Deciphering the molecular bases of the biological effects of antibodies against Interleukin-2: A versatile platform for fine epitope mapping

Immunobiology

Volumn 218, Issue 1, 2013, Pages 105-113

  Rojas, Gertrudis ^a   Pupo, Amaury ^a   Leon, Kalet ^a   Avellanet, Janet ^a   Carmenate, Tania ^a   Sidhu, Sachdev ^b  

^a CENTER OF MOLECULAR IMMUNOLOGY   (Cuba)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

Cytokine receptor; Epitope mapping; Interleukin 2; Phage display; Site directed mutagenesis; Structure function relationship

Indexed keywords

CYTOKINE RECEPTOR; INTERLEUKIN 2; INTERLEUKIN 2 ANTIBODY; MONOCLONAL ANTIBODY; PROTEIN ANTIBODY; UNCLASSIFIED DRUG;

ARTICLE; BACTERIOPHAGE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; EPITOPE MAPPING; HIGH THROUGHPUT SCREENING; HUMAN; IMMUNE RESPONSE; IMMUNE SYSTEM; NONHUMAN; PREDICTION; PRIORITY JOURNAL; PROTEIN STRUCTURE; SITE DIRECTED MUTAGENESIS; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGEN-ANTIBODY REACTIONS; CELL SURFACE DISPLAY TECHNIQUES; EPITOPE MAPPING; EPITOPES; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; IMMUNITY, HUMORAL; INTERLEUKIN-2; MICE; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; MUTATION; PEPTIDE FRAGMENTS; PROTEIN BINDING; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84870291522     PISSN: 01712985     EISSN: 18783279     Source Type: Journal    
DOI: 10.1016/j.imbio.2012.02.009     Document Type: Article

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