메뉴 건너뛰기




Volumn 151, Issue 10, 2010, Pages 4938-4948

Antifibrotic properties of relaxin: In vivo mechanism of action in experimental renal tubulointerstitial fibrosis

Author keywords

[No Author keywords available]

Indexed keywords

ANTIFIBROTIC AGENT; COLLAGEN TYPE 1; COLLAGEN TYPE 4; GELATINASE B; RELAXIN; SMAD2 PROTEIN; TRANSFORMING GROWTH FACTOR BETA2; VASCULOTROPIN; COLLAGEN; GELATINASE; RLN2 PROTEIN, HUMAN;

EID: 77957281721     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2010-0286     Document Type: Article
Times cited : (62)

References (42)
  • 1
    • 67349203391 scopus 로고    scopus 로고
    • Ureteral obstruction as a model of renal interstitial fibrosis and obstructive nephropathy
    • Chevalier RL, Forbes MS, Thornhill BA 2009 Ureteral obstruction as a model of renal interstitial fibrosis and obstructive nephropathy. Kidney Int 75:1145-1152
    • (2009) Kidney Int , vol.75 , pp. 1145-1152
    • Chevalier, R.L.1    Forbes, M.S.2    Thornhill, B.A.3
  • 3
    • 33644595207 scopus 로고    scopus 로고
    • Physiology and molecular biology of the relaxin peptide family
    • Neill JD, ed. New York: Raven Press
    • Bathgate RA, Hsueh AJ, Sherwood OD 2006 Physiology and molecular biology of the relaxin peptide family. In: Neill JD, ed. The physiology of reproduction. New York: Raven Press; 701-790
    • (2006) The Physiology of Reproduction , pp. 701-790
    • Bathgate, R.A.1    Hsueh, A.J.2    Sherwood, O.D.3
  • 4
    • 3042610399 scopus 로고    scopus 로고
    • Relaxin's physiological roles and other diverse actions
    • Sherwood OD 2004 Relaxin's physiological roles and other diverse actions. Endocr Rev 25:205-234
    • (2004) Endocr Rev , vol.25 , pp. 205-234
    • Sherwood, O.D.1
  • 12
    • 24944542890 scopus 로고    scopus 로고
    • The antifibrotic effects of relaxin in human renal fibroblasts are mediated in part by inhibition of the Smad2 pathway
    • Heeg MH, Koziolek MJ, Vasko R, Schaefer L, Sharma K, Müller GA, Strutz F 2005 The antifibrotic effects of relaxin in human renal fibroblasts are mediated in part by inhibition of the Smad2 pathway. Kidney Int 68:96-109
    • (2005) Kidney Int , vol.68 , pp. 96-109
    • Heeg, M.H.1    Koziolek, M.J.2    Vasko, R.3    Schaefer, L.4    Sharma, K.5    Müller, G.A.6    Strutz, F.7
  • 15
    • 47849084197 scopus 로고    scopus 로고
    • Relaxin as a natural agent for vascular health
    • Bani D 2008 Relaxin as a natural agent for vascular health. Vasc Health Risk Manag 4:515-524
    • (2008) Vasc Health Risk Manag , vol.4 , pp. 515-524
    • Bani, D.1
  • 16
    • 33748936323 scopus 로고    scopus 로고
    • Specific molecular targeting of renal injury in obstructive nephropathy
    • Chevalier RL 2006 Specific molecular targeting of renal injury in obstructive nephropathy. Kidney Int 70:1200-1201
    • (2006) Kidney Int , vol.70 , pp. 1200-1201
    • Chevalier, R.L.1
  • 20
    • 60349084581 scopus 로고    scopus 로고
    • Determination of collagen content, concentration, and sub-types in kidney tissue
    • Samuel CS 2009 Determination of collagen content, concentration, and sub-types in kidney tissue. Methods Mol Biol 466:223-235
    • (2009) Methods Mol Biol , vol.466 , pp. 223-235
    • Samuel, C.S.1
  • 21
    • 60349109665 scopus 로고    scopus 로고
    • Identification of apoptosis in kidney tissue sections
    • Gobe G 2009 Identification of apoptosis in kidney tissue sections. Methods Mol Biol 466:175-192
    • (2009) Methods Mol Biol , vol.466 , pp. 175-192
    • Gobe, G.1
  • 22
    • 0025215307 scopus 로고
    • Mechanism of activation of latent transforming growth factor β1 by plasmin
    • Lyons RM, Gentry LE, Purchio AF, Moses HL 1990 Mechanism of activation of latent transforming growth factor β1 by plasmin. J Cell Biol 110:1361-1367
