MRI detection of paramagnetic chemical exchange effects in mice kidneys in vivo

Magnetic Resonance in Medicine

Volumn 58, Issue 4, 2007, Pages 650-655

  Vinogradov, Elena ^a,d   He, Huamei ^a   Lubag, Angelo ^b   Baischi, James A ^a   Sherry, A Dean ^b,c   Lenkinski, Robert E ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c UNIVERSITY OF TEXAS AT DALLAS   (United States)

^d BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

Contrast; Exchange; Low B1 WALTZ 16; OPARACHEE; PARACEST

Indexed keywords

CHEMICAL DETECTION; ION EXCHANGE; MAMMALS; PARAMAGNETISM;

CHEMICAL EXCHANGE EFFECT; CONTRAST; CONTRAST EFFECTS; LOW B1 WALTZ-16; OPARACHEE; PARACEST; STOCK SOLUTIONS; WATER SIGNALS;

SIGNAL TO NOISE RATIO;

AMERICIUM; CHEMICAL EXCHANGE SATURATION TRANSFER AGENT; GADOLINIUM; LANTHANIDE; NUCLEAR MAGNETIC RESONANCE IMAGING AGENT; PARACEST AGENT; TECHNETIUM 1,4,7,10 TETRAAZACYCLODODECANE 1,4,7,10 TETRAACETIC ACID; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BOLUS INJECTION; CONTRAST ENHANCEMENT; DRUG ACCUMULATION; DRUG CLEARANCE; FEMALE; IMAGE ANALYSIS; KIDNEY CLEARANCE; KIDNEY PAPILLA; MALE; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; SIGNAL NOISE RATIO; SPECTROMETER;

EID: 35048855940     PISSN: 07403194     EISSN: 15222594     Source Type: Journal    
DOI: 10.1002/mrm.21393     Document Type: Article

References (30)

