Engineered disulfide-forming amino acid substitutions interfere with a conformational change in the mismatch recognition complex Msh2-Msh6 required for mismatch repair

Journal of Biological Chemistry

Volumn 287, Issue 49, 2012, Pages 41232-41244

  Hargreaves, Victoria V ^a   Putnam, Christopher D ^a   Kolodner, Richard D ^a  

^a LUDWIG INSTITUTE FOR CANCER RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID SUBSTITUTION; ATP BINDING; C-TERMINAL REGIONS; CLEAVAGE SITES; CONFORMATIONAL CHANGE; DISULFIDE BONDS; IN-VIVO; MISMATCH REPAIR;

AMINO ACIDS; COVALENT BONDS;

REPAIR;

ARGININE; DISULFIDE; PROTEIN MSH2; PROTEIN MSH6; TRYPSIN;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CONFORMATIONAL TRANSITION; GENETIC ENGINEERING; IN VIVO STUDY; MISMATCH REPAIR; MOLECULAR RECOGNITION; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CLEAVAGE; PROTEIN DETERMINATION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION;

ADENOSINE TRIPHOSPHATE; AMINO ACIDS; BASE PAIR MISMATCH; BINDING SITES; CROSS-LINKING REAGENTS; DISULFIDES; DNA MISMATCH REPAIR; DNA-BINDING PROTEINS; HUMANS; HYDROLYSIS; MUTS HOMOLOG 2 PROTEIN; OXYGEN; PROTEIN CONFORMATION; PROTEIN ENGINEERING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; SURFACE PLASMON RESONANCE; TRYPSIN;

EID: 84870330137     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.402495     Document Type: Article

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