Influence of thiostrepton binding on the ribosomal GTPase associated region characterized by molecular dynamics simulation

Bioorganic and Medicinal Chemistry

Volumn 20, Issue 24, 2012, Pages 7194-7205

  Wolf, Antje ^a,b   Baumann, Sascha ^c,d   Arndt, Hans Dieter ^c,e   Kirschner, Karl N ^a  

^a FRAUNHOFER INSTITUTE FOR ALGORITHMS AND SCIENTIFIC COMPUTING SCAI   (Germany)

^b UNIVERSITY OF BONN   (Germany)

^c MAX PLANCK INSTITUTE OF MOLECULAR PHYSIOLOGY   (Germany)

^d TU DORTMUND UNIVERSITY   (Germany)

^e FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

Author keywords

Dynamics; GTPase associated region (GAR); Protein and RNA interface; Ribosome; Thiopeptide

Indexed keywords

GUANOSINE TRIPHOSPHATASE; RIBOSOME RNA; THIOSTREPTON;

ALPHA HELIX; AMINO TERMINAL SEQUENCE; ARTICLE; BINDING SITE; CIRCULAR DICHROISM; CONTROLLED STUDY; DRUG DESIGN; DRUG RECEPTOR BINDING; DRUG STRUCTURE; LIGAND BINDING; MOLECULAR DYNAMICS; NONHUMAN; PRINCIPAL COMPONENT ANALYSIS; PROTEIN CONFORMATION; PROTEIN PROTEIN INTERACTION; PROTEIN RNA BINDING; PROTEIN SECONDARY STRUCTURE; PROTEIN SYNTHESIS INHIBITION; RIBOSOME; STOICHIOMETRY; THERMUS THERMOPHILUS;

ANTI-BACTERIAL AGENTS; GTP PHOSPHOHYDROLASES; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; RIBOSOMAL PROTEINS; RIBOSOMES; RNA, RIBOSOMAL; THIOSTREPTON;

BACTERIA (MICROORGANISMS);

EID: 84870065030     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2012.09.025     Document Type: Article

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