Protease-activated receptor 1 antagonists prevent platelet aggregation and adhesion without affecting thrombin time

European Journal of Pharmacology

Volumn 644, Issue 1-3, 2010, Pages 188-194

  Nadal Wollbold, Florence ^a   Bocquet, Arnaud ^a   Bourbon, Thierry ^a   Létienne, Robert ^a   Le Grand, Bruno ^a  

^a INSTITUT DE RECHERCHE PIERRE FABRE   (France)

Author keywords

Adhesion; Aggregation; PAR1 antagonist; Platelet; Thrombin time

Indexed keywords

2 [2 (3,5 DITERT BUTYL 4 HYDROXYPHENYL) 2 OXOETHYL] 6 ETHOXY 3 IMINO N METHYLISOINDOLINE 5 CARBOXAMIDE; AMINO ACID; ANTICOAGULANT AGENT; ER 121958; HEMATOLOGIC AGENT; N3 CYCLOPROPYL 7 (4 ISOPROPYLBENZYL N3 METHYL 7H PYRROLO [3.2 F]QUINAZOLINE 1.3 DIAMINE); POLYPEPTIDE; PROTEINASE ACTIVATED RECEPTOR 1; SCH 203099; SERYLPHENYLALANYLLEUCYLLEUCYLARGININE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTICOAGULATION; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; GUINEA PIG; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; MALE; NONHUMAN; PRIORITY JOURNAL; SPECIES COMPARISON; THROMBIN TIME; THROMBOCYTE ADHESION; THROMBOCYTE AGGREGATION INHIBITION;

ANIMALS; GUINEA PIGS; HUMANS; INHIBITORY CONCENTRATION 50; ISOINDOLES; MALE; MODELS, ANIMAL; PLATELET ADHESIVENESS; PLATELET AGGREGATION; PLATELET AGGREGATION INHIBITORS; PYRROLES; QUINAZOLINES; RECEPTOR, PAR-1; SPECIES SPECIFICITY; THROMBIN TIME;

EID: 77955775700     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2010.07.013     Document Type: Article

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