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Volumn 31, Issue 1, 2013, Pages 147-154

Osteoblast and osteocyte-specific loss of Connexin43 results in delayed bone formation and healing during murine fracture healing

Author keywords

bone formation; bone remodeling; connexin 43; fracture healing; mouse model

Indexed keywords

CONNEXIN 43; OSTEOCALCIN; THROMBIN RECEPTOR ACTIVATING PEPTIDE;

EID: 84870250538     PISSN: 07360266     EISSN: 1554527X     Source Type: Journal    
DOI: 10.1002/jor.22178     Document Type: Article
Times cited : (57)

References (43)
  • 1
    • 0034037735 scopus 로고    scopus 로고
    • Gap junctions and biophysical regulation of bone cell differentiation
    • Donahue HJ., 2000. Gap junctions and biophysical regulation of bone cell differentiation. Bone 26: 417-422.
    • (2000) Bone , vol.26 , pp. 417-422
    • Donahue, H.J.1
  • 2
    • 0035298058 scopus 로고    scopus 로고
    • Enhancement of connexin 43 expression increases proliferation and differentiation of an osteoblast-like cell line
    • Gramsch B, Gabriel HD, Wiemann M, et al. 2001. Enhancement of connexin 43 expression increases proliferation and differentiation of an osteoblast-like cell line. Exp Cell Res 264: 397-407.
    • (2001) Exp Cell Res , vol.264 , pp. 397-407
    • Gramsch, B.1    Gabriel, H.D.2    Wiemann, M.3
  • 3
    • 0031857526 scopus 로고    scopus 로고
    • Gap junctional communication modulates gene expression in osteoblastic cells
    • Lecanda F, Towler DA, Ziambaras DA, et al. 1998. Gap junctional communication modulates gene expression in osteoblastic cells. Mol Biol Cell 9: 2249-2258.
    • (1998) Mol Biol Cell , vol.9 , pp. 2249-2258
    • Lecanda, F.1    Towler, D.A.2    Ziambaras, D.A.3
  • 4
    • 0034645070 scopus 로고    scopus 로고
    • Connexin43 deficiency causes delayed ossification, craniofacial abnormalities, and osteoblast dysfunction
    • Lecanda F, Warlow PM, Sheikh S, et al. 2000. Connexin43 deficiency causes delayed ossification, craniofacial abnormalities, and osteoblast dysfunction. J Cell Biol 151: 931-944.
    • (2000) J Cell Biol , vol.151 , pp. 931-944
    • Lecanda, F.1    Warlow, P.M.2    Sheikh, S.3
  • 5
    • 33646422489 scopus 로고    scopus 로고
    • Modulation of connexin43 alters expression of osteoblastic differentiation markers
    • Li Z, Zhou Z, Saunders MM, et al. 2006. Modulation of connexin43 alters expression of osteoblastic differentiation markers. Am J Physiol Cell Physiol 290: C1248-C1255.
    • (2006) Am J Physiol Cell Physiol , vol.290
    • Li, Z.1    Zhou, Z.2    Saunders, M.M.3
  • 6
    • 0037040922 scopus 로고    scopus 로고
    • Transduction of cell survival signals by connexin-43 hemichannels
    • Plotkin LI, Manolagas SC, Bellido T., 2002. Transduction of cell survival signals by connexin-43 hemichannels. J Biol Chem 277: 8648-8657.
    • (2002) J Biol Chem , vol.277 , pp. 8648-8657
    • Plotkin, L.I.1    Manolagas, S.C.2    Bellido, T.3
  • 8
    • 0037385687 scopus 로고    scopus 로고
    • Fluid flow-induced prostaglandin E2 response of osteoblastic ROS 17/2.8 cells is gap junction-mediated and independent of cytosolic calcium
    • Saunders MM, You J, Zhou Z, et al. 2003. Fluid flow-induced prostaglandin E2 response of osteoblastic ROS 17/2.8 cells is gap junction-mediated and independent of cytosolic calcium. Bone 32: 350-356.
    • (2003) Bone , vol.32 , pp. 350-356
    • Saunders, M.M.1    You, J.2    Zhou, Z.3
  • 9
    • 33846284505 scopus 로고    scopus 로고
    • Mechanically stimulated osteocytes regulate osteoblastic activity via gap junctions
    • Taylor AF, Saunders MM, Shingle DL, et al. 2007. Mechanically stimulated osteocytes regulate osteoblastic activity via gap junctions. Am J Physiol Cell Physiol 292: C545-C552.
