-
1
-
-
33644589069
-
International Union of Pharmacology LVII: Recommendations for the nomenclature of receptors for relaxin family peptides
-
Bathgate, R.A.; Ivell, R.; Sanborn, B.M.; Sherwood, O.D.; Summers, R.J. International Union of Pharmacology LVII: recommendations for the nomenclature of receptors for relaxin family peptides. Pharmacol. Rev., 2006, 58, 7-31.
-
(2006)
Pharmacol. Rev.
, vol.58
, pp. 7-31
-
-
Bathgate, R.A.1
Ivell, R.2
Sanborn, B.M.3
Sherwood, O.D.4
Summers, R.J.5
-
2
-
-
0037169071
-
Activation of orphan receptors by the hormone relaxin
-
Hsu, S.Y.; Nakabayashi, K.; Nishi, S.; Kumagai, J.; Kudo, M.; Sherwood, O.D.; Hsueh, A.J. Activation of orphan receptors by the hormone relaxin. Science, 2002, 295, 671-674.
-
(2002)
Science
, vol.295
, pp. 671-674
-
-
Hsu, S.Y.1
Nakabayashi, K.2
Nishi, S.3
Kumagai, J.4
Kudo, M.5
Sherwood, O.D.6
Hsueh, A.J.7
-
3
-
-
0037200034
-
INSL3/Leydig insulin-like peptide activates the LGR8 receptor important in testis descent
-
Kumagai, J.; Hsu, S.Y.; Matsumi, H.; Roh, J.S.; Fu, P.; Wade, J.D.; Bathgate, R.A.; Hsueh, A J. INSL3/Leydig insulin-like peptide activates the LGR8 receptor important in testis descent. J. Biol. Chem., 2002, 277, 31283-31286.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 31283-31286
-
-
Kumagai, J.1
Hsu, S.Y.2
Matsumi, H.3
Roh, J.S.4
Fu, P.5
Wade, J.D.6
Bathgate, R.A.7
Hsueh, A.J.8
-
4
-
-
10744224962
-
Identification of relaxin-3/INSL7 as an endogenous ligand for the orphan Gprotein- coupled receptor GPCR135
-
Liu, C.; Eriste, E.; Sutton, S.; Chen, J.; Roland, B.; Kuei, C.; Farmer, N.; Jornvall, H.; Sillard, R.; Lovenberg, T.W. Identification of relaxin-3/INSL7 as an endogenous ligand for the orphan Gprotein- coupled receptor GPCR135. J. Biol. Chem., 2003, 278, 50754-50764.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 50754-50764
-
-
Liu, C.1
Eriste, E.2
Sutton, S.3
Chen, J.4
Roland, B.5
Kuei, C.6
Farmer, N.7
Jornvall, H.8
Sillard, R.9
Lovenberg, T.W.10
-
5
-
-
0346118862
-
Identification of relaxin-3/INSL7 as a ligand for GPCR142
-
Liu, C.; Chen, J.; Sutton, S.; Roland, B.; Kuei, C.; Farmer, N.; Sillard, R.; Lovenberg, T.W. Identification of relaxin-3/INSL7 as a ligand for GPCR142. J. Biol. Chem., 2003, 278, 50765-50770.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 50765-50770
-
-
Liu, C.1
Chen, J.2
Sutton, S.3
Roland, B.4
Kuei, C.5
Farmer, N.6
Sillard, R.7
Lovenberg, T.W.8
-
6
-
-
19944432343
-
INSL5 is a high affinity specific agonist for GPCR142 (GPR100)
-
Liu, C.; Kuei, C.; Sutton, S.; Chen, J.; Bonaventure, P.; Wu, J.; Nepomuceno, D.; Kamme, F.; Tran, D.T.; Zhu, J.; Wilkinson, T.; Bathgate, R.; Eriste, E.; Sillard, R.; Lovenberg, T.W. INSL5 is a high affinity specific agonist for GPCR142 (GPR100). J. Biol. Chem., 2005, 280, 292-300.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 292-300
-
-
Liu, C.1
Kuei, C.2
Sutton, S.3
Chen, J.4
Bonaventure, P.5
Wu, J.6
Nepomuceno, D.7
Kamme, F.8
Tran, D.T.9
Zhu, J.10
Wilkinson, T.11
Bathgate, R.12
Eriste, E.13
Sillard, R.14
Lovenberg, T.W.15
-
7
-
-
47749116027
-
The A-chain of human relaxin family peptides has distinct roles in the binding and activation of the different relaxin family peptide receptors
-
Hossain, M.A.; Rosengren, K.J.; Haugaard-Jonsson, L.M.; Zhang, S.; Layfield, S.; Ferraro, T.; Daly, N.L.; Tregear, G.W.; Wade, J.D.; Bathgate, R.A. The A-chain of human relaxin family peptides has distinct roles in the binding and activation of the different relaxin family peptide receptors. J. Biol. Chem., 2008, 283, 17287-17297.
