Diketoacid-genre HIV-1 integrase inhibitors containing enantiomeric arylamide functionality

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 14, 2009, Pages 5318-5324

  Zhao, Xue Zhi ^a   Maddali, Kasthuraiah ^b   Marchand, Christophe ^b   Pommier, Yves ^b   Burke Jr , Terrence R ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Arylamide; Diketoacid; Enantiomer; HIV 1 integrase; Inhibit

Indexed keywords

2,3 DIHYDRO 6,7 DIHYDROXY 1H ISOINDOL 1 ONE; 4,5 DIHYDROXY 1H ISOINDOLE 1,3(2H) DIONE; AMIDE; INTEGRASE; INTEGRASE INHIBITOR; ISOINDOLE DERIVATIVE; OXOACID; POLYCYCLIC AROMATIC HYDROCARBON DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CHIRALITY; DRUG POTENCY; DRUG SELECTIVITY; ENANTIOMER; IC 50; STEREOSPECIFICITY; STRUCTURE ACTIVITY RELATION;

AMIDES; HIV INTEGRASE; HIV INTEGRASE INHIBITORS; HIV-1; HYDROCARBONS, AROMATIC; PROTEIN BINDING; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 67650022775     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.05.008     Document Type: Article

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