Discovery and optimization of a series of 2-aminothiazole-oxazoles as potent phosphoinositide 3-kinase γ inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 24, 2012, Pages 7534-7538

  Oka, Yusuke ^a   Yabuuchi, Tetsuya ^a   Fujii, Yasuyuki ^a   Ohtake, Hidenori ^a   Wakahara, Shunichi ^a   Matsumoto, Kayo ^a   Endo, Mayumi ^a   Tamura, Yunoshin ^a   Sekiguchi, Yoshinori ^a  

^a TAISHO PHARMACEUTICAL CO LTD   (Japan)

Author keywords

2 Aminothiazole oxazoles; Phosphoinositide 3 kinase; PI3K inhibitor

Indexed keywords

2 AMINOOXAZOLE DERIVATIVE; PHOSPHATIDYLINOSITOL 3 KINASE GAMMA; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR;

ARTICLE; CHEMICAL MODIFICATION; DRUG BINDING; DRUG DESIGN; DRUG SYNTHESIS; ENZYME INHIBITION; HIGH THROUGHPUT SCREENING; IC 50; STRUCTURE ACTIVITY RELATION;

ANIMALS; CLASS IB PHOSPHATIDYLINOSITOL 3-KINASE; CRYSTALLOGRAPHY, X-RAY; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DISCOVERY; HIGH-THROUGHPUT SCREENING ASSAYS; MACROPHAGES; MICE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; OXAZOLES; PROTEIN KINASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES;

EID: 84870237102     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.10.028     Document Type: Article

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