    • (2007) Am J Physiol Cell Physiol , vol.292
    • Taylor, A.F.1    Saunders, M.M.2    Shingle, D.L.3
  • 10
    • 44449136981 scopus 로고    scopus 로고
    • Attenuated response to in vivo mechanical loading in mice with conditional osteoblast ablation of the connexin43 gene (Gja1)
    • Grimston SK, Brodt MD, Silva MJ, et al. 2008. Attenuated response to in vivo mechanical loading in mice with conditional osteoblast ablation of the connexin43 gene (Gja1). J Bone Miner Res 23: 879-886.
    • (2008) J Bone Miner Res , vol.23 , pp. 879-886
    • Grimston, S.K.1    Brodt, M.D.2    Silva, M.J.3
  • 11
    • 80052297870 scopus 로고    scopus 로고
    • Enhanced osteoclastic resorption and responsiveness to mechanical load in gap junction deficient bone
    • Zhang Y, Paul EM, Sathyendra V, et al. 2011. Enhanced osteoclastic resorption and responsiveness to mechanical load in gap junction deficient bone. PLoS ONE 6: e23516.
    • (2011) PLoS ONE , vol.6
    • Zhang, Y.1    Paul, E.M.2    Sathyendra, V.3
  • 12
    • 33749843058 scopus 로고    scopus 로고
    • Young, adult, and old rats have similar changes in mRNA expression of many skeletal genes after fracture despite delayed healing with age
    • Meyer RA Jr, Desai BR, Heiner DE, et al. 2006. Young, adult, and old rats have similar changes in mRNA expression of many skeletal genes after fracture despite delayed healing with age. J Orthop Res 24: 1933-1944.
    • (2006) J Orthop Res , vol.24 , pp. 1933-1944
    • Meyer, Jr.R.A.1    Desai, B.R.2    Heiner, D.E.3
  • 13
    • 0028907907 scopus 로고
    • Cardiac malformation in neonatal mice lacking connexin43
    • Reaume AG, de Sousa PA, Kulkarni S, et al. 1995. Cardiac malformation in neonatal mice lacking connexin43. Science 267: 1831-1834.
    • (1995) Science , vol.267 , pp. 1831-1834
    • Reaume, A.G.1    De Sousa, P.A.2    Kulkarni, S.3
  • 14
    • 33751168675 scopus 로고    scopus 로고
    • Low peak bone mass and attenuated anabolic response to parathyroid hormone in mice with an osteoblast-specific deletion of connexin43
    • Chung DJ, Castro CH, Watkins M, et al. 2006. Low peak bone mass and attenuated anabolic response to parathyroid hormone in mice with an osteoblast-specific deletion of connexin43. J Cell Sci 119: 4187-4198.
    • (2006) J Cell Sci , vol.119 , pp. 4187-4198
    • Chung, D.J.1    Castro, C.H.2    Watkins, M.3
  • 15
    • 53849108098 scopus 로고    scopus 로고
    • Bone remodeling during fracture repair: The cellular picture
    • Schindeler A, McDonald MM, Bokko P, et al. 2008. Bone remodeling during fracture repair: the cellular picture. Semin Cell Dev Biol 19: 459-466.
    • (2008) Semin Cell Dev Biol , vol.19 , pp. 459-466
    • Schindeler, A.1    McDonald, M.M.2    Bokko, P.3
  • 16
    • 0029082513 scopus 로고
    • Chondrocytes isolated from mature articular cartilage retain the capacity to form functional gap junctions
    • Donahue HJ, Guilak F, Vander Molen MA, et al. 1995. Chondrocytes isolated from mature articular cartilage retain the capacity to form functional gap junctions. J Bone Miner Res 10: 1359-1364.
    • (1995) J Bone Miner Res , vol.10 , pp. 1359-1364
    • Donahue, H.J.1    Guilak, F.2    Vander Molen, M.A.3
  • 17
    • 0033626313 scopus 로고    scopus 로고
    • Interleukin-1beta increases the functional expression of connexin 43 in articular chondrocytes: Evidence for a Ca2+-dependent mechanism
    • Tonon R, D'Andrea P., 2000. Interleukin-1beta increases the functional expression of connexin 43 in articular chondrocytes: evidence for a Ca2+-dependent mechanism. J Bone Miner Res 15: 1669-1677.
