Beta amyloid-induced depression of hippocampal long-term potentiation is mediated through the amylin receptor

Journal of Neuroscience

Volumn 32, Issue 48, 2012, Pages 17401-17406

  Kimura, Ryoichi ^a,b   MacTavish, David ^b   Yang, Jing ^c   Westaway, David ^b,c   Jhamandas, Jack H ^b  

^a HYOGO COLLEGE OF MEDICINE   (Japan)

^b UNIVERSITY OF ALBERTA   (Canada)

^c UNIVERSITY OF ALBERTA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

AC 253; AMYLIN; AMYLIN RECEPTOR; AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ELECTROPHYSIOLOGY; ELECTROSTIMULATION; EXCITATORY POSTSYNAPTIC POTENTIAL; FEMALE; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; LONG TERM DEPRESSION; LONG TERM POTENTIATION; MALE; MOUSE; NERVE CELL PLASTICITY; NONHUMAN; PRIORITY JOURNAL; SYNAPTIC TRANSMISSION; TRANSGENIC MOUSE;

AMYLOID BETA-PEPTIDES; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; ELECTRIC STIMULATION; EXCITATORY POSTSYNAPTIC POTENTIALS; FEMALE; HIPPOCAMPUS; ISLET AMYLOID POLYPEPTIDE; LONG-TERM POTENTIATION; MALE; MICE; MICE, TRANSGENIC; PEPTIDE FRAGMENTS; RECEPTORS, ISLET AMYLOID POLYPEPTIDE;

EID: 84870171588     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.3028-12.2012     Document Type: Article

References (23)

1. Andreetto E, Yan LM, Tatarek-Nossol M, Velkova A, Frank R, Kapurniotu A (2010) Identification of hot regions of the Aβ-IAPP interaction interface as high-affinity binding sites in both cross- and self-association. Angew Chem Int Ed Engl 49:3081-3085.
2. Arrieta-Cruz I, Wang J, Pavlides C, Pasinetti GM (2010) Carvedilol reestablishes long-term potentiation in a mouse model of Alzheimer's disease. J Alzheimers Dis 21:649-654.
3. Bellucci A, Luccarini I, Scali C, Prosperi C, Giovannini MG, Pepeu G, Casa-menti F (2006) Cholinergic dysfunction, neuronal damage and axonal loss in TgCRND8 mice. Neurobiol Dis 23:260-272.
4. Butler PC, Chou J, Carter WB, Wang YN, Bu BH, Chang D, Chang JK, Rizza RA (1990) Effects of meal ingestion on plasma amylin concentration in NIDDM and nondiabetic humans. Diabetes 39:752-756.
5. Chapman PF, White GL, Jones MW, Cooper-Blacketer D, Marshall VJ, Irizarry M, Younkin L, Good MA, Bliss TV, Hyman BT, Younkin SG, Hsiao KK (1999) Impaired synaptic plasticity and learning in aged amyloid precursor protein transgenic mice. Nat Neurosci 2:271-276.
6. Chin JH, Ma L, MacTavish D, Jhamandas JH (2007) Amyloid /3 protein modulates glutamate-mediated neurotransmission in the rat basal fore-brain: Involvement of presynaptic neuronal nicotinic acetylcholine and metabotropic glutamate receptors. J Neurosci 27:9262-9269.
7. Chishti MA, Yang DS, Janus C, Phinney AL, Horne P, Pearson J, Strome R, Zuker N, Loukides J, French J, Turner S, Lozza G, Grilli M, Kunicki S, Morissette C, Paquette J, Gervais F, Bergeron C, Fraser PE, Carlson GA, et al. (2001) Early-onset amyloid deposition and cognitive deficits in transgenic mice expressing a double mutant form of amyloid precursor protein. J Biol Chem 276:21562-21570.
8. Cooper GJ, Willis AC, Clark A, Turner RC, Sim RB, Reid KB (1987) Purification and characterization of a peptide from amyloid-rich pancreases of type 2 diabetic patients. Proc Natl Acad Sci USA 84:8628-8632.
9. Fu W, Ruangkittisakul A, MacTavish D, Shi JY, Ballanyi K, Jhamandas JH (2012) Amyloid beta (Aβ) peptide directly activates Amylin-3 receptor subtype by triggering multiple intracellular signalling pathways. J Biol Chem 287:18820-18830.
10. Huang Y, Mucke L (2012) Alzheimer mechanisms and therapeutic strategies. Cell 148:1204-1222.
11. Jhamandas JH, MacTavish D (2004) Antagonist of the amylin receptor blocks jS-amyloid toxicity in rat cholinergic basal forebrain neurons. J Neurosci 24:5579-5584.
12. Jhamandas JH, Li Z, Westaway D, Yang J, Jassar S, MacTavish D (2011) Actions of jS-amyloid protein on human neurons are expressed through the amylin receptor. Am J Pathol 178:140-149.
13. Kimura R, Ohno M (2009) Impairments in remote memory stabilization precede hippocampal synaptic and cognitive failures in 5XFAD Alzheimer mouse model. Neurobiol Dis 33:229-235.
14. Klyubin I, Walsh DM, Lemere CA, Cullen WK, Shankar GM, Betts V, Spooner ET, Jiang L, Anwyl R, Selkoe DJ, Rowan MJ (2005) Amyloid beta protein immunotherapy neutralizes Abeta oligomers that disrupt synaptic plasticity in vivo. Nat Med 11:556-561.
15. Patel AN, Jhamandas JH (2012) Neuronal receptors as targets for the action of amyloid-beta protein (Aβ) in the brain. Expert Rev Mol Med 14:1-19.
16. Paxinos G, Chai SY, Christopoulos G, Huang XF, Toga AW, Wang HQ, Sexton PM (2004) In vitro autoradiographic localization of calcitonin and amylin binding sites in monkey brain. J Chem Neuroanat 27:217-236.
17. Rowan MJ, Klyubin I, Cullen WK, Anwyl R (2003) Synaptic plasticity in animal models of early Alzheimer's disease. Philos Trans R Soc Lond B 358:821-828.
18. Selkoe DJ (2008) Soluble oligomers of the amyloid beta-protein impair synaptic plasticity and behavior. Behav Brain Res 92:106-113.
19. Sexton PM, Paxinos G, Kenney MA, Wookey PJ, Beaumont K (1994) In vitro autoradiographic localization of amylin binding sites in rat brain. Neuroscience 62:553-567.
20. Stine WB Jr, Dahlgren KN, Krafft GA, LaDu MJ (2003) In vitro characterization of conditions for amyloid-beta peptide oligomerization and fibril-logenesis. J Biol Chem 278:11612-11622.
21. Townsend M, Qu Y, Gray A, Wu Z, Seto T, Hutton M, Shearman MS, Middle-ton RE (2010) Oral treatment with a y-secretase inhibitor improves long-term potentiation in a mouse model of Alzheimer's disease. J Pharmacol Exp Ther 333:110-119.
22. Walsh DM, Klyubin I, Fadeeva JV, Cullen WK, Anwyl R, Wolfe MS, Rowan MJ, Selkoe DJ (2002) Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo. Nature 416:535-539.
23. Wilcox KC, Lacor PN, Pitt J, Klein WL (2011) Aβ oligomer-induced synapse degeneration in Alzheimer's disease. Cell Mol Neurobiol 31:939-948.