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Volumn 180, Issue 7, 2008, Pages 5118-5129

IL-2/Anti-IL-2 antibody complex enhances vaccine-mediated antigen-specific CD8+ T cell responses and increases the ratio of effector/memory CD8+ T cells to regulatory T cells

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; INTERLEUKIN 2; INTERLEUKIN 2 ANTIBODY; UNCLASSIFIED DRUG; VIRUS VACCINE; ANTIGEN; GAMMA INTERFERON; VACCINE;

EID: 44449145525     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.180.7.5118     Document Type: Article
Times cited : (31)

References (45)
  • 1
    • 33746547247 scopus 로고    scopus 로고
    • The biology of interleukin-2 and interleukin-15: Implications for cancer therapy and vaccine design
    • Waldmann, T. A. 2006. The biology of interleukin-2 and interleukin-15: implications for cancer therapy and vaccine design. Nat. Rev. Immunol. 6: 595-601.
    • (2006) Nat. Rev. Immunol , vol.6 , pp. 595-601
    • Waldmann, T.A.1
  • 3
    • 0036839499 scopus 로고    scopus 로고
    • + T cells increases the size of the acute antiviral response and of the resulting memory T cell pool
    • + T cells increases the size of the acute antiviral response and of the resulting memory T cell pool. J. Immunol. 169: 4990-4997.
    • (2002) J. Immunol , vol.169 , pp. 4990-4997
    • Cheng, L.E.1    Greenberg, P.D.2
  • 5
    • 33645465526 scopus 로고    scopus 로고
    • Selective stimulation of T cell subsets with antibody-cytokine immune complexes
    • Boyman, O., M. Kovar, M. P. Rubinstein, C. D. Surh, and J. Sprent. 2006. Selective stimulation of T cell subsets with antibody-cytokine immune complexes. Science 311: 1924-1927.
    • (2006) Science , vol.311 , pp. 1924-1927
    • Boyman, O.1    Kovar, M.2    Rubinstein, M.P.3    Surh, C.D.4    Sprent, J.5
  • 6
    • 13544265658 scopus 로고    scopus 로고
    • IL-2 and autocrine IL-4 drive the in vivo development of antigen-specific Th2 T cells elicited by nematode parasites
    • Liu, Z., Q. Liu, H. Hamed, R. M. Anthony, A. Foster, F. D. Finkelman, J. F. Urban, Jr., and W. C. Gause. 2005. IL-2 and autocrine IL-4 drive the in vivo development of antigen-specific Th2 T cells elicited by nematode parasites. J. Immunol. 174: 2242-2249.
    • (2005) J. Immunol , vol.174 , pp. 2242-2249
    • Liu, Z.1    Liu, Q.2    Hamed, H.3    Anthony, R.M.4    Foster, A.5    Finkelman, F.D.6    Urban Jr., J.F.7    Gause, W.C.8
  • 7
    • 0035865460 scopus 로고    scopus 로고
    • + T cell clones in older mice is controlled by cytokines
    • + T cell clones in older mice is controlled by cytokines. J. Immunol. 166:2186 -2193.
    • (2001) J. Immunol , vol.166 , pp. 2186-2193
    • Ku, C.C.1    Kappler, J.2    Marrack, P.3
  • 8
    • 0001585396 scopus 로고    scopus 로고
    • Control of homeostasis of CD8+ memory T cells by opposing cytokines
    • Ku, C. C., M. Murakami, A. Sakamoto, J. Kappler, and P. Marrack. 2000. Control of homeostasis of CD8+ memory T cells by opposing cytokines. Science 288:675-678.
    • (2000) Science , vol.288 , pp. 675-678
    • Ku, C.C.1    Murakami, M.2    Sakamoto, A.3    Kappler, J.4    Marrack, P.5
  • 11
    • 33745306112 scopus 로고    scopus 로고
    • IL-2 in vivo activities and antitumor efficacy enhanced by an anti-IL-2 mAb
    • Kamimura, D., Y. Sawa, M. Sato, E. Agung, T. Hirano, and M. Murakami. 2006. IL-2 in vivo activities and antitumor efficacy enhanced by an anti-IL-2 mAb. J. Immunol. 177: 306 -314.
