6,7-Dihydroxy-1-oxoisoindoline-4-sulfonamide-containing HIV-1 integrase inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 24, 2012, Pages 7309-7313

  Zhao, Xue Zhi ^a   Maddali, Kasthuraiah ^b   Smith, Steven J ^a   Métifiot, Mathieu ^b   Johnson, Barry C ^a   Marchand, Christophe ^b   Hughes, Stephen H ^a   Pommier, Yves ^b   Burke Jr , Terrence R ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

HIV 1 integrase; Inhibit; Raltegravir; Sulfonamide

Indexed keywords

6,7 DIHYDROXY 1 OXOISOINDOLINE 4 SULFONAMIDE; INTEGRASE; INTEGRASE INHIBITOR; RALTEGRAVIR; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; CYTOTOXICITY; DRUG BINDING; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; IC 50; IN VITRO STUDY; NONHUMAN; SUBSTITUTION REACTION; SUZUKI REACTION;

ACQUIRED IMMUNODEFICIENCY SYNDROME; CELL LINE, TUMOR; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; HIV INTEGRASE; HIV INTEGRASE INHIBITORS; HIV-1; HUMANS; INDOLES; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 84870251845     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.10.088     Document Type: Article

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