    • (2000) J Bone Miner Res , vol.15 , pp. 1669-1677
    • Tonon, R.1    D'Andrea, P.2
  • 18
    • 0036283712 scopus 로고    scopus 로고
    • The functional expression of connexin 43 in articular chondrocytes is increased by interleukin 1beta: Evidence for a Ca2+-dependent mechanism
    • Tonon R, D'Andrea P., 2002. The functional expression of connexin 43 in articular chondrocytes is increased by interleukin 1beta: evidence for a Ca2+-dependent mechanism. Biorheology 39: 153-160.
    • (2002) Biorheology , vol.39 , pp. 153-160
    • Tonon, R.1    D'Andrea, P.2
  • 19
    • 0037453225 scopus 로고    scopus 로고
    • Expression of connexin 43 mRNA in microisolated murine osteoclasts and regulation of bone resorption in vitro by gap junction inhibitors
    • Ransjo M, Sahli J, Lie A., 2003. Expression of connexin 43 mRNA in microisolated murine osteoclasts and regulation of bone resorption in vitro by gap junction inhibitors. Biochem Biophys Res Commun 303: 1179-1185.
    • (2003) Biochem Biophys Res Commun , vol.303 , pp. 1179-1185
    • Ransjo, M.1    Sahli, J.2    Lie, A.3
  • 20
    • 16844379581 scopus 로고    scopus 로고
    • Enhancement of experimental fracture-healing by systemic administration of recombinant human parathyroid hormone (PTH 1-34)
    • Alkhiary YM, Gerstenfeld LC, Krall E, et al. 2005. Enhancement of experimental fracture-healing by systemic administration of recombinant human parathyroid hormone (PTH 1-34). J Bone Joint Surg Am 87: 731-741.
    • (2005) J Bone Joint Surg Am , vol.87 , pp. 731-741
    • Alkhiary, Y.M.1    Gerstenfeld, L.C.2    Krall, E.3
  • 21
    • 0347721834 scopus 로고    scopus 로고
    • Osteoblast-specific knockout of the insulin-like growth factor (IGF) receptor gene reveals an essential role of IGF signaling in bone matrix mineralization
    • Zhang M, Xuan S, Bouxsein ML, et al. 2002. Osteoblast-specific knockout of the insulin-like growth factor (IGF) receptor gene reveals an essential role of IGF signaling in bone matrix mineralization. J Biol Chem 277: 44005-44012.
    • (2002) J Biol Chem , vol.277 , pp. 44005-44012
    • Zhang, M.1    Xuan, S.2    Bouxsein, M.L.3
  • 22
    • 0347126458 scopus 로고    scopus 로고
    • Development of mice with osteoblast-specific connexin43 gene deletion
    • Castro CH, Stains JP, Sheikh S, et al. 2003. Development of mice with osteoblast-specific connexin43 gene deletion. Cell Commun Adhes 10: 445-450.
    • (2003) Cell Commun Adhes , vol.10 , pp. 445-450
    • Castro, C.H.1    Stains, J.P.2    Sheikh, S.3
  • 23
    • 0021612066 scopus 로고
    • Production of a standard closed fracture in laboratory animal bone
    • Bonnarens F, Einhorn TA., 1984. Production of a standard closed fracture in laboratory animal bone. J Orthop Res 2: 97-101.
    • (1984) J Orthop Res , vol.2 , pp. 97-101
    • Bonnarens, F.1    Einhorn, T.A.2
  • 24
    • 0029671373 scopus 로고    scopus 로고
    • Increased expression of TGF-beta 2 in osteoblasts results in an osteoporosis-like phenotype
    • Erlebacher A, Derynck R., 1996. Increased expression of TGF-beta 2 in osteoblasts results in an osteoporosis-like phenotype. J Cell Biol 132: 195-210.
    • (1996) J Cell Biol , vol.132 , pp. 195-210
    • Erlebacher, A.1    Derynck, R.2
  • 25
    • 0027243196 scopus 로고
    • The incidence and size of gap junctions between the bone cells in rat calvaria
    • Jones SJ, Gray C, Sakamaki H, et al. 1993. The incidence and size of gap junctions between the bone cells in rat calvaria. Anat Embryol (Berl) 187: 343-352.