1. Carr D, Brown J, Bydder G, Steiner R, Weinmann H, Speck U, Hall A, Young I. Gadolinium-DTPA as a contrast agent in MRI: initial clinical experience in 20 patients. Am J Roentgenol 1984;143:215-224.
2. Aime S, Castelli DD, Terreno E. Highly sensitive MRI chemical exchange saturation agents using liposomes. Angew Chem Int Ed 2005; 44:5513-5515.
3. Querol M, Bogdanov AJ. Amplification strategies in MR imaging: activation and accumulation of sensing contrast agents (SCAs). J Magn Reson Imaging 2006;24:971-982.
4. Modo M, Hoehn M, Bulte JWM. Cellular MR imaging. Mol Imaging 2005;4:143-164.
5. Navon G, Shinar H, Eliav U, Seo Y. Multiquantum filters and order in tissues. NMR Biomed 2001;14:112-132.
6. Michaeli S, Sorce DJ, Idiyatullin D, Ugurbil K, Garwood M. Transverse relaxation in the rotating frame induced by chemical exchange. J Magn Reson 2004;169:293-299.
7. Moran PR. A flow zeugmatographic interlace for NMR imaging in humans. Magn Reson Imaging 1982;1:197-203.
8. Ward K, Alertas AH, Balaban RS. A new class of contrast agents for MRI based on proton chemical exchange dependent saturation transfer (CEST). J Magn Reson 2000;143:79-87.
9. Ward K, Balaban RS. Determination of pH using water protons and chemical exchange-dependent saturation transfer (CEST). Magn Reson Med 2000;44:799-802.
10. Zhou J, van Zijl PCM. Chemical exchange saturation transfer imaging and spectroscopy. Prog Nucl Magn Reson Spectrosc 2006;48:109-136.
11. Zhou J, Payen J-F, Wilson DA, Traystman RJ, van Zijl PCM. Using the amide proton signals of intracellular propteins and peptides to detect pH effects in MRI. Nat Med 2003;9:1085-1090.
12. Jones CK, Ren J, Malloy C, Sherry AD, van Zijl PCM. MRI detection of glycogen (GlycoCEST). In: Proceedings of the 14th Annual Meeting of ISMRM, Seattle, WA, 2006. p 482.
13. Gilad AA, McMahon MT, Walczak P, Winnard PT Jr, Raman V, Bulte JW, van Zijl PCM. Artificial reporter gene providing MRI contrast in-vivo based on chemical exchange. In: Proceedings of the 14th Annual Meeting of ISMRM, Seattle, WA, 2006. p 23.
14. Jones CK, Schlosser MJ, van Zijl PCM, Pomper MG, Golay X, Zhou JY. Amide proton transfer imaging of human brain tumors at 3T. Magn Reson Med 2006;56:585-592.
15. McConnell HM. Reaction rates by nuclear magnetic resonance. J Chem Phys 1961;35:41-48.
16. Snoussi K, Bulte JW, Gueron M, van Zijl PCM. Sensitive CEST agents based on nucleic acid imino proton exchange: detection of Poly(rU) and a dendrimer-Poly(rU) model for nucleic acid delivery and pharmacology. Magn Reson Med 2003;49:998-1005.
17. Zhang S, Sherry AD. Physical characteristics of lanthanide complexes that act as magnetization transfer (MT) contrast agents. J Solid State Chem 2003;171:38-43.
18. Zhang S, Winter P, Wu K, Sherry AD. A novel europium(III)-based MRI contrast agent. J Am Chem Soc 2001;123:1517-1518.
19. Aime S, Barge A, Castelli DD, Fedeli F, Mortillaro A, Nielsen FU, Terreno E. Paramagnetic lanthanide(III) complexes as pH-sensitive chemical exchange saturation transfer (CEST) contrast agents for MRI applications. Magn Reson Med 2002;47:639-648.
20. Aime S, Castelli DD, Fedeli F, Terreno E. A paramagnetic MRI-CEST agent responsive to lactate concentration. J Am Chem Soc 2002;124:9364-9365.
21. Zhang S, Malloy C, Sherry AD. MRI thermometry based on PARACEST agents. J Am Chem Soc 2005;127:17572-17573.
22. Zhang S, Trokowski R, Sherry AD. A paramagnetic CEST agent for imaging glucose by MRI. J Am Chem Soc 2003;125:15288-15289.
23. Liu G, Pagel MD. A smart PARACEST MRI contrast agent for nitric oxide detection. In: Proceedings of the 14th Annual Meeting of ISMRM, Seattle, WA, 2006. p 370.
24. Rosenblum R, Pagel MD. A "smart" PARACEST agent for detection of transglutominase activity. In: Proceedings of the 14th Annual Meeting of ISMRM, Seattle, WA, 2006. p 370.
25. Trokowski R, Ren J, Kaiman FK, Sherry AD. Selective sensing of zinc ions with PARACEST contrast agent. Angew Chem Int Ed 2005;44:6920-6923.
26. Lenkinski RE. Lanthanide complexes of peptides and proteins. Biol MR 1984;6:23-71.
27. Woessner DE, Zhang S, Merrit M, Sherry AD. A numerical solution of the Bloch equations provides insights into the optimal design of PARACEST agents. Magn Reson Med 2005;53:790-799.
28. Vinogradov E, Zhang S, Lubag A, Balschi JA, Sherry AD, Lenkinski RE. On resonance low B1 pulses for imaging of the effects of PARACEST agents. J Magn Reson 2005;176:54-63.
29. Shaka AJ, Keeler J, Frenkiel T, Freeman R. An improved sequence for broadband decoupling; WALTZ-16. J Magn Reson 1983;52:335-338.
30. Zhang S, Merrit M, Woessner DE, Lenkinski RE, Sherry AD. PARACEST agents: modulating MRI contrast via water proton exchange. Acc Chem Res 2003;36:783-790.