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 17287-17297
-
-
Hossain, M.A.1
Rosengren, K.J.2
Haugaard-Jonsson, L.M.3
Zhang, S.4
Layfield, S.5
Ferraro, T.6
Daly, N.L.7
Tregear, G.W.8
Wade, J.D.9
Bathgate, R.A.10
-
9
-
-
77954623284
-
Relaxin: Review of biology and potential role in treating heart failure
-
Teichman, S.L.; Unemori, E.; Teerlink, J.R.; Cotter, G.; Metra, M. Relaxin: review of biology and potential role in treating heart failure. Curr. Heart Fail. Rep., 2010, 7, 75-82.
-
(2010)
Curr. Heart Fail. Rep.
, vol.7
, pp. 75-82
-
-
Teichman, S.L.1
Unemori, E.2
Teerlink, J.R.3
Cotter, G.4
Metra, M.5
-
10
-
-
65249190276
-
Relaxin for the treatment of patients with acute heart failure (Pre-RELAX-AHF): A multicentre, randomised, placebo-controlled, parallel-group, dose-finding phase IIb study
-
Teerlink, J.R.; Metra, M.; Felker, G.M.; Ponikowski, P.; Voors, A.A.; Weatherley, B.D.; Marmor, A.; Katz, A.; Grzybowski, J.; Unemori, E.; Teichman, S.L.; Cotter, G. Relaxin for the treatment of patients with acute heart failure (Pre-RELAX-AHF): a multicentre, randomised, placebo-controlled, parallel-group, dose-finding phase IIb study. Lancet, 2009, 373, 1429-1439.
-
(2009)
Lancet
, vol.373
, pp. 1429-1439
-
-
Teerlink, J.R.1
Metra, M.2
Felker, G.M.3
Ponikowski, P.4
Voors, A.A.5
Weatherley, B.D.6
Marmor, A.7
Katz, A.8
Grzybowski, J.9
Unemori, E.10
Teichman, S.L.11
Cotter, G.12
-
12
-
-
0025870325
-
Total synthesis of human relaxin and human relaxin derivatives by solid-phase peptide synthesis and site-directed chain combination
-
Büllesbach, E.E.; Schwabe, C. Total synthesis of human relaxin and human relaxin derivatives by solid-phase peptide synthesis and site-directed chain combination. J. Biol. Chem., 1991, 266, 10754-10761.
-
(1991)
J. Biol. Chem.
, vol.266
, pp. 10754-10761
-
-
Büllesbach, E.E.1
Schwabe, C.2
-
13
-
-
0026497638
-
The receptor-binding site of human relaxin II. A dual prong-binding mechanism
-
Büllesbach, E.E.; Yang, S.; Schwabe, C. The receptor-binding site of human relaxin II. A dual prong-binding mechanism. J. Biol. Chem., 1992, 267, 22957-22960.
