Biomechanics of Fracture Healing

Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism: Seventh Edition

Volumn , Issue , 2009, Pages 65-69

  Morgan, Elise F ^a,b   Einhorn, Thomas A ^b  

^a BOSTON UNIVERSITY   (United States)

^b BOSTON UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84863495702     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9780470623992.ch12     Document Type: Chapter

References (48)

1. Chao EYS, Aro HT 1997 Biomechanics of fracture fixation. In: Mow VC, Hayes WC (eds.) Basic Orthopaedic Biomechanics. Lippincott-Raven, Philadelphia, PA, USA, pp. 317-352.
2. Foux A, Black RC, Uhthoff HK 1990 Quantitative measures for fracture healing: An in-vitro biomechanical study. J Biomech Eng 112:401-406.
3. Tsiridis E, Morgan EF, Bancroft JM, Song M, Kain M, Gerstenfeld L, Einhorn TA, Bouxsein ML, Tornetta P III 2007 Effects of OP-1 and PTH in a new experimental model for the study of metaphyseal bone healing. J Orthop Res 25:1193-1203.
4. Ulrich-Vinther M, Andreassen TT 2005 Osleoprotegerin treatment impairs remodeling and apparent material properties of callus tissue without influencing structural fracture strength. Calcif Tissue Int 76:280-286.
5. Leong PL, Morgan EF 2008 Measurement of fracture callus material properties via nanoindentation. Acta Biomaterialia 4:1569-1575.
6. White AA III, Panjabi MM, Southwick WO 1977 The four biomechanical stages of fracture repair. J Bone Joint Surg Am 59:188-192.
7. Alkhiary YM, Gerstenfeld LC, Krall E, Sato M, Westmore M, Mitlak B, Einhorn TA 2004 Parathyroid Hormone (1-24; Teri-paritide) Enhances Experimental Fracture Healing. Orthopaedic Research Society, San Francisco, CA, USA.
8. Andreassen TT, Ejersted C, Oxlund H 1999 Intermittent parathyroid hormone (1-34) treatment increases callus formation and mechanical strength of healing rat fractures. J Bone Miner Res 14:960-968.
9. Kakar S, Einhorn TA, Vora S, Miara LJ, Hon G, Wigner NA, Toben D, Jacobsen KA, Al-Sebaei MO, Song M, Trackman PC, Morgan EF, Gerstenfeld LC, Barnes GL 2007 Enhanced Chon-drogenesis and Wnt-signaling in Parathyroid Hormone Treated Fractures. J Bone Miner Res 22:1903-1912.
10. Amanat N, McDonald M, Godfrey C, Bilston L, Little D 2007 Optimal timing of a single dose of zoledronic acid to increase strength in rat fracture repair. J Bone Miner Res 22:867-876.
11. Little DG, McDonald M, Bransford R, Godfrey CB, Amanat N 2005 Manipulation of the anabolic and catabolic responses with OP-1 and zoledronic acid in a rat critical defect model. J Bone Miner Res 20:2044-2052.
12. Richardson JB, Cunningham JL, Goodship AE, O'Connor BT, Kenwright J 1994 Measuring stiffness can define healing of tibial fractures. J Bone Joint Surg Br 76:389-394.
13. Hentc R, Cordcy J, Perren SM 2003 In vivo measurement of bending stiffness in fracture healing. Biomed Eng Online 2:8.
14. Ogrodnik PJ, Moorcroft CI, Thomas PB 2001 A fracture movement monitoring system to aid in the assessment of fracture healing in humans. Proc Inst Mech Eng [H] 215:405-414.
15. Aarnes GT, Steen H, Ludvigsen P, Waanders NA, Huiskes R, Goldstein SA 2005 In vivo assessment of regenerate axial stiffness in distraction osteogenesis. J Orthop Res 23:494-498.
16. Watanabe Y, Takai S, Arai Y, Yoshino N, Hirasawa Y 2001 Prediction of mechanical properties of healing fractures using acoustic emission. J Orthop Res 19:548-553.
17. Gerlanc M, Haddad D, Hyatt GW, Langloh JT, St Hilaire P 1975 Ultrasonic study of normal and fractured bone. Clin Orthop Relat Res 111:175-180.
18. Glinkowski W. Gorecki A 2006 Clinical experiences with ultra-sonometric measurement of fracture healing. Technol Health Care 14:321-333.
19. Brown SA. Mayor MB 1976 Ultrasonic assessment of early callus formation. Biomed Eng 11:124-127,136.
20. Jamsa T, Koivukangas A, Kippo K, Hannuniemi R, Jalovaara P, Tuukkanen J 2000 Comparison of radiographic and pQCT analyses of healing rat tibial fractures. Calcif Tissue Int 66:288-291.
21. Augat P, Merk J, Genant HK, Claes L 1997 Quantitative assessment of experimental fracture repair by peripheral computed tomography. Calcif Tissue Int 60:194-199.
22. den Boer FC, Bramer JA, Patka P, Bakker FC, Barentsen RH, Feilzer AJ, de Lange ES, Haarman HJ 1998 Quantification of fracture healing with three-dimensional computed tomography. Arch Orthop Trauma Surg 117:345-350.
23. Grigoryan M, Lynch JA, Fierlinger AL, Guermazi A, Fan B, MacLean DB, MacLean A, Genant HK 2003 Quantitative and qualitative assessment of closed fracture healing using computed tomography and conventional radiography. Acad Radiol 10:1267-1273.
24. Kuhlman JE, Fishman EK, Magid D, Scott WW Jr, Brooker AF, Siegelman SS 1988 Fracture nonunion: CT assessment with multiplanar reconstruction. Radiology 167:483-488.
25. Shefelbine SJ, Simon U, Claes L, Gold A, Gäbet Y, Bab I, Muller R, Augat P 2005 Prediction of fracture callus mechanical properties using micro-CT images and voxel-based finite element analysis. Bone 36:480-488.
26. Augat P, Merk J, Wolf S, Claes L 2001 Mechanical stimulation by external application of cyclic tensile strains does not effectively enhance bone healing. J Orthop Trauma 15:54-60.
27. Schell H, Epari DR, Kassi JP, Bragulla H, Bail HJ, Duda GN 2005 The course of bone healing is influenced by the initial shear fixation stability. J Orthop Res 23:1022-1028.
28. Bishop NE, van Rhijn M, Tami I, Corveleijn R, Schneider E, Ito K 2006 Shear does not necessarily inhibit bone healing. Clin Orthop Relat Res 443:307-314.
29. Park SH, O'Connor K, McKellop H, Sarmiento A 1998 The influence of active shear or compressive motion on fracture-healing. J Bone Joint Surg Am 80:868-878.
30. Wolf S, Augat P, Eckert-Hubner K, Laule A, Krischak GD, Claes LE 2001 Effects of high-frequency, low-magnitude mechanical stimulus on bone healing. Clin Orthop 385:192-198.
31. Goodship AE, Cunningham JL, Kenwright J 1998 Strain rate and timing of stimulation in mechanical modulation of fracture healing. Clin Orthop 355(Suppl):S105-S115.
32. Claes L, Augat P, Suger G, Wilke HJ 1997 Influence of size and stability of the osteotomy gap on the success of fracture healing. J Orthop Res 15:577-584.
33. Claes L, Eckert-Hubner K, Augat P 2002 The effect of mechanical stability on local vascularization and tissue differentiation in callus healing. J Orthop Res 20:1099-1105.
34. Goodship AE, Kenwright J 1985 The influence of induced micro-movement upon the healing of experimental tibial fractures. J Bone Joint Surg Br 67:650-655.
35. Claes LE, Wilke HJ, Augat P, Rubenacker S, Margevicius KJ 1995 Effect of dynamization on gap healing of diaphyseal fractures under external fixation. Clin Biomech (Bristol. Avon) 10:227-234.
36. Goodship AE, Watkins PE, Rigby HS, Kenwright J 1993 The role of fixator frame stiffness in the control of fracture healing. An experimental study. J Biomech 26:1027-1035.
37. Augat P, Margevicius K, Simon J, Wolf S, Suger G, Claes L 1998 Local tissue properties in bone healing: Influence of size and stability of the osteotomy gap. J Orthop Res 16:475-481.
38. Claes LE. Heigele CA, Neidlinger-Wilke C, Kaspar D, Seidl W, Margevicius KJ, Augat P 1998 Effects of mechanical factors on the fracture healing process. Clin Orthop 355(Suppl):S132-S147.
39. Augat P, Burger J, Schorlemmer S, Henke T, Peraus M, Claes L 2003 Shear movement at the fracture site delays healing in a diaphyseal fracture model. J Orthop Res 21:1011-1017.
40. Cullinane DM, Fredrick A, Eisenberg SR. Pacicca D, Elman MV, Lee C, Salisbury K, Gerstenfeld LC, Einhorn TA 2002 Induction of a neoarthrosis by precisely controlled motion in an experimental mid-femoral defect. J Orthop Res 20:579-586.
41. Cullinane DM, Salisbury KT, Alkhiary Y, Eisenberg S, Gerstenfeld L, Einhorn TA 2003 Effects of the local mechanical environment on vertebrate tissue differentiation during repair: Does repair recapitulate development? J Exp Biol 206:2459-2471.
42. Perren SM 1979 Physical and biological aspecs of fracture healing with special reference to internal fixation. Clin Orthop 138:175-180.
43. Perren SM, Cordey J 1980 The concept of interfragmentary strain. In: Uhthoff HK (ed.) Current Concepts of Internal Fixation of Fractures. Springer, Berlin, Germany, pp. 63-77.
44. Carter DR, Beaupre GS, Giori NJ, Helms JA 1998 Mechanobiol-ogy of skeletal regeneration. Clin Orthop 355(Suppl):S41-S55.
45. Claes LE, Heigele CA 1999 Magnitudes of local stress and strain along bony surfaces predict the course and type of fracture healing. J Biomech 32:255-266.
46. Lacroix D, Prendergast PJ 2002 A mechano-regulation model for tissue differentiation during fracture healing: Analysis of gap size and loading. J Biomech 35:1163-1171.
47. Prendergast PJ, Huiskes R, Soballe K 1997 ESB Research Award 1996. Biophysical stimuli on cells during tissue differentiation at implant interfaces. J Biomech 30:539-548.
48. Isaksson H, Wilson W, van Donkelaar CC, Huiskes R, Ito K 2006 Comparison of biophysical stimuli for mechano-regulation of tissue differentiation during fracture healing. J Biomech 39:15071516.