    • (2006) J. Immunol , vol.177 , pp. 306-314
    • Kamimura, D.1    Sawa, Y.2    Sato, M.3    Agung, E.4    Hirano, T.5    Murakami, M.6
  • 12
    • 15444374646 scopus 로고    scopus 로고
    • + regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization
    • + regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization. J. Exp. Med. 201:723-735.
    • (2005) J. Exp. Med , vol.201 , pp. 723-735
    • Setoguchi, R.1    Hori, S.2    Takahashi, T.3    Sakaguchi, S.4
  • 13
    • 0028316271 scopus 로고
    • Pharmacokinetic alteration in rats of recombinant interleukin-2 (rIL-2) by immu- nocomplexing with a monoclonal antibody against rIL-2
    • Sato, J., N. Hamaguchi, K. Doken, S. Iwasa, Y. Ogawa, and H. Toguchi. 1994. Pharmacokinetic alteration in rats of recombinant interleukin-2 (rIL-2) by immu- nocomplexing with a monoclonal antibody against rIL-2. Biol. Pharm. Bull. 17:535-538.
    • (1994) Biol. Pharm. Bull , vol.17 , pp. 535-538
    • Sato, J.1    Hamaguchi, N.2    Doken, K.3    Iwasa, S.4    Ogawa, Y.5    Toguchi, H.6
  • 14
    • 0028900662 scopus 로고
    • Pharmaco- kinetic study of anti-interleukin-6 (IL-6) therapy with monoclonal antibodies: Enhancement of IL-6 clearance by cocktails of anti-IL-6 antibodies
    • Montero-Julian, F. A., B. Klein, E. Gautherot, and H. Brailly. 1995. Pharmaco- kinetic study of anti-interleukin-6 (IL-6) therapy with monoclonal antibodies: enhancement of IL-6 clearance by cocktails of anti-IL-6 antibodies. Blood 85:917-924.
    • (1995) Blood , vol.85 , pp. 917-924
    • Montero-Julian, F.A.1    Klein, B.2    Gautherot, E.3    Brailly, H.4
  • 16
    • 0027320006 scopus 로고
    • Enhancement of the biologic effects of interleukin-3 in vivo by anti-interleukin-3 antibodies
    • Jones, A. T., and H. J. Ziltener. 1993. Enhancement of the biologic effects of interleukin-3 in vivo by anti-interleukin-3 antibodies. Blood 82: 1133-1141.
    • (1993) Blood , vol.82 , pp. 1133-1141
    • Jones, A.T.1    Ziltener, H.J.2
  • 17
    • 0027199745 scopus 로고
    • Increased circulating interleukin-6 (IL-6) activity in endotoxin-challenged mice pretreated with anti-IL-6 antibody is due to IL-6 accumulated in antigen- antibody complexes
    • Martens, E., C. Dillen, W. Put, H. Heremans, J. van Damme, and A. Billiau. 1993. Increased circulating interleukin-6 (IL-6) activity in endotoxin-challenged mice pretreated with anti-IL-6 antibody is due to IL-6 accumulated in antigen- antibody complexes. Eur. J. Immunol. 23: 2026 -2029.
    • (1993) Eur. J. Immunol , vol.23 , pp. 2026-2029
    • Martens, E.1    Dillen, C.2    Put, W.3    Heremans, H.4    van Damme, J.5    Billiau, A.6
  • 18
    • 0027239843 scopus 로고
    • Anti-cytokine antibodies as carrier proteins: Prolongation of in vivo effects of exogenous cytokines by injection of cytokine-anti-cytokine antibody complexes
    • Finkelman, F. D., K. B. Madden, S. C. Morris, J. M. Holmes, N. Boiani, I. M. Katona, and C. R. Maliszewski. 1993. Anti-cytokine antibodies as carrier proteins: prolongation of in vivo effects of exogenous cytokines by injection of cytokine-anti-cytokine antibody complexes. J. Immunol. 151: 1235-1244.