    • (1990) J Cell Biol , vol.110 , pp. 1361-1367
    • Lyons, R.M.1    Gentry, L.E.2    Purchio, A.F.3    Moses, H.L.4
  • 23
    • 0029001584 scopus 로고
    • Quantification of matrix metalloproteinases in tissue samples
    • Woessner Jr JF 1995 Quantification of matrix metalloproteinases in tissue samples. Methods Enzymol 248:510-528
    • (1995) Methods Enzymol , vol.248 , pp. 510-528
    • Woessner Jr., J.F.1
  • 24
    • 33744946031 scopus 로고    scopus 로고
    • Matrix metalloproteinase-2 activity, protein, mRNA, and tissue inhibitors in small arteries from pregnant and relaxin-treated nonpregnant rats
    • Jeyabalan A, Kerchner LJ, Fisher MC, McGuane JT, Doty KD, Conrad KP 2006 Matrix metalloproteinase-2 activity, protein, mRNA, and tissue inhibitors in small arteries from pregnant and relaxin-treated nonpregnant rats. J Appl Physiol 100:1955-1963
    • (2006) J Appl Physiol , vol.100 , pp. 1955-1963
    • Jeyabalan, A.1    Kerchner, L.J.2    Fisher, M.C.3    McGuane, J.T.4    Doty, K.D.5    Conrad, K.P.6
  • 26
    • 33745269545 scopus 로고    scopus 로고
    • Rapamycin attenuates unilateral ureteral obstruction-induced renal fibrosis
    • Wu MJ, Wen MC, Chiu YT, Chiou YY, Shu KH, Tang MJ 2006 Rapamycin attenuates unilateral ureteral obstruction-induced renal fibrosis. Kidney Int 69:2029-2036
    • (2006) Kidney Int , vol.69 , pp. 2029-2036
    • Wu, M.J.1    Wen, M.C.2    Chiu, Y.T.3    Chiou, Y.Y.4    Shu, K.H.5    Tang, M.J.6
  • 27
    • 11144248392 scopus 로고    scopus 로고
    • The extent to which relaxin promotes proliferation and inhibits apoptosis of cervical epithelial and stromal cells is greatest during late pregnancy in rats
    • Lee HY, Zhao S, Fields PA, Sherwood OD 2005 The extent to which relaxin promotes proliferation and inhibits apoptosis of cervical epithelial and stromal cells is greatest during late pregnancy in rats. Endocrinology 146:511-518
    • (2005) Endocrinology , vol.146 , pp. 511-518
    • Lee, H.Y.1    Zhao, S.2    Fields, P.A.3    Sherwood, O.D.4
  • 29
    • 0033392921 scopus 로고    scopus 로고
    • Cyclin kinase inhibitor p21CIP1/WAF1 limits interstitial cell proliferation following ureteric obstruction
    • Hughes J, Brown P, Shankland SJ 1999 Cyclin kinase inhibitor p21CIP1/WAF1 limits interstitial cell proliferation following ureteric obstruction. Am J Physiol 277:F948-F956
    • (1999) Am J Physiol , vol.277
    • Hughes, J.1    Brown, P.2    Shankland, S.J.3
  • 30
    • 33846573898 scopus 로고    scopus 로고
    • Fibroblast differentiation in wound healing and fibrosis
    • Darby IA, Hewitson TD 2007 Fibroblast differentiation in wound healing and fibrosis. Int Rev Cytol 257:143-179
    • (2007) Int Rev Cytol , vol.257 , pp. 143-179
    • Darby, I.A.1    Hewitson, T.D.2
  • 31
    • 34249052899 scopus 로고    scopus 로고
    • Matrix metalloproteinases in kidney disease progression and repair: A case of flipping the coin
    • Ronco P, Lelongt B, Piedagnel R, Chatziantoniou C 2007 Matrix metalloproteinases in kidney disease progression and repair: a case of flipping the coin. Semin Nephrol 27:352-362
    • (2007) Semin Nephrol , vol.27 , pp. 352-362
    • Ronco, P.1    Lelongt, B.2    Piedagnel, R.3    Chatziantoniou, C.4
  • 32
    • 34247884253 scopus 로고    scopus 로고
    • Relaxin-induced matrix metalloproteinase- 9 expression is associated with activation of the NF-κB pathway in human THP-1 cells
    • Ho TY, Yan W, Bagnell CA 2007 Relaxin-induced matrix metalloproteinase- 9 expression is associated with activation of the NF-κB pathway in human THP-1 cells. J Leukoc Biol 81:1303-1310
    • (2007) J Leukoc Biol , vol.81 , pp. 1303-1310
    • Ho, T.Y.1    Yan, W.2    Bagnell, C.A.3
  • 33
    • 1642431870 scopus 로고    scopus 로고
    • Does the relaxin, estrogen and matrix metalloproteinase axis contribute to degradation of TMJ fibrocartilage?
