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Volumn 19, Issue 6, 2012, Pages 465-469

Protease-activated receptor-1 antagonists: Focus on SCH 530348

Author keywords

antithrombotic agents; protease activated receptor; Thrombin

Indexed keywords

ACETYLSALICYLIC ACID; ANTITHROMBOCYTIC AGENT; ATOPAXAR; HEPARIN; PROTEINASE ACTIVATED RECEPTOR 1; THROMBIN RECEPTOR ANTAGONIST; TICLOPIDINE; VORAPAXAR;

EID: 84870243949     PISSN: 10752765     EISSN: 15363686     Source Type: Journal    
DOI: 10.1097/MJT.0b013e3181ff7c16     Document Type: Review
Times cited : (3)

References (38)
  • 1
    • 58649085872 scopus 로고    scopus 로고
    • Role of platelets in atherothrombosis
    • Jennings LK. Role of platelets in atherothrombosis. Am J Cardiol. 2009;103:A4-A10.
    • (2009) Am J Cardiol , vol.103
    • Jennings, L.K.1
  • 2
    • 50649123533 scopus 로고    scopus 로고
    • Time course of events in acute coronary syndromes: Implications for clinical practice from the GRACE registry
    • Fox KA, Anderson FA, Jr, Goodman SG, et al. Time course of events in acute coronary syndromes: implications for clinical practice from the GRACE registry. Nat Clin Pract Cardiovasc Med. 2008;5:580-589.
    • (2008) Nat Clin Pract Cardiovasc Med , vol.5 , pp. 580-589
    • Fox, K.A.1    Anderson, F.A.2    Goodman Jr., S.G.3
  • 3
    • 43749117048 scopus 로고    scopus 로고
    • Early and Late Benefits of Prasugrel in Patients With Acute Coronary Syndromes Undergoing Percutaneous Coronary Intervention. A TRITON-TIMI 38 (TRial to Assess Improvement in Therapeutic Outcomes by Optimizing Platelet InhibitioN with Prasugrel-Thrombolysis In Myocardial Infarction) Analysis
    • DOI 10.1016/j.jacc.2008.04.002, PII S0735109708012709
    • Antman EM,Wiviott SD, Murphy SA, et al. Early and late benefits of prasugrel in patients with acute coronary syndromes undergoing percutaneous coronary intervention: a TRITON-TIMI 38 (TRial to Assess Improvement in Therapeutic Outcomes by Optimizing Platelet InhibitioN with Prasugrel- Thrombolysis in Myocardial Infarction) analysis. J Am Coll Cardiol. 2008;51:2028-2033. (Pubitemid 351689056)
    • (2008) Journal of the American College of Cardiology , vol.51 , Issue.21 , pp. 2028-2033
    • Antman, E.M.1    Wiviott, S.D.2    Murphy, S.A.3    Voitk, J.4    Hasin, Y.5    Widimsky, P.6    Chandna, H.7    Macias, W.8    McCabe, C.H.9    Braunwald, E.10
  • 5
    • 36349012420 scopus 로고    scopus 로고
    • Intrinsic pathway of coagulation and arterial thrombosis
    • DOI 10.1161/ATVBAHA.107.155952
    • Gailani D, Renne T. Intrinsic pathway of coagulation and arterial thrombosis. Arterioscler Thromb Vasc Biol. 2007;27: 2507-2513. (Pubitemid 350158899)
    • (2007) Arteriosclerosis, Thrombosis, and Vascular Biology , vol.27 , Issue.12 , pp. 2507-2513
    • Gailani, D.1    Renne, T.2
  • 6
    • 33748495552 scopus 로고    scopus 로고
    • Protease-activated receptors in cardiovascular diseases
    • DOI 10.1161/CIRCULATIONAHA.105.574830, PII 0000301720060905000014
    • LegerAJ, Covic L, KuliopulosA. Protease-activated receptors in cardiovascular diseases. Circulation. 2006;114:1070-1077. (Pubitemid 44358884)
    • (2006) Circulation , vol.114 , Issue.10 , pp. 1070-1077
    • Leger, A.J.1    Covic, L.2    Kuliopulos, A.3
  • 7
    • 2142651737 scopus 로고    scopus 로고
    • Role of protease-activated receptors in the vascular system
    • Hirano K, KanaideH. Role of protease-activated receptors in the vascular system. J Atheroscler Thromb. 2003;10:211-225.
    • (2003) J Atheroscler Thromb , vol.10 , pp. 211-225
    • Hirano, K.1    Kanaide, H.2
  • 8
    • 1642279517 scopus 로고    scopus 로고
    • Protease-activated receptors: Contribution to physiology and disease
    • DOI 10.1152/physrev.00028.2003
    • Ossovskaya VS, Bunnett NW. Protease-activated receptors: contribution to physiology and disease. Physiol Rev. 2004;84:579-621. (Pubitemid 38365493)
    • (2004) Physiological Reviews , vol.84 , Issue.2 , pp. 579-621
    • Ossovskaya, V.S.1    Bunnett, N.W.2
  • 13
    • 0027374144 scopus 로고
    • Receptor mechanism of thrombin-induced endothelium-dependent and endothelium-independent coronary vascular effects in dogs
    • Ku DD, Zaleski JK. Receptor mechanism of thrombin-induced endothelium-dependent and endothelium-independent coronary vascular effects in dogs. J Cardiovasc Pharmacol. 1993;22: 609-616. (Pubitemid 23286758)
    • (1993) Journal of Cardiovascular Pharmacology , vol.22 , Issue.4 , pp. 609-616
    • Ku, D.D.1    Zaleski, J.K.2
  • 17
    • 77955775700 scopus 로고    scopus 로고
    • Proteaseactivated receptor 1 antagonists prevent platelet aggregation and adhesion without affecting thrombin time
    • Nadal-Wollbold F, Bocquet A, Bourbon T, et al. Proteaseactivated receptor 1 antagonists prevent platelet aggregation and adhesion without affecting thrombin time. Eur J Pharmacol. 2010;644:188-194.
    • (2010) Eur J Pharmacol , vol.644 , pp. 188-194
    • Nadal-Wollbold, F.1    Bocquet, A.2    Bourbon, T.3
  • 19
    • 61849180442 scopus 로고    scopus 로고
    • Safety and tolerability of SCH 530348 in patients undergoing nonurgent percutaneous coronary intervention: A randomised, double-blind, placebo controlled phase II study
    • Becker RC, Moliterno DJ, Jennings LK, et al. Safety and tolerability of SCH 530348 in patients undergoing nonurgent percutaneous coronary intervention: a randomised, double-blind, placebo controlled phase II study. Lancet. 2009;373:919-928.
    • (2009) Lancet , vol.373 , pp. 919-928
    • Becker, R.C.1    Moliterno, D.J.2    Jennings, L.K.3
  • 20
    • 58149156653 scopus 로고    scopus 로고
    • Optimizing dose of the novel thrombin receptor antagonist SCH530348 based on pharmacodynamics and pharmacokinetics in healthy subjects
    • Kosoglou T, Reyderman L, Kasserra C, et al. Optimizing dose of the novel thrombin receptor antagonist SCH530348 based on pharmacodynamics and pharmacokinetics in healthy subjects. Clin Pharmacol Ther. 2008;83(Suppl 1):S55.
    • (2008) Clin Pharmacol Ther , vol.83 , Issue.SUPPL. 1
    • Kosoglou, T.1    Reyderman, L.2    Kasserra, C.3
  • 21
    • 0035899289 scopus 로고    scopus 로고
    • Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-segment elevation
    • DOI 10.1056/NEJMoa010746
    • YusufS,ZhaoF,MehtaSR,etal.Effectsofclopidogrel inaddition to aspirin in patients with acute coronary syndromes without ST-segment elevation.NEngl JMed. 2001;345:494-502. (Pubitemid 32758501)
    • (2001) New England Journal of Medicine , vol.345 , Issue.7 , pp. 494-502
    • Yusuf, S.1    Zhao, F.2    Mehta, S.R.3    Chrolavicius, S.4    Tognoni, G.5    Fox, K.K.6
  • 24
    • 0036846734 scopus 로고    scopus 로고
    • Clopidogrel does not suppress blood markers of coagulation activation in aspirin-treated patients with non-ST-elevation acute coronary syndromes
    • DOI 10.1053/euhj.2000.3234
    • Eikelboom JW, Weitz JI, Budaj A, et al. Clopidogrel does not suppress blood markers of coagulation activation in aspirin-treated patients with non-ST-elevation acute coronary syndromes. Eur Heart J. 2002;23:1771-1779. (Pubitemid 35334270)
    • (2002) European Heart Journal , vol.23 , Issue.22 , pp. 1771-1779
    • Eikelboom, J.W.1    Weitz, J.I.2    Budaj, A.3    Zhao, F.4    Copland, I.5    Maciejewski, P.6    Johnston, M.7    Yusuf, S.8
  • 25
    • 21644448736 scopus 로고    scopus 로고
    • 12 antagonist, with clopidogrel in percutaneous coronary intervention: Results of the Joint Utilization of Medications to Block Platelets Optimally (JUMBO)-TIMI 26 trial
    • DOI 10.1161/CIRCULATIONAHA.104.502815
    • Wiviott SD, Antman EM, Winters KJ, et al. Randomized comparison of prasugrel (CS-747, LY640315), a novel thienopyridine P2Y12 antagonist, with clopidogrel in percutaneous coronary intervention: results of the Joint Utilization of Medications to Block Platelets Optimally (JUMBO)-TIMI 26 trial. Circulation. 2005; 111:3366-3373. (Pubitemid 40931949)
    • (2005) Circulation , vol.111 , Issue.25 , pp. 3366-3373
    • Wiviott, S.D.1    Antman, E.M.2    Winters, K.J.3    Weerakkody, G.4    Murphy, S.A.5    Behounek, B.D.6    Carney, R.J.7    Lazzam, C.8    McKay, R.G.9    McCabe, C.H.10    Braunwald, E.11
  • 26
    • 77649207578 scopus 로고    scopus 로고
    • Safety and exploratory efficacy of the novel thrombin receptor (PAR-1) antagonist SCH530348 for non-ST-segment elevation acute coronary syndrome
    • Goto S, Yamaguchi T, Ikeda Y, et al. Safety and exploratory efficacy of the novel thrombin receptor (PAR-1) antagonist SCH530348 for non-ST-segment elevation acute coronary syndrome. J Atheroscler Thromb. 2010;17:156-164.
    • (2010) J Atheroscler Thromb , vol.17 , pp. 156-164
    • Goto, S.1    Yamaguchi, T.2    Ikeda, Y.3
  • 27
    • 69549132169 scopus 로고    scopus 로고
    • A phase II safety study of novel antiplatelet agent, SCH530348, in japanese ptients with prior ischaemic stroke
    • Shinohara Y, Goto S, Shimizu K, et al. A phase II safety study of novel antiplatelet agent, SCH530348, in japanese ptients with prior ischaemic stroke. Int J Stroke. 2008(Suppl 3):139.
    • (2008) Int J Stroke , Issue.SUPPL. 3 , pp. 139
    • Shinohara, Y.1    Goto, S.2    Shimizu, K.3
  • 28
    • 85058720552 scopus 로고    scopus 로고
    • The Thrombin Receptor Antagonist for Clinical Event Reduction in Acute Coronary Syndrome (TRA*CER) trial: Study design and rationale
    • TRA*CER Executive and Steering Committees e4
    • TRA*CER Executive and Steering Committees. The Thrombin Receptor Antagonist for Clinical Event Reduction in Acute Coronary Syndrome (TRA*CER) trial: study design and rationale. Am Heart J. 2009;158: 327-334.e4.
    • (2009) Am Heart J , vol.158 , pp. 327-334
  • 29
    • 68949156886 scopus 로고    scopus 로고
    • Evaluation of a novel antiplatelet agent for secondary prevention in patients with a history of atherosclerotic disease: Design and rationale for the Thrombin-Receptor Antagonist in Secondary Prevention of Atherothrombotic Ischemic Events (TRA 2 degrees P)-TIMI 50 trial
    • e3
    • Morrow DA, Scirica BM, Fox KA, et al. Evaluation of a novel antiplatelet agent for secondary prevention in patients with a history of atherosclerotic disease: design and rationale for the Thrombin-Receptor Antagonist in Secondary Prevention of Atherothrombotic Ischemic Events (TRA 2 degrees P)-TIMI 50 trial. Am Heart J. 2009;158:335-341.e3.
    • (2009) Am Heart J , vol.158 , pp. 335-341
    • Morrow, D.A.1    Scirica, B.M.2    Fox, K.A.3
  • 30
    • 70349306707 scopus 로고    scopus 로고
    • Dabigatran versus warfarin in patients with atrial fibrillation
    • Connolly SJ, Ezekowitz MD, Yusuf S, et al. Dabigatran versus warfarin in patients with atrial fibrillation. N Engl J Med. 2009;361:1139-1151.
    • (2009) N Engl J Med , vol.361 , pp. 1139-1151
    • Connolly, S.J.1    Ezekowitz, M.D.2    Yusuf, S.3
  • 31
    • 33749642654 scopus 로고    scopus 로고
    • Direct vascular effects of protease-activated receptor type 1 agonism in vivo in humans
    • DOI 10.1161/CIRCULATIONAHA.106.638478, PII 0000301720061010000013
    • Gudmundsdottir IJ,Megson IL, Kell JS, et al. Direct vascular effects of protease-activated receptor type 1 agonism in vivo in humans. Circulation. 2006;114:1625-1632. (Pubitemid 44547433)
    • (2006) Circulation , vol.114 , Issue.15 , pp. 1625-1632
    • Gudmundsdottir, I.J.1    Megson, I.L.2    Kell, J.S.3    Ludlam, C.A.4    Fox, K.A.A.5    Webb, D.J.6    Newby, D.E.7
  • 33
    • 77955219114 scopus 로고    scopus 로고
    • Mechanism of action and clinical development of platelet thrombin receptor antagonists
    • Ueno M, Ferreiro JL, Angiolillo DJ. Mechanism of action and clinical development of platelet thrombin receptor antagonists. Expert Rev Cardiovasc Ther. 2010;8:1191-1200.
    • (2010) Expert Rev Cardiovasc Ther , vol.8 , pp. 1191-1200
    • Ueno, M.1    Ferreiro, J.L.2    Angiolillo, D.J.3
  • 34
    • 78149355554 scopus 로고    scopus 로고
    • Double-blind, placebo-controlled Phase II studies of the proteaseactivated receptor 1 antagonist E5555 (atopaxar) in Japanese patients with acute coronary syndrome or highrisk coronary artery disease
    • Goto S, Ogawa H, Takeuchi M, et al. Double-blind, placebo-controlled Phase II studies of the proteaseactivated receptor 1 antagonist E5555 (atopaxar) in Japanese patients with acute coronary syndrome or highrisk coronary artery disease. Eur Heart J. 2010;31:2601-2613.
    • (2010) Eur Heart J , vol.31 , pp. 2601-2613
    • Goto, S.1    Ogawa, H.2    Takeuchi, M.3
  • 35
    • 77956600237 scopus 로고    scopus 로고
    • Thrombin receptor antagonists for the treatment of atherothrombosis: Therapeutic potential of vorapaxar and e-5555
    • Leonardi S, Tricoci P, Becker RC. Thrombin receptor antagonists for the treatment of atherothrombosis: therapeutic potential of vorapaxar and e-5555. Drugs. 2010;70:1771-1783.
    • (2010) Drugs , vol.70 , pp. 1771-1783
    • Leonardi, S.1    Tricoci, P.2    Becker, R.C.3
  • 36
    • 77649099693 scopus 로고    scopus 로고
    • Differential expression of protease-activated receptors in monocytes from patients with primary antiphospholipid syndrome
    • Lopez-Pedrera C, Aguirre MA, Buendia P, et al. Differential expression of protease-activated receptors in monocytes from patients with primary antiphospholipid syndrome. Arthritis Rheum.2010;62:869-877.
    • (2010) Arthritis Rheum , vol.62 , pp. 869-877
    • Lopez-Pedrera, C.1    Aguirre, M.A.2    Buendia, P.3
  • 37
    • 77249091781 scopus 로고    scopus 로고
    • Thrombin activation of proteinase-activated receptor 1 potentiates the myofilament Ca2+ sensitivity and induces vasoconstriction in porcine pulmonary arteries
    • Maki J, Hirano M, Hoka S, et al. Thrombin activation of proteinase-activated receptor 1 potentiates the myofilament Ca2+ sensitivity and induces vasoconstriction in porcine pulmonary arteries. Br J Pharmacol. 2010;159: 919-927.
    • (2010) Br J Pharmacol , vol.159 , pp. 919-927
    • Maki, J.1    Hirano, M.2    Hoka, S.3
  • 38
    • 74949088005 scopus 로고    scopus 로고
    • Inhibition of thrombin action ameliorates insulin resistance in type 2 diabetic db/db mice
    • Mihara M, Aihara K, Ikeda Y, et al. Inhibition of thrombin action ameliorates insulin resistance in type 2 diabetic db/db mice. Endocrinology. 2010;151:513-519.
    • (2010) Endocrinology , vol.151 , pp. 513-519
    • Mihara, M.1    Aihara, K.2    Ikeda, Y.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.