONASH UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION MECHANISMS; BINDING MECHANISMS; CLINICAL TRIAL; COLLAGEN DEPOSITION; CROSS-REACTIVITY; DISULFIDE BONDS; HEART FAILURE; IN-PHASE; IN-VITRO; KEY RESIDUES; LEUCINE-RICH REPEATS; SECONDARY INTERACTIONS; TRANSMEMBRANES; TWO CHAINS;

AMINO ACIDS; COVALENT BONDS; GENES; INSULIN;

PEPTIDES;

COLLAGEN; G PROTEIN COUPLED RECEPTOR; MEMBRANE PROTEIN; RELAXIN; RELAXIN FAMILY PEPTIDE RECEPTOR 1; RELAXIN FAMILY PEPTIDE RECEPTOR 2; UNCLASSIFIED DRUG;

ALPHA CHAIN; AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG CROSS REACTIVITY; DRUG RECEPTOR BINDING; EMBRYO; GENE MUTATION; HEART MUSCLE FIBROSIS; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DETERMINATION; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN METABOLISM;

ALANINE; CIRCULAR DICHROISM; CYCLIC AMP; FIBROSIS; HEK293 CELLS; HUMANS; LIGANDS; MAGNETIC RESONANCE SPECTROSCOPY; PEPTIDE HORMONES; PEPTIDES; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, G-PROTEIN-COUPLED; RELAXIN;

EID: 84870365074     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.409284     Document Type: Article

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