    • (1993) J. Immunol , vol.151 , pp. 1235-1244
    • Finkelman, F.D.1    Madden, K.B.2    Morris, S.C.3    Holmes, J.M.4    Boiani, N.5    Katona, I.M.6    Maliszewski, C.R.7
  • 19
    • 0027372545 scopus 로고
    • Enhancement of anti-tumor activity of recombinant interleu- kin-2 (rIL-2) by immunocomplexing with a monoclonal antibody against rIL-2
    • Sato, J., N. Hamaguchi, K. Doken, K. Gotoh, K. Ootsu, S. Iwasa, Y. Ogawa, and H. Toguchi. 1993. Enhancement of anti-tumor activity of recombinant interleu- kin-2 (rIL-2) by immunocomplexing with a monoclonal antibody against rIL-2. Biotherapy 6: 225-231.
    • (1993) Biotherapy , vol.6 , pp. 225-231
    • Sato, J.1    Hamaguchi, N.2    Doken, K.3    Gotoh, K.4    Ootsu, K.5    Iwasa, S.6    Ogawa, Y.7    Toguchi, H.8
  • 20
    • 0028111158 scopus 로고
    • Enhancement of the anti-tumor activity of recombinant inter- leukin-2 (rIL-2) by immunocomplexing with an F(ab')2 fragment of murine monoclonal antibody against rIL-2
    • Sato, J., N. Hamaguchi, K. Doken, K. Gotoh, K. Ootsu, S. Iwasa, Y. Ogawa, and H. Toguchi. 1994. Enhancement of the anti-tumor activity of recombinant inter- leukin-2 (rIL-2) by immunocomplexing with an F(ab')2 fragment of murine monoclonal antibody against rIL-2. Biol. Pharm. Bull. 17: 1101-1105.
    • (1994) Biol. Pharm. Bull , vol.17 , pp. 1101-1105
    • Sato, J.1    Hamaguchi, N.2    Doken, K.3    Gotoh, K.4    Ootsu, K.5    Iwasa, S.6    Ogawa, Y.7    Toguchi, H.8
  • 21
    • 0028134983 scopus 로고
    • An anti-IL-2 antibody increases serum half-life and improves anti-tumor efficacy of human recombinant interleukin-2
    • Courtney, L. P., J. L. Phelps, and L. M. Karavodin. 1994. An anti-IL-2 antibody increases serum half-life and improves anti-tumor efficacy of human recombinant interleukin-2. Immunopharmacology 28: 223-232.
    • (1994) Immunopharmacology , vol.28 , pp. 223-232
    • Courtney, L.P.1    Phelps, J.L.2    Karavodin, L.M.3
  • 22
    • 0027240729 scopus 로고
    • Antibodies chaperone circulating IL-6: Paradoxical effects of anti-IL-6 "neutralizing" antibodies in vivo
    • May, L. T., R. Neta, L. L. Moldawer, J. S. Kenney, K. Patel, and P. B. Sehgal. 1993. Antibodies chaperone circulating IL-6: paradoxical effects of anti-IL-6 "neutralizing" antibodies in vivo. J. Immunol 151: 3225-3236.
    • (1993) J. Immunol , vol.151 , pp. 3225-3236
    • May, L.T.1    Neta, R.2    Moldawer, L.L.3    Kenney, J.S.4    Patel, K.5    Sehgal, P.B.6
  • 23
    • 2442664146 scopus 로고    scopus 로고
    • Proinflammatory activity of anti-IL-8 autoantibody:IL-8 complexes in alveolar edema fluid from patients with acute lung injury
    • Krupa, A., H. Kato, M. A. Matthay, and A. K. Kurdowska. 2004. Proinflammatory activity of anti-IL-8 autoantibody:IL-8 complexes in alveolar edema fluid from patients with acute lung injury. Am. J. Physiol. 286: L1105-L1113.
    • (2004) Am. J. Physiol , vol.286
    • Krupa, A.1    Kato, H.2    Matthay, M.A.3    Kurdowska, A.K.4
  • 24
    • 0035695728 scopus 로고    scopus 로고
    • Treatment with anti-interferon-γ monoclonal antibodies modifies experimental autoimmune encephalomyelitis in interferon-y receptor knockout mice
    • Espejo, C., M. Penkowa, I. Saez-Torres, J. Xaus, A. Celada, X. Montalban, and E. M. Martinez-Caceres. 2001. Treatment with anti-interferon-γ monoclonal antibodies modifies experimental autoimmune encephalomyelitis in interferon-y receptor knockout mice. Exp. Neurol. 172: 460 -468.
