Directed evolution of a magnetic resonance imaging contrast agent for noninvasive imaging of dopamine

Nature Biotechnology

Volumn 28, Issue 3, 2010, Pages 264-270

  Shapiro, Mikhail G ^a   Westmeyer, Gil G ^b   Romero, Philip A ^c   Szablowski, Jerzy O ^a   Küster, Benedict ^b   Shah, Ameer ^a   Otey, Christopher R ^c   Langer, Robert ^a   Arnold, Frances H ^c   Jasanoff, Alan ^a,b  

^a Massachusetts Institute of Technology Cambridge   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^c California Institute of Technology   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ABSORBANCES; CYTOCHROME P450; DIRECTED EVOLUTION; DISSOCIATION CONSTANT; FUNCTIONAL MRI; HEME DOMAIN; IN-VIVO IMAGING; LIGAND BINDING; MAGNETIC RESONANCE IMAGING CONTRAST AGENTS; MOLECULAR LEVELS; MOLECULAR PROBES; NATURAL LIGANDS; NEURAL ACTIVITY; NEUROTRANSMITTER RELEASE; NON-INVASIVE IMAGING; OPTICAL ABSORBANCE; PARAMAGNETIC HEMES; PC12 CELLS; PROTEIN ENGINEERING; SIGNAL ENHANCEMENT; SIGNALING PROCESS; SPATIAL RESOLUTION;

ANIMALS; BIOCHEMICAL ENGINEERING; DISSOCIATION; GENETIC ENGINEERING; HEMOGLOBIN; LIGANDS; MAGNETIC RESONANCE; MAGNETIC RESONANCE IMAGING; PORPHYRINS; PROBES; SENSORS; SIGNAL SYSTEMS;

BRAIN;

CONTRAST MEDIUM; CYTOCHROME P450 BM3; DOPAMINE; HEME; IRON; LIGAND;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN; CONTROLLED STUDY; DEPOLARIZATION; DIRECTED MOLECULAR EVOLUTION; DISSOCIATION; ELECTRON SