Thrombin activation of proteinase-activated receptor 1 potentiates the myofilament Ca 2+ sensitivity and induces vasoconstriction in porcine pulmonary arteries

British Journal of Pharmacology

Volumn 159, Issue 4, 2010, Pages 919-927

  Maki, Jun ^a   Hirano, Mayumi ^a   Hoka, Sumio ^a   Kanaide, Hideo ^b   Hirano, Katsuya ^a  

^a KYUSHU UNIVERSITY   (Japan)

^b INTERNATIONAL UNIVERSITY OF HEALTH AND WELFARE   (Japan)

Author keywords

Ca 2+ sensitivity; Myosin light chain phosphorylation; Proteinase activated receptor 1; Pulmonary artery; Thrombin; Vasoconstriction

Indexed keywords

4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; ALPHA TOXIN; CALCIUM ION; MYOSIN LIGHT CHAIN; POTASSIUM ION; PROTEINASE ACTIVATED RECEPTOR 1; PROTEINASE INHIBITOR; THROMBIN;

ANIMAL TISSUE; ARTICLE; CALCIUM SIGNALING; CONTROLLED STUDY; DEPOLARIZATION; MYOFILAMENT; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PULMONARY ARTERY; SMOOTH MUSCLE CONTRACTILITY; SWINE; TENSION; VASOCONSTRICTION;

ANIMALS; CALCIUM SIGNALING; CATTLE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIUM, VASCULAR; MEMBRANE POTENTIALS; MICROFILAMENTS; MUSCLE, SMOOTH, VASCULAR; MYOSIN LIGHT CHAINS; PHOSPHORYLATION; POTASSIUM; PROTEASE INHIBITORS; PROTEIN KINASE INHIBITORS; PULMONARY ARTERY; RECEPTOR, PAR-1; RHO-ASSOCIATED KINASES; SWINE; THROMBIN; VASOCONSTRICTION; VASODILATION;

EID: 77249091781     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2009.00591.x     Document Type: Article

References (36)

1. Alexander SP, Mathie A, Peters JA (2008). Guide to Receptors and Channels (GRAC), 3rd edition. Br J Pharmacol 153 (Suppl. 2 S1 S209.
2. Bjornsson J, Edwards WD (1985). Primary pulmonary hypertension: a histopathologic study of 80 cases. Mayo Clin Proc 60 : 16 25.
3. Blackhart BD, Ruslim-Litrus L, Lu CC, Alves VL, Teng W, Scarborough RM et al 2000). Extracellular mutations of protease-activated receptor-1 result in differential activation by thrombin and thrombin receptor agonist peptide. Mol Pharmacol 58 : 1178 1187.
4. Brenner O (1935). Pathology of the vessels of the pulmonary circulation. Arch Intern Med 56 : 211 237.
5. Bretschneider E, Paintz M, Glusa E (1995). Inositol 1,4,5-triphosphate and protein kinase C are involved in thrombin- and trap-induced vascular smooth muscle contraction. Agents Actions 45 : 309 313.
6. Coughlin SR (2000). Thrombin signalling and protease-activated receptors. Nature 407 : 258 264.
7. Dartevelle P, Fadel E, Mussot S, Chapelier A, Herve P, de Perrot M et al 2004). Chronic thromboembolic pulmonary hypertension. Eur Respir J 23 : 637 648.
8. Derkach DN, Ihara E, Hirano K, Nishimura J, Takahashi S, Kanaide H (2000). Thrombin causes endothelium-dependent biphasic regulation of vascular tone in the porcine renal interlobar artery. Br J Pharmacol 131 : 1635 1642.
9. Farber HW, Loscalzo J (2004). Pulmonary arterial hypertension. New Engl J Med 351 : 1655 1665.
10. Fukunaga R, Hirano K, Hirano M, Niiro N, Nishimura J, Maehara Y et al 2006). Upregulation of proteinase-activated receptors and hypercontractile responses precede development of arterial lesions after balloon injury. Am J Physiol Heart Circ Physiol 291 : H2388 H2395.
11. Glusa E, Paintz M (1994). Relaxant and contractile responses of porcine pulmonary arteries to a thrombin receptor activating peptide (TRAP). Naunyn Schmiedebergs Arch Pharmacol 349 : 431 436.
12. Glusa E, Bretschneider E, Paintz M (1994). Contractile effects of thrombin in porcine pulmonary arteries and the influence of thrombin inhibitors. Naunyn Schmiedebergs Arch Pharmacol 349 : 101 106. (Pubitemid 24045028)
13. Godin D, Rioux F, Marceau F, Drapeau G (1995). Mode of action of thrombin in the rabbit aorta. Br J Pharmacol 115 : 903 908.
14. Hamilton JR, Moffatt JD, Frauman AG, Cocks TM (2001). Protease-activated receptor (PAR) 1 but not PAR2 or PAR4 mediates endothelium-dependent relaxation to thrombin and trypsin in human pulmonary arteries. J Cardiovasc Pharmacol 38 : 108 119.
15. 2+ sensitization of the contractile apparatus in vascular smooth muscle. J Pharmacol Sci 104 : 109 115.
16. Hirano K (2007b). The roles of proteinase-activated receptors in the vascular physiology and pathophysiology. Arterioscler Thromb Vasc Biol 27 : 27 36.
17. Hirano K, Kanaide H (2003). Role of protease-activated receptors in the vascular system. J Atheroscler Thromb 10 : 211 225.
18. Hirano K, Kanaide H, Nakamura M (1989). Effects of okadaic acid on cytosolic calcium concentrations and on contractions of the porcine coronary artery. Br J Pharmacol 98 : 1261 1266.
19. Hollenberg MD, Compton SJ (2002). International Union of Pharmacology. XXVIII. Proteinase-activated receptors. Pharmacol Rev 54 : 203 217.
20. Johnson SR, Granton JT, Mehta S (2006a). Thrombotic arteriopathy and anticoagulation in pulmonary hypertension. Chest 130 : 545 552. (Pubitemid 44267025)
21. Johnson SR, Mehta S, Granton JT (2006b). Anticoagulation in pulmonary arterial hypertension: a qualitative systematic review. Eur Respir J 28 : 999 1004.
22. Kai Y, Hirano K, Maeda Y, Nishimura J, Sasaki T, Kanaide H (2007). Prevention of the hypercontractile response to thrombin by proteinase-activated receptor-1 antagonist in subarachnoid hemorrhage. Stroke 38 : 3259 3265.
23. i in smooth muscle strips using front-surface fluorimetry. Methods Mol Biol 312 : 251 259.
24. Ku DD, Dai J (1997). Expression of thrombin receptors in human atherosclerotic coronary arteries leads to an exaggerated vasoconstrictory response in vitro. J Cardiovasc Pharmacol 30 : 649 657.
25. Ku DD, Zaleski JK (1993). Receptor mechanism of thrombin-induced endothelium-dependent and endothelium-independent coronary vascular effects in dogs. J Cardiovasc Pharmacol 22 : 609 616.
26. Macfarlane SR, Seatter MJ, Kanke T, Hunter GD, Plevin R (2001). Proteinase-activated receptors. Pharmacol Rev 53 : 245 282.
27. McLaughlin JN, Patterson MM, Malik AB (2007). Protease-activated receptor-3 (PAR3) regulates PAR1 signaling by receptor dimerization. Proc Natl Acad Sci USA 104 : 5662 5667.
28. Muramatsu I, Laniyonu A, Moore GJ, Hollenberg MD (1992). Vascular actions of thrombin receptor peptide. Can J Physiol Pharmacol 70 : 996 1003.
29. Nelken NA, Soifer SJ, O'Keefe J, Vu TK, Charo IF, Coughlin SR (1992). Thrombin receptor expression in normal and atherosclerotic human arteries. J Clin Invest 90 : 1614 1621.
30. 2+ sensitivity in -toxin permeabilized arterial smooth muscle. Biochem Biophys Res Commun 157 : 677 683.
31. Persechini A, Kamm KE, Stull JT (1986). Different phosphorylated forms of myosin in contracting tracheal smooth muscle. J Biol Chem 261 : 6293 6299.
32. Ramachandran R, Hollenberg MD (2008). Proteinases and signalling: pathophysiological and therapeutic implications via PARs and more. Br J Pharmacol 153 (Suppl. 1 S263 S282.
33. 2+-induced tension development in chemically skinned smooth muscle fibers. J Gen Physiol 72 : 1 14.
34. Sakihara C, Nishimura J, Kobayashi S, Takahashi S, Kanaide H (1996). Direct inhibitory effect of chlorpromazine on smooth muscle of the porcine pulmonary artery. Anesthesiology 85 : 616 625.
35. 2+ sensitivity of smooth muscle and nonmuscle myosin II: modulated by G proteins, kinases, and myosin phosphatase. Physiol Rev 83 : 1325 1358.
36. 2+ sensitivity of porcine renal artery. J Physiol 516 : 55 65.