    • (2001) Exp. Neurol , vol.172 , pp. 460-468
    • Espejo, C.1    Penkowa, M.2    Saez-Torres, I.3    Xaus, J.4    Celada, A.5    Montalban, X.6    Martinez-Caceres, E.M.7
  • 25
    • 0027281205 scopus 로고
    • The enhancement of human tumor necrosis factor-α antiviral activity in vivo by monoclonal and specific polyclonal antibodies
    • Lidbury, B. A., R. Aston, I. A. Ramshaw, W. B. Cowden, and D. A. Rathjen. 1993. The enhancement of human tumor necrosis factor-α antiviral activity in vivo by monoclonal and specific polyclonal antibodies. Lymphokine Cytokine Res. 12: 69 -74.
    • (1993) Lymphokine Cytokine Res , vol.12 , pp. 69-74
    • Lidbury, B.A.1    Aston, R.2    Ramshaw, I.A.3    Cowden, W.B.4    Rathjen, D.A.5
  • 26
    • 0026568684 scopus 로고
    • Conjugated anti-TNF antibodies enhance the binding and degradation of TNF
    • Lee, V. W., M. H. Coan, and C. J. Galloway. 1992. Conjugated anti-TNF antibodies enhance the binding and degradation of TNF. Biotechnol. Ther. 3: 51-62.
    • (1992) Biotechnol. Ther , vol.3 , pp. 51-62
    • Lee, V.W.1    Coan, M.H.2    Galloway, C.J.3
  • 27
    • 34548850862 scopus 로고    scopus 로고
    • Rapid generation of a functional NK-cell compartment
    • Prlic, M., D. Kamimura, and M. J. Bevan. 2007. Rapid generation of a functional NK-cell compartment. Blood 110: 2024-2026.
    • (2007) Blood , vol.110 , pp. 2024-2026
    • Prlic, M.1    Kamimura, D.2    Bevan, M.J.3
  • 28
    • 34547824186 scopus 로고    scopus 로고
    • Naive CD8kin-2 (rIL-2) by immunocomplexing with a monoclonal antibody against rIL-2. Biotherapy 6: 225-231. T cells differentiate into protective memory-like cells after IL-2 anti IL-2 complex treatment in vivo
    • Kamimura, D., and M. J. Bevan. 2007. Naive CD8kin-2 (rIL-2) by immunocomplexing with a monoclonal antibody against rIL-2. Biotherapy 6: 225-231. T cells differentiate into protective memory-like cells after IL-2 anti IL-2 complex treatment in vivo. J. Exp. Med. 204: 1803-1812.
    • (2007) J. Exp. Med , vol.204 , pp. 1803-1812
    • Kamimura, D.1    Bevan, M.J.2
  • 29
    • 34547767555 scopus 로고    scopus 로고
    • An intense form of homeostatic proliferation of naive CD8kin-2 (rIL-2) by immunocomplexing with a monoclonal antibody against rIL-2. Biotherapy 6: 225-231. cells driven by IL-2
    • Cho, J. H., O. Boyman, H. O. Kim, B. Hahm, M. P. Rubinstein, C. Ramsey, D. M. Kim, C. D. Surh, and J. Sprent. 2007. An intense form of homeostatic proliferation of naive CD8kin-2 (rIL-2) by immunocomplexing with a monoclonal antibody against rIL-2. Biotherapy 6: 225-231. cells driven by IL-2. J. Exp. Med. 204: 1787-1801.
    • (2007) J. Exp. Med , vol.204 , pp. 1787-1801
    • Cho, J.H.1    Boyman, O.2    Kim, H.O.3    Hahm, B.4    Rubinstein, M.P.5    Ramsey, C.6    Kim, D.M.7    Surh, C.D.8    Sprent, J.9
  • 31
    • 33750335080 scopus 로고    scopus 로고
    • Combined IL-15/IL- 15Rα immunotherapy maximizes IL-15 activity in vivo
    • Stoklasek, T. A., K. S. Schluns, and L. Lefrancois. 2006. Combined IL-15/IL- 15Rα immunotherapy maximizes IL-15 activity in vivo. J. Immunol. 177:6072-6080.
