Discovery of dual target inhibitors against cyclooxygenases and leukotriene A4 hydrolyase

Journal of Medicinal Chemistry

Volumn 54, Issue 10, 2011, Pages 3650-3660

  Chen, Zheng ^a   Wu, Yiran ^a   Liu, Ying ^a   Yang, Suijia ^a   Chen, Yunjie ^a   Lai, Luhua ^a  

^a PEKING UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

1 [2 [4 (2 NITROPHENOXY)PHENOXY]ETHYL]PYRROLIDINE; 1 [2 [4 [2 (TRIFLUOROMETHYL)PHENOXY]PHENOXY]ETHYL]PYRROLIDINE; CYCLOOXYGENASE 2 INHIBITOR; HYDROLYASE INHIBITOR; NIMESULIDE; PYRROLIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; DRUG ACTIVITY; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; IC 50;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CHEMISTRY, PHARMACEUTICAL; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE INHIBITORS; DRUG DESIGN; ENZYME INHIBITORS; EPOXIDE HYDROLASES; HUMANS; INHIBITORY CONCENTRATION 50; MODELS, CHEMICAL; MOLECULAR CONFORMATION; PROTEIN BINDING;

EID: 79957718287     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm200063s     Document Type: Article

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