MRI biosensor for protein kinase A encoded by a single synthetic gene

Magnetic Resonance in Medicine

Volumn 68, Issue 6, 2012, Pages 1919-1923

  Airan, Raag D ^a   Bar Shir, Amnon ^a   Liu, Guanshu ^a,b   Pelled, Galit ^a,b   McMahon, Michael T ^a,b   Van Zijl, Peter C M ^a,b   Bulte, Jeff W M ^a,b   Gilad, Assaf A ^a,b  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b KENNEDY KRIEGER INSTITUTE   (United States)

Author keywords

biosensor; chemical exchange saturation transfer; protein kinase A; reporter gene

Indexed keywords

BIOSENSORS; GENE ENCODING; MAGNETIC RESONANCE IMAGING; PHOSPHORYLATION; REAL TIME SYSTEMS;

CELLULAR POPULATIONS; CHEMICAL EXCHANGE SATURATION TRANSFER; COMPLEX BIOLOGICAL SYSTEMS; HIGH SPATIAL RESOLUTION; PRECLINICAL DEVELOPMENT; PROTEIN KINASE A; RECOGNITION SEQUENCE; REPORTER GENE;

ENZYMES;

CYCLIC AMP DEPENDENT PROTEIN KINASE; SYNTHETIC DNA;

AMINO ACID SEQUENCE; ARTICLE; BIOSENSOR; ESCHERICHIA COLI; GENETIC CODE; MOLECULAR IMAGING; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PHOSPHORYLATION; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TANDEM REPEAT;

EID: 84870064437     PISSN: 07403194     EISSN: 15222594     Source Type: Journal    
DOI: 10.1002/mrm.24483     Document Type: Article

References (37)