    • (2006) J. Immunol , vol.177 , pp. 6072-6080
    • Stoklasek, T.A.1    Schluns, K.S.2    Lefrancois, L.3
  • 32
    • 0022483534 scopus 로고
    • The epitopes of influenza nucleoprotein recognized by cytotoxic T lymphocytes can be defined with short synthetic peptides
    • Townsend, A. R., J. Rothbard, F. M. Gotch, G. Bahadur, D. Wraith, and A. J. McMichael. 1986. The epitopes of influenza nucleoprotein recognized by cytotoxic T lymphocytes can be defined with short synthetic peptides. Cell 44:959 -968.
    • (1986) Cell , vol.44 , pp. 959-968
    • Townsend, A.R.1    Rothbard, J.2    Gotch, F.M.3    Bahadur, G.4    Wraith, D.5    McMichael, A.J.6
  • 33
    • 0027711831 scopus 로고
    • Positive and negative selection in transgenic mice expressing a T-cell receptor specific for influenza nucleoprotein and endogenous superantigen
    • Mamalaki, C., J. Elliott, T. Norton, N. Yannoutsos, A. R. Townsend, P. Chandler, E. Simpson, and D. Kioussis. 1993. Positive and negative selection in transgenic mice expressing a T-cell receptor specific for influenza nucleoprotein and endogenous superantigen. Dev. Immunol. 3: 159 -174.
    • (1993) Dev. Immunol , vol.3 , pp. 159-174
    • Mamalaki, C.1    Elliott, J.2    Norton, T.3    Yannoutsos, N.4    Townsend, A.R.5    Chandler, P.6    Simpson, E.7    Kioussis, D.8
  • 34
    • 0036200852 scopus 로고    scopus 로고
    • Visualizing priming of virus-specific CD8kin-2 (rIL-2) by immunocomplexing with a monoclonal antibody against rIL-2. Biotherapy 6: 225-231. T cells by infected dendritic cells in vivo
    • Norbury, C. C., D. Malide, J. S. Gibbs, J. R. Bennink, and J. W. Yewdell. 2002. Visualizing priming of virus-specific CD8kin-2 (rIL-2) by immunocomplexing with a monoclonal antibody against rIL-2. Biotherapy 6: 225-231. T cells by infected dendritic cells in vivo. Nat. Immunol. 3: 265-271.
    • (2002) Nat. Immunol , vol.3 , pp. 265-271
    • Norbury, C.C.1    Malide, D.2    Gibbs, J.S.3    Bennink, J.R.4    Yewdell, J.W.5
  • 35
    • 0033571120 scopus 로고    scopus 로고
    • A triad of costimulatory molecules synergize to amplify T-cell activation
    • Hodge, J. W., H. Sabzevari, A. G. Yafal, L. Gritz, M. G. Lorenz, and J. Schlom. 1999. A triad of costimulatory molecules synergize to amplify T-cell activation. Cancer Res. 59: 5800 -5807.
    • (1999) Cancer Res , vol.59 , pp. 5800-5807
    • Hodge, J.W.1    Sabzevari, H.2    Yafal, A.G.3    Gritz, L.4    Lorenz, M.G.5    Schlom, J.6
  • 36
    • 15244351311 scopus 로고    scopus 로고
    • Comparative studies of Avipox-GM-CSF versus recombinant GM-CSF protein as immune adjuvants with different vaccine platforms
    • Reali, E., D. Canter, H. Zeytin, J. Schlom, and J. W. Greiner. 2005. Comparative studies of Avipox-GM-CSF versus recombinant GM-CSF protein as immune adjuvants with different vaccine platforms. Vaccine 23: 2909 -2921.
    • (2005) Vaccine , vol.23 , pp. 2909-2921
    • Reali, E.1    Canter, D.2    Zeytin, H.3    Schlom, J.4    Greiner, J.W.5
  • 37
    • 37049066500 scopus 로고
    • Synthesis of C-functionalized trans-cyclo- hexyldiethylenetriaminepenta-acetic acids for labelling of monoclonal antibodies with the bismuth-212-particle emitter
    • Brechbiel, M., and O. Gansow. 1992. Synthesis of C-functionalized trans-cyclo- hexyldiethylenetriaminepenta-acetic acids for labelling of monoclonal antibodies with the bismuth-212-particle emitter. J. Chem. Soc. Perkin Trans. 1 1173-1178.
