Optimization of 5-hydroxytryptamines as dual function inhibitors targeting phospholipase A2 and leukotriene A4 hydrolase

European Journal of Medicinal Chemistry

Volumn 59, Issue , 2013, Pages 160-167

  Meng, Hu ^a   Liu, Ying ^a   Zhai, Yujing ^a   Lai, Luhua ^a  

^a PEKING UNIVERSITY   (China)

Author keywords

5 Hydroxytryptamine; Dual function inhibitor; LTA4H; Optimization; PLA2

Indexed keywords

1 (4 METHOXYPHENOXY) 2 NITROBENZENE; 1 [4 (2 BROMOETHOXY)PHENOXY]BENZENE; 2 [5 (3 PHENOXYBENZYLOXY) 1H INDOL 3 YL]ETHANAMINIUM CHLORIDE; 2 [5 (4 PHENYLBENZYLOXY) 1H INDOL 3 YL]ETHANAMINIUM CHLORIDE; 2 [5 (BENZYLOXY) 1H INDOL 3 YL]ETHANAMINIUM CHLORIDE; 2 [5 (NAPHTHALEN 1 YL METHOXY) 1H INDOL 3 YL]ETHANAMINIUM CHLORIDE; 2 [5 (NAPHTHALEN 2 YL METHOXY) 1H INDOL 3 YL]ETHANAMINIUM CHLORIDE; 2 [5 [2 (4 PHENOXYPHENOXY)ETHOXY] 1H INDOL 3 YL]ETHANAMINIUM CHLORIDE; 2 [5 [2 [4 (2 NITROPHENOXY)PHENOXY]ETHOXY] 1H INDOL 3 YL]ETHANAMINIUM CHLORIDE; 4 (2 NITROPHENOXY) PHENOL; LEUKOTRIENE A4 HYDROLASE; N (BUTYLOXYCARBONYL)SEROTONIN; PHOSPHOLIPASE A2; SEROTONIN DERIVATIVE; TERTBUTYL 2 [5 (NAPHTHALEN 2 YLMETHOXY) 1H INDOL 3 YL]ETHYLCARBAMATE; TERTBUTYL 2 [5 [2 (4 PHENOXYPHENOXY)ETHOXY] 1H INDOL 3 YL]ETHYLCARBAMATE; UNCLASSIFIED DRUG;

ARTICLE; DRUG INHIBITION; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; IC 50; IN VITRO STUDY; INHIBITION KINETICS; MOLECULAR DOCKING;

BINDING SITES; CRYSTALLOGRAPHY, X-RAY; DRUG DELIVERY SYSTEMS; ENZYME ACTIVATION; ENZYME INHIBITORS; EPOXIDE HYDROLASES; HUMANS; INDOLES; INHIBITORY CONCENTRATION 50; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PHOSPHOLIPASES A2; PROPIONATES; SEROTONIN; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84870342299     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2012.10.057     Document Type: Article

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