    • discussion 406-407
    • Kapila S 2003 Does the relaxin, estrogen and matrix metalloproteinase axis contribute to degradation of TMJ fibrocartilage? J Musculoskelet Neuronal Interact 3:401-405; discussion 406-407
    • (2003) J Musculoskelet Neuronal Interact , vol.3 , pp. 401-405
    • Kapila, S.1
  • 34
    • 0034765067 scopus 로고    scopus 로고
    • Glioma cell invasion: Regulation of metalloproteinase activity by TGF-β
    • Wick W, Platten M, Weller M 2001 Glioma cell invasion: regulation of metalloproteinase activity by TGF-β. J Neurooncol 53:177-185
    • (2001) J Neurooncol , vol.53 , pp. 177-185
    • Wick, W.1    Platten, M.2    Weller, M.3
  • 35
    • 0035179839 scopus 로고    scopus 로고
    • DDR2 receptor promotes MMP-2-mediated proliferation and invasion by hepatic stellate cells
    • Olaso E, Ikeda K, Eng FJ, Xu L, Wang LH, Lin HC, Friedman SL 2001 DDR2 receptor promotes MMP-2-mediated proliferation and invasion by hepatic stellate cells. J Clin Invest 108:1369-1378
    • (2001) J Clin Invest , vol.108 , pp. 1369-1378
    • Olaso, E.1    Ikeda, K.2    Eng, F.J.3    Xu, L.4    Wang, L.H.5    Lin, H.C.6    Friedman, S.L.7
  • 36
    • 0346120209 scopus 로고    scopus 로고
    • Essential role for vascular gelatinase activity in relaxin-induced renal vasodilation, hyperfiltration, and reduced myogenic reactivity of small arteries
    • Jeyabalan A, Novak J, Danielson LA, Kerchner LJ, Opett SL, Conrad KP 2003 Essential role for vascular gelatinase activity in relaxin-induced renal vasodilation, hyperfiltration, and reduced myogenic reactivity of small arteries. Circ Res 93:1249-1257
    • (2003) Circ Res , vol.93 , pp. 1249-1257
    • Jeyabalan, A.1    Novak, J.2    Danielson, L.A.3    Kerchner, L.J.4    Opett, S.L.5    Conrad, K.P.6
  • 37
    • 2442707596 scopus 로고    scopus 로고
    • The role of vascular endothelial growth factor (VEGF) in renal pathophysiology
    • Schrijvers BF, Flyvbjerg A, De Vriese AS 2004 The role of vascular endothelial growth factor (VEGF) in renal pathophysiology. Kidney Int 65:2003-2017
    • (2004) Kidney Int , vol.65 , pp. 2003-2017
    • Schrijvers, B.F.1    Flyvbjerg, A.2    De Vriese, A.S.3
  • 40
    • 0034917262 scopus 로고    scopus 로고
    • Impaired angiogenesis in the remnant kidney model: II. Vascular endothelial growth factor administration reduces renal fibrosis and stabilizes renal function
    • Kang DH, Hughes J, Mazzali M, Schreiner GF, Johnson RJ 2001 Impaired angiogenesis in the remnant kidney model: II. Vascular endothelial growth factor administration reduces renal fibrosis and stabilizes renal function. J Am Soc Nephrol 12:1448-1457
    • (2001) J Am Soc Nephrol , vol.12 , pp. 1448-1457
    • Kang, D.H.1    Hughes, J.2    Mazzali, M.3    Schreiner, G.F.4    Johnson, R.J.5
  • 41
    • 32644477571 scopus 로고    scopus 로고
    • Obstructive nephropathy: Insights from genetically engineered animals
    • Bascands JL, Schanstra JP 2005 Obstructive nephropathy: Insights from genetically engineered animals. Kidney Int 68:925-937
    • (2005) Kidney Int , vol.68 , pp. 925-937
    • Bascands, J.L.1    Schanstra, J.P.2
  • 42
    • 33750693942 scopus 로고    scopus 로고
    • Signaling mechanism of renal fibrosis in unilateral ureteral obstructive kidney disease in ROCK1 knockout mice
    • Fu P, Liu F, Su S, Wang W, Huang XR, Entman ML, Schwartz RJ, Wei L, Lan HY 2006 Signaling mechanism of renal fibrosis in unilateral ureteral obstructive kidney disease in ROCK1 knockout mice. J Am Soc Nephrol 17:3105-3114
    • (2006) J Am Soc Nephrol , vol.17 , pp. 3105-3114
    • Fu, P.1    Liu, F.2    Su, S.3    Wang, W.4    Huang, X.R.5    Entman, M.L.6    Schwartz, R.J.7    Wei, L.8    Lan, H.Y.9


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.