    • (1992) J. Chem. Soc. Perkin Trans , vol.1 , pp. 1173-1178
    • Brechbiel, M.1    Gansow, O.2
  • 40
    • 0026889408 scopus 로고
    • Spec- trophotometric method for the determination of a bifunctional DTPA ligand in DTPA-monoclonal antibody conjugates
    • Pippin, C. G., T. A. Parker, T. J. McMurry, and M. W. Brechbiel. 1992. Spec- trophotometric method for the determination of a bifunctional DTPA ligand in DTPA-monoclonal antibody conjugates. Bioconjug. Chem. 3: 342-345.
    • (1992) Bioconjug. Chem , vol.3 , pp. 342-345
    • Pippin, C.G.1    Parker, T.A.2    McMurry, T.J.3    Brechbiel, M.W.4
  • 41
    • 0020586786 scopus 로고
    • The fate of interleukin-2 after in vivo administration
    • Donohue, J. H., and S. A. Rosenberg. 1983. The fate of interleukin-2 after in vivo administration. J. Immunol. 130: 2203-2208.
    • (1983) J. Immunol , vol.130 , pp. 2203-2208
    • Donohue, J.H.1    Rosenberg, S.A.2
  • 42
    • 33745206906 scopus 로고    scopus 로고
    • Neutralization of interleukin-2 retards the growth of mouse renal cancer
    • Fukuhara, H., A. Matsumoto, T. Kitamura, and T. Takeuchi. 2006. Neutralization of interleukin-2 retards the growth of mouse renal cancer. BJU Int. 97:1314-1321.
    • (2006) BJU Int , vol.97 , pp. 1314-1321
    • Fukuhara, H.1    Matsumoto, A.2    Kitamura, T.3    Takeuchi, T.4
  • 43
    • 30744458573 scopus 로고    scopus 로고
    • Lymphopenia and interleukin-2 therapy alter homeostasis of CD4kin-2 (rIL-2) by immunocomplexing with a monoclonal antibody against rIL-2. Biotherapy 6: 225-231.CD25kin-2 (rIL-2) by immunocomplexing with a monoclonal antibody against rIL-2. Biotherapy 6: 225-231. regulatory T cells
    • Zhang, H., K. S. Chua, M. Guimond, V. Kapoor, M. V. Brown, T. A. Fleisher, L. M. Long, D. Bernstein, B. J. Hill, D. C. Douek, et al. 2005. Lymphopenia and interleukin-2 therapy alter homeostasis of CD4kin-2 (rIL-2) by immunocomplexing with a monoclonal antibody against rIL-2. Biotherapy 6: 225-231.CD25kin-2 (rIL-2) by immunocomplexing with a monoclonal antibody against rIL-2. Biotherapy 6: 225-231. regulatory T cells. Nat. Med. 11: 1238 -1243.
    • (2005) Nat. Med , vol.11 , pp. 1238-1243
    • Zhang, H.1    Chua, K.S.2    Guimond, M.3    Kapoor, V.4    Brown, M.V.5    Fleisher, T.A.6    Long, L.M.7    Bernstein, D.8    Hill, B.J.9    Douek, D.C.10
  • 44
    • 33644784733 scopus 로고    scopus 로고
    • + regulatory T cells in cancer patients
    • + regulatory T cells in cancer patients. Blood 107:2409 -2414.
    • (2006) Blood , vol.107 , pp. 2409-2414
    • Ahmadzadeh, M.1    Rosenberg, S.A.2
  • 45
    • 0024811638 scopus 로고
    • Overview of interleukin-2 as an im- munotherapeutic agent
    • Chang, A. E., and S. A. Rosenberg. 1989. Overview of interleukin-2 as an im- munotherapeutic agent. Semin. Surg. Oncol. 5: 385-390.
    • (1989) Semin. Surg. Oncol , vol.5 , pp. 385-390
    • Chang, A.E.1    Rosenberg, S.A.2


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