    • (1993) Anat Embryol (Berl) , vol.187 , pp. 343-352
    • Jones, S.J.1    Gray, C.2    Sakamaki, H.3
  • 26
    • 0031184124 scopus 로고    scopus 로고
    • Expression of connexin 43 in rat mandibular bone and periodontal ligament (PDL) cells during experimental tooth movement
    • Su M, Borke JL, Donahue HJ, et al. 1997. Expression of connexin 43 in rat mandibular bone and periodontal ligament (PDL) cells during experimental tooth movement. J Dent Res 76: 1357-1366.
    • (1997) J Dent Res , vol.76 , pp. 1357-1366
    • Su, M.1    Borke, J.L.2    Donahue, H.J.3
  • 27
    • 57149130418 scopus 로고    scopus 로고
    • Gap junctional communication in human osteoclasts in vitro and in vivo
    • Schilling AF, Filke S, Lange T, et al. 2008. Gap junctional communication in human osteoclasts in vitro and in vivo. J Cell Mol Med 12: 2497-2504.
    • (2008) J Cell Mol Med , vol.12 , pp. 2497-2504
    • Schilling, A.F.1    Filke, S.2    Lange, T.3
  • 28
    • 0346845153 scopus 로고    scopus 로고
    • Connexin-mimetic peptide Gap 27 decreases osteoclastic activity
    • Ilvesaro J, Tavi P, Tuukkanen J., 2001. Connexin-mimetic peptide Gap 27 decreases osteoclastic activity. BMC Musculoskelet Disord 2: 10.
    • (2001) BMC Musculoskelet Disord , vol.2 , pp. 10
    • Ilvesaro, J.1    Tavi, P.2    Tuukkanen, J.3
  • 29
    • 0342314454 scopus 로고    scopus 로고
    • Bone-resorbing osteoclasts contain gap-junctional connexin-43
    • Ilvesaro J, Vaananen K, Tuukkanen J., 2000. Bone-resorbing osteoclasts contain gap-junctional connexin-43. J Bone Miner Res 15: 919-926.
    • (2000) J Bone Miner Res , vol.15 , pp. 919-926
    • Ilvesaro, J.1    Vaananen, K.2    Tuukkanen, J.3
  • 30
    • 84856160446 scopus 로고    scopus 로고
    • Cell autonomous requirement of connexin 43 for osteocyte survival: Consequences for endocortical resorption and perisoteal bone formation
    • Bivi N, Condon KW, Allen MR, et al. 2012. Cell autonomous requirement of connexin 43 for osteocyte survival: consequences for endocortical resorption and perisoteal bone formation. J Bone Miner Res 27: 374-389.
    • (2012) J Bone Miner Res , vol.27 , pp. 374-389
    • Bivi, N.1    Condon, K.W.2    Allen, M.R.3
  • 31
    • 79954599783 scopus 로고    scopus 로고
    • Osteoblast connexin43 modulates skeletal architecture by regulating both arms of bone remodeling
    • Watkins M, Grimston SK, Norris JY, et al. 2011. Osteoblast connexin43 modulates skeletal architecture by regulating both arms of bone remodeling. Mol Biol Cell 22: 1240-1251.
    • (2011) Mol Biol Cell , vol.22 , pp. 1240-1251
    • Watkins, M.1    Grimston, S.K.2    Norris, J.Y.3
  • 32
    • 0031734171 scopus 로고    scopus 로고
    • The cell and molecular biology of fracture healing
    • Einhorn TA., 1998. The cell and molecular biology of fracture healing. Clin Orthop Relat Res (355 Suppl): S7-S21.
    • (1998) Clin Orthop Relat Res , Issue.SUPPL. 355
    • Einhorn, T.A.1
  • 33
    • 0034087699 scopus 로고    scopus 로고
    • Role of fracture hematoma and periosteum during fracture healing in rats: Interaction of fracture hematoma and the periosteum in the initial step of the healing process
    • Ozaki A, Tsunoda M, Kinoshita S, et al. 2000. Role of fracture hematoma and periosteum during fracture healing in rats: interaction of fracture hematoma and the periosteum in the initial step of the healing process. J Orthop Sci 5: 64-70.