1. Noble ME, Endicott JA, Johnson LN,. Protein kinase inhibitors: insights into drug design from structure. Science 2004; 303: 1800-1805.
2. Manning G, Whyte DB, Martinez R, Hunter T, Sudarsanam S,. The protein kinase complement of the human genome. Science 2002; 298: 1912-1934.
3. Walsh DA, Perkins JP, Krebs EG,. An adenosine 3',5'-monophosphate- dependant protein kinase from rabbit skeletal muscle. J Biol Chem 1968; 243: 3763-3765.
4. Murray AJ,. Pharmacological PKA inhibition: all may not be what it seems. Sci Signal 2008; 1: re4.
5. Kemp BE, Graves DJ, Benjamini E, Krebs EG,. Role of multiple basic residues in determining the substrate specificity of cyclic AMP-dependent protein kinase. J Biol Chem 1977; 252: 4888-4894.
6. Zhang J, Ma Y, Taylor SS, Tsien RY,. Genetically encoded reporters of protein kinase A activity reveal impact of substrate tethering. Proc Natl Acad Sci USA 2001; 98: 14997-15002.
7. Ni Q, Ganesan A, Aye-Han NN, Gao X, Allen MD, Levchenko A, Zhang J,. Signaling diversity of PKA achieved via a Ca2+-cAMP-PKA oscillatory circuit. Nat Chem Biol 2011; 7: 34-40.
8. Gilad AA, McMahon MT, Walczak P, Winnard PT, Jr, Raman V, van Laarhoven HW, Skoglund CM, Bulte JW, van Zijl PC,. Artificial reporter gene providing MRI contrast based on proton exchange. Nat Biotechnol 2007; 25: 217-219.
9. Liu G, Liang Y, Bar-Shir A, et al. Monitoring enzyme activity using a diamagnetic chemical exchange saturation transfer magnetic resonance imaging contrast agent. J Am Chem Soc 2011; 133: 16326-16329.
10. Ward KM, Aletras AH, Balaban RS,. A new class of contrast agents for MRI based on proton chemical exchange dependent saturation transfer (CEST). J Magn Reson 2000; 143: 79-87.
11. Sherry AD, Woods M,. Chemical exchange saturation transfer contrast agents for magnetic resonance imaging. Annu Rev Biomed Eng 2008; 10: 391-411.
12. van Zijl PC, Yadav NN,. Chemical exchange saturation transfer (CEST): what is in a name and what isn't? Magn Reson Med 2011; 65: 927-948.
13. Li AX, Wojciechowski F, Suchy M, Jones CK, Hudson RH, Menon RS, Bartha R,. A sensitive PARACEST contrast agent for temperature MRI: Eu3+-DOTAM-glycine (Gly)-phenylalanine (Phe). Magn Reson Med 2008; 59: 374-381.
14. Wu Y, Soesbe TC, Kiefer GE, Zhao P, Sherry AD,. A responsive europium(III) chelate that provides a direct readout of pH by MRI. J Am Chem Soc 2010; 132: 14002-14003.
15. Yoo B, Pagel MD,. A PARACEST MRI contrast agent to detect enzyme activity. J Am Chem Soc 2006; 128: 14032-14033.
16. Trokowski R, Ren J, Kalman FK, Sherry AD,. Selective sensing of zinc ions with a PARACEST contrast agent. Angew Chem Int Ed Engl 2005; 44: 6920-6923.
17. van Zijl PC, Jones CK, Ren J, Malloy CR, Sherry AD,. MRI detection of glycogen in vivo by using chemical exchange saturation transfer imaging (glycoCEST). Proc Natl Acad Sci USA 2007; 104: 4359-4364.
18. Ling W, Regatte RR, Navon G, Jerschow A,. Assessment of glycosaminoglycan concentration in vivo by chemical exchange-dependent saturation transfer (gagCEST). Proc Natl Acad Sci USA 2008; 105: 2266-2270.
19. Cai K, Haris M, Singh A, Kogan F, Greenberg JH, Hariharan H, Detre JA, Reddy R,. Magnetic resonance imaging of glutamate. Nat Med 2012; 18: 302-306.
20. Delli Castelli D, Dastru W, Terreno E, Cittadino E, Mainini F, Torres E, Spadaro M, Aime S,. In vivo MRI multicontrast kinetic analysis of the uptake and intracellular trafficking of paramagnetically labeled liposomes. J Control Release 2010; 144: 271-279.
21. Choi J, Kim K, Kim T, Liu G, Bar-Shir A, Hyeon T, McMahon MT, Bulte JW, Fisher JP, Gilad AA,. Multimodal imaging of sustained drug release from 3-D poly(propylene fumarate) (PPF) scaffolds. J Control Release 2011; 156: 239-245.
22. Vinogradov E, He H, Lubag A, Balschi JA, Sherry AD, Lenkinski RE,. MRI detection of paramagnetic chemical exchange effects in mice kidneys in vivo. Magn Reson Med 2007; 58: 650-655.
23. Liu G, Gilad AA, Bulte JW, van Zijl PC, McMahon MT,. High-throughput screening of chemical exchange saturation transfer MR contrast agents. Contrast Media Mol Imaging 2010; 5: 162-170.
24. Kim M, Gillen J, Landman BA, Zhou J, van Zijl PC,. Water saturation shift referencing (WASSR) for chemical exchange saturation transfer (CEST) experiments. Magn Reson Med 2009; 61: 1441-1450.
25. Koretsky AP, Brosnan MJ, Chen LH, Chen JD, Van Dyke T,. NMR detection of creatine kinase expressed in liver of transgenic mice: determination of free ADP levels. Proc Natl Acad Sci USA 1990; 87: 3112-3116.
26. Walter G, Barton ER, Sweeney HL,. Noninvasive measurement of gene expression in skeletal muscle. Proc Natl Acad Sci USA 2000; 97: 5151-5155.
27. Shapiro MG, Szablowski JO, Langer R, Jasanoff A,. Protein nanoparticles engineered to sense kinase activity in MRI. J Am Chem Soc 2009; 131: 2484-2486.
28. Shapiro MG, Westmeyer GG, Romero PA, Szablowski JO, Kuster B, Shah A, Otey CR, Langer R, Arnold FH, Jasanoff A,. Directed evolution of a magnetic resonance imaging contrast agent for noninvasive imaging of dopamine. Nat Biotechnol 2010; 28: 264-270.
29. Iordanova B, Ahrens ET,. In vivo magnetic resonance imaging of ferritin-based reporter visualizes native neuroblast migration. Neuroimage 2012; 59: 1004-1012.
30. Cohen B, Ziv K, Plaks V, Israely T, Kalchenko V, Harmelin A, Benjamin LE, Neeman M,. MRI detection of transcriptional regulation of gene expression in transgenic mice. Nat Med 2007; 13: 498-503.
31. Bartelle BB, Berrios-Otero CA, Rodriguez JJ, Friedland AE, Aristizabal O, Turnbull DH,. Novel genetic approach for in vivo vascular imaging in mice. Circ Res 2012; 110: 938-947.
32. McMahon MT, Gilad AA, DeLiso MA, Berman SM, Bulte JW, van Zijl PC,. New "multicolor" polypeptide diamagnetic chemical exchange saturation transfer (DIACEST) contrast agents for MRI. Magn Reson Med 2008; 60: 803-812.
33. Jones CK, Polders D, Hua J, Zhu H, Hoogduin HJ, Zhou J, Luijten P, van Zijl PC,. In vivo three-dimensional whole-brain pulsed steady-state chemical exchange saturation transfer at 7 T. Magn Reson Med 2012; 67: 1579-1589.
34. Liu G, Moake M, Har-el Y-E, et al. In vivo multicolor molecular MR imaging using diamagnetic chemical exchange saturation transfer liposomes. Magn Reson Med 2012; 67: 1106-1113.
35. Singh A, Cai K, Haris M, Hariharan H, Reddy R,. On B(1) inhomogeneity correction of in vivo human brain glutamate chemical exchange saturation transfer contrast at 7T. Magn Reson Med 2012. doi: 10.1002/mrm.24290.
36. Violin JD, Zhang J, Tsien RY, Newton AC,. A genetically encoded fluorescent reporter reveals oscillatory phosphorylation by protein kinase C. J Cell Biol 2003; 161: 899-909.
37. Kondo N, Nishimura S,. MALDI-TOF mass-spectrometry-based versatile method for the characterization of protein kinases. Chemistry 2009; 15: 1413-1421.