-
(1992)
J. Biol. Chem.
, vol.267
, pp. 22957-22960
-
-
Büllesbach, E.E.1
Yang, S.2
Schwabe, C.3
-
14
-
-
0034634628
-
The relaxin receptor-binding site geometry suggests a novel gripping mode of interaction
-
Büllesbach, E.E.; Schwabe, C. The relaxin receptor-binding site geometry suggests a novel gripping mode of interaction. J. Biol. Chem., 2000, 275, 35276-35280.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 35276-35280
-
-
Büllesbach, E.E.1
Schwabe, C.2
-
15
-
-
17144426920
-
The trap-like relaxin-binding site of the leucine-rich G-protein-coupled receptor 7
-
Büllesbach, E.E.; Schwabe, C. The trap-like relaxin-binding site of the leucine-rich G-protein-coupled receptor 7. J. Biol. Chem., 2005, 280, 14051-14056.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 14051-14056
-
-
Büllesbach, E.E.1
Schwabe, C.2
-
16
-
-
0022993432
-
Preparation and properties of porcine relaxin derivatives shortened at the amino terminus of the A chain
-
Büllesbach, E.E.; Schwabe, C. Preparation and properties of porcine relaxin derivatives shortened at the amino terminus of the A chain. Biochemistry, 1986, 25, 5998-6004.
-
(1986)
Biochemistry
, vol.25
, pp. 5998-6004
-
-
Büllesbach, E.E.1
Schwabe, C.2
-
17
-
-
0023656067
-
Relaxin structure. Quasi allosteric effect of the NH2-terminal A-chain helix
-
Büllesbach, E.E.; Schwabe, C. Relaxin structure. Quasi allosteric effect of the NH2-terminal A-chain helix. J. Biol. Chem., 1987, 262, 12496-12501.
-
(1987)
J. Biol. Chem.
, vol.262
, pp. 12496-12501
-
-
Büllesbach, E.E.1
Schwabe, C.2
-
18
-
-
17644415042
-
LGR8 signal activation by the relaxin- like factor
-
Büllesbach, E.E.; Schwabe, C. LGR8 signal activation by the relaxin- like factor. J. Biol. Chem., 2005, 280, 14586-14590.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 14586-14590
-
-
Büllesbach, E.E.1
Schwabe, C.2
-
19
-
-
33646832952
-
Solution structure and novel insights into the determinants of the receptor specificity of human relaxin-3
-
Rosengren, K.J.; Lin, F.; Bathgate, R.A.; Tregear, G.W.; Daly, N.L.; Wade, J.D.; Craik, D.J. Solution structure and novel insights into the determinants of the receptor specificity of human relaxin-3. J. Biol. Chem., 2006, 281, 5845-5851.
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 5845-5851
-
-
Rosengren, K.J.1
Lin, F.2
Bathgate, R.A.3
Tregear, G.W.4
Daly, N.L.5
Wade, J.D.6
Craik, D.J.7
-
20
-
-
33748762210
-
Solution structure and characterization of the LGR8 receptor binding surface of insulin-like peptide
-
Rosengren, K.J.; Zhang, S.; Lin, F.; Daly, N.L.; Scott, D.J.; Hughes, R.A.; Bathgate, R.A.; Craik, D.J.; Wade, J.D. Solution structure and characterization of the LGR8 receptor binding surface of insulin-like peptide. J. Biol. Chem., 2006, 281, 28287-28295.
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 28287-28295
-
-
Rosengren, K.J.1
Zhang, S.2
Lin, F.3
Daly, N.L.4
Scott, D.J.5
Hughes, R.A.6
Bathgate, R.A.7
Craik, D.J.8
Wade, J.D.9
-
21
-
-
0025812626
-
X-ray structure of human relaxin at 1.5 A. Comparison to insulin and implications for receptor binding determinants
-
Eigenbrot, C.; Randal, M.; Quan, C.; Burnier, J.; O'Connell, L.; Rinderknecht, E.; Kossiakoff, A. X-ray structure of human relaxin at 1.5 A. Comparison to insulin and implications for receptor binding determinants. J. Mol. Biol., 1991, 221, 15-21.