    • (2000) J Orthop Sci , vol.5 , pp. 64-70
    • Ozaki, A.1    Tsunoda, M.2    Kinoshita, S.3
  • 34
    • 77957197146 scopus 로고    scopus 로고
    • Long bone fracture repair in mice harboring GFP reporters for cells within the osteoblastic lineage
    • Ushiku C, Adams DJ, Jiang X, et al. 2010. Long bone fracture repair in mice harboring GFP reporters for cells within the osteoblastic lineage. J Orthop Res 28: 1338-1347.
    • (2010) J Orthop Res , vol.28 , pp. 1338-1347
    • Ushiku, C.1    Adams, D.J.2    Jiang, X.3
  • 35
    • 0027937391 scopus 로고
    • Localization of the mRNA for bone matrix proteins during fracture healing as determined by in situ hybridization
    • Hirakawa K, Hirota S, Ikeda T, et al. 1994. Localization of the mRNA for bone matrix proteins during fracture healing as determined by in situ hybridization. J Bone Miner Res 9: 1551-1557.
    • (1994) J Bone Miner Res , vol.9 , pp. 1551-1557
    • Hirakawa, K.1    Hirota, S.2    Ikeda, T.3
  • 36
    • 77649187986 scopus 로고    scopus 로고
    • Immunolocalization of BMPs, BMP antagonists, receptors, and effectors during fracture repair
    • Yu YY, Lieu YY, Lu C, et al. 2010. Immunolocalization of BMPs, BMP antagonists, receptors, and effectors during fracture repair. Bone 46: 841-851.
    • (2010) Bone , vol.46 , pp. 841-851
    • Yu, Y.Y.1    Lieu, Y.Y.2    Lu, C.3
  • 37
    • 0033816428 scopus 로고    scopus 로고
    • Association of enhanced expression of gap junctions with in vitro chondrogenic differentiation of rat nasal septal cartilage-released cells following their dedifferentiation and redifferentiation
    • Loty S, Foll C, Forest N, et al. 2000. Association of enhanced expression of gap junctions with in vitro chondrogenic differentiation of rat nasal septal cartilage-released cells following their dedifferentiation and redifferentiation. Arch Oral Biol 45: 843-856.
    • (2000) Arch Oral Biol , vol.45 , pp. 843-856
    • Loty, S.1    Foll, C.2    Forest, N.3
  • 38
    • 0036836664 scopus 로고    scopus 로고
    • Bone morphogenetic protein-2 modulation of chondrogenic differentiation in vitro involves gap junction-mediated intercellular communication
    • Zhang W, Green C, Stott NS., 2002. Bone morphogenetic protein-2 modulation of chondrogenic differentiation in vitro involves gap junction-mediated intercellular communication. J Cell Physiol 193: 233-243.
    • (2002) J Cell Physiol , vol.193 , pp. 233-243
    • Zhang, W.1    Green, C.2    Stott, N.S.3
  • 40
    • 0031032220 scopus 로고    scopus 로고
    • Quantitative assessment of experimental fracture repair by peripheral computed tomography
    • Augat P, Merk J, Genant HK, et al. 1997. Quantitative assessment of experimental fracture repair by peripheral computed tomography. Calcif Tissue Int 60: 194-199.
    • (1997) Calcif Tissue Int , vol.60 , pp. 194-199
    • Augat, P.1    Merk, J.2    Genant, H.K.3
  • 41
    • 0032955858 scopus 로고    scopus 로고
    • Callus formation and fixation rigidity: A fracture model in rats
    • Probst A, Jansen H, Ladas A, et al. 1999. Callus formation and fixation rigidity: a fracture model in rats. J Orthop Res 17: 256-260.
    • (1999) J Orthop Res , vol.17 , pp. 256-260
    • Probst, A.1    Jansen, H.2    Ladas, A.3
  • 43
    • 0029015765 scopus 로고
    • Cell-to-cell communication in osteoblastic networks: Cell line-dependent hormonal regulation of gap junction function
    • Donahue HJ, McLeod KJ, Rubin CT, et al. 1995. Cell-to-cell communication in osteoblastic networks: cell line-dependent hormonal regulation of gap junction function. J Bone Miner Res 10: 881-889.
    • (1995) J Bone Miner Res , vol.10 , pp. 881-889
    • Donahue, H.J.1    McLeod, K.J.2    Rubin, C.T.3


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