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Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 24, 2012, Pages 7297-7301

Discovery and characterization of a novel 7-aminopyrazolo[1,5-a]pyrimidine analog as a potent hepatitis C virus inhibitor

(21) Hwang, Jong Yeon a Windisch, Marc Peter b Jo, Suyeon a Kim, Keumhyun b Kong, Sunju b Kim, Hyoung Cheul a Kim, Soohyun b Kim, Heeyoung b Lee, Myung Eun b Kim, Youngmi b Choi, Jihyun a Park, Dong Sik a Park, Eunjung a Kwon, Jeongjin a Nam, Jiyoun b Ahn, Sujin b Cechetto, Jonathan b Kim, Junwon a Liuzzi, Michel b No, Zaesung b Lee, Jinhwa b more..

a Institute Pasteur Korea (South Korea)

b Institut Pasteur Korea (South Korea)

Author keywords

7 Aminopyrazolopyrimidine; Hepatitis C virus; Infectious cell culture system; Phenotypic high throughput screening

Indexed keywords

7 AMINOPYRAZOLO[1,5 A]PYRIMIDINE DERIVATIVE; ANTIVIRUS AGENT; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; CELL CULTURE; CELL GROWTH; CYTOTOXICITY; DOSE RESPONSE; DRUG HALF LIFE; DRUG STABILITY; DRUG STRUCTURE; DRUG SYNTHESIS; GROWTH INHIBITION; HEPATITIS C VIRUS; HUMAN; NONHUMAN; POLYMERIZATION; RAT; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

ANIMALS; ANTIVIRAL AGENTS; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DISCOVERY; DRUG EVALUATION, PRECLINICAL; DRUG STABILITY; HEPACIVIRUS; HUMANS; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; PYRAZOLES; PYRIMIDINES; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

HEPATITIS C VIRUS;

EID: 84870238340 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2012.10.123 Document Type: Article

Times cited : (62)

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