-
(1991)
J. Mol. Biol.
, vol.221
, pp. 15-21
-
-
Eigenbrot, C.1
Randal, M.2
Quan, C.3
Burnier, J.4
O'Connell, L.5
Rinderknecht, E.6
Kossiakoff, A.7
-
22
-
-
57649131054
-
Regulation of receptor signaling by relaxin A chain motifs: Derivation of pan-specific and LGR7-specific human relaxin analogs
-
Park, J.I.; Semyonov, J.; Yi, W.; Chang, C.L.; Hsu, S.Y. Regulation of receptor signaling by relaxin A chain motifs: derivation of pan-specific and LGR7-specific human relaxin analogs. J. Biol. Chem., 2008, 283, 32099-32109.
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 32099-32109
-
-
Park, J.I.1
Semyonov, J.2
Yi, W.3
Chang, C.L.4
Hsu, S.Y.5
-
23
-
-
23044454976
-
Central relaxin-3 administration causes hyperphagia in male Wistar rats
-
McGowan, B.M.; Stanley, S.A.; Smith, K.L.; White, N.E.; Connolly, M.M.; Thompson, E.L.; Gardiner, J.V.; Murphy, K.G.; Ghatei, M.A.; Bloom, S.R. Central relaxin-3 administration causes hyperphagia in male Wistar rats. Endocrinology, 2005, 146, 3295-3300.
-
(2005)
Endocrinology
, vol.146
, pp. 3295-3300
-
-
McGowan, B.M.1
Stanley, S.A.2
Smith, K.L.3
White, N.E.4
Connolly, M.M.5
Thompson, E.L.6
Gardiner, J.V.7
Murphy, K.G.8
Ghatei, M.A.9
Bloom, S.R.10
-
24
-
-
11244347812
-
Relaxin-3/insulin-like peptide 5 chimeric peptide, a selective ligand for G protein-coupled receptor (GPCR)135 and GPCR142 over leucine-rich repeat-containing G protein-coupled receptor 7
-
Liu, C.; Chen, J.; Kuei, C.; Sutton, S.; Nepomuceno, D.; Bonaventure, P.; Lovenberg, T. W. Relaxin-3/insulin-like peptide 5 chimeric peptide, a selective ligand for G protein-coupled receptor (GPCR)135 and GPCR142 over leucine-rich repeat-containing G protein-coupled receptor 7. Mol. Pharmacol., 2005, 67, 231-240.
-
(2005)
Mol. Pharmacol.
, vol.67
, pp. 231-240
-
-
Liu, C.1
Chen, J.2
Kuei, C.3
Sutton, S.4
Nepomuceno, D.5
Bonaventure, P.6
Lovenberg, T.W.7
-
25
-
-
33747461072
-
Effects of acute and chronic relaxin-3 on food intake and energy expenditure in rats
-
McGowan, B.M.; Stanley, S.A.; Smith, K.L.; Minnion, J.S.; Donovan, J.; Thompson, E.L.; Patterson, M.; Connolly, M.M.; Abbott, C.R.; Small, C.J.; Gardiner, J.V.; Ghatei, M.A.; Bloom, S.R. Effects of acute and chronic relaxin-3 on food intake and energy expenditure in rats. Regul. Pept., 2006, 136, 72-77.
-
(2006)
Regul. Pept.
, vol.136
, pp. 72-77
-
-
McGowan, B.M.1
Stanley, S.A.2
Smith, K.L.3
Minnion, J.S.4
Donovan, J.5
Thompson, E.L.6
Patterson, M.7
Connolly, M.M.8
Abbott, C.R.9
Small, C.J.10
Gardiner, J.V.11
Ghatei, M.A.12
Bloom, S.R.13
-
26
-
-
33646555751
-
Chronic intracerebroventricular administration of relaxin-3 increases body weight in rats
-
Hida, T.; Takahashi, E.; Shikata, K.; Hirohashi, T.; Sawai, T.; Seiki, T.; Tanaka, H.; Kawai, T.; Ito, O.; Arai, T.; Yokoi, A.; Hirakawa, T.; Ogura, H.; Nagasu, T.; Miyamoto, N.; Kuromitsu, J. Chronic intracerebroventricular administration of relaxin-3 increases body weight in rats. J. Recept. Signal. Transduct. Res., 2006, 26, 147-158.
-
(2006)
J. Recept. Signal. Transduct. Res.
, vol.26
, pp. 147-158
-
-
Hida, T.1
Takahashi, E.2
Shikata, K.3
Hirohashi, T.4
Sawai, T.5
Seiki, T.6
Tanaka, H.7
Kawai, T.8
Ito, O.9
Arai, T.10
Yokoi, A.11
Hirakawa, T.12
Ogura, H.13
Nagasu, T.14
Miyamoto, N.15
Kuromitsu, J.16
-
27
-
-
70350675387
-
Modulation of hippocampal theta oscillations and spatial memory by relaxin-3 neurons of the nucleus incertus
-
Ma, S.; Olucha-Bordonau, F.E.; Hossain, M.A.; Lin, F.; Kuei, C.; Liu, C.; Wade, J.D.; Sutton, S.W.; Nunez, A.; Gundlach, A.L. Modulation of hippocampal theta oscillations and spatial memory by relaxin-3 neurons of the nucleus incertus. Learn. Mem., 2009, 16, 730-742.
-
(2009)
Learn. Mem.
, vol.16
, pp. 730-742
-
-
Ma, S.1
Olucha-Bordonau, F.E.2
Hossain, M.A.3
Lin, F.4
Kuei, C.5
Liu, C.6
Wade, J.D.7
Sutton, S.W.8
Nunez, A.9
Gundlach, A.L.10
-
28
-
-
64549090037
-
Probing the functional domains of relaxin-3 and the creation of a selective antagonist for RXFP3/GPCR135 over relaxin receptor RXFP1/LGR7
-
Liu, C.; Kuei, C.; Sutton, S.; Shelton, J.; Zhu, J.; Nepomuceno, D.; Hossain, M.A.; Wade, J.D.; Bathgate, R.A.; Bonaventure, P.; Lovenberg, T. Probing the functional domains of relaxin-3 and the creation of a selective antagonist for RXFP3/GPCR135 over relaxin receptor RXFP1/LGR7. Ann. N. Y. Acad. Sci., 2009, 1160, 31-37.
-
(2009)
Ann. N. Y. Acad. Sci.
, vol.1160
, pp. 31-37
-
-
Liu, C.1
Kuei, C.2
Sutton, S.3
Shelton, J.4
Zhu, J.5
Nepomuceno, D.6
Hossain, M.A.7
Wade, J.D.8
Bathgate, R.A.9
Bonaventure, P.10
Lovenberg, T.11
-
29
-
-
34548471964
-
R3(BDelta23 27)R/I5 chimeric peptide, a selective antagonist for GPCR135 and GPCR142 over relaxin receptor LGR7: In vitro and in vivo characterization
-
Kuei, C.; Sutton, S.; Bonaventure, P.; Pudiak, C.; Shelton, J.; Zhu, J.; Nepomuceno, D.; Wu, J.; Chen, J.; Kamme, F.; Seierstad, M.; Hack, M.D.; Bathgate, R.A.; Hossain, M.A.; Wade, J.D.; Atack, J.; Lovenberg, T.W.; Liu, C. R3(BDelta23 27)R/I5 chimeric peptide, a selective antagonist for GPCR135 and GPCR142 over relaxin receptor LGR7: in vitro and in vivo characterization. J. Biol. Chem., 2007, 282, 25425-25435.
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 25425-25435
-
-
Kuei, C.1
Sutton, S.2
Bonaventure, P.3
Pudiak, C.4
Shelton, J.5
Zhu, J.6
Nepomuceno, D.7
Wu, J.8
Chen, J.9
Kamme, F.10
Seierstad, M.11
Hack, M.D.12
Bathgate, R.A.13
Hossain, M.A.14
Wade, J.D.15
Atack, J.16
Lovenberg, T.W.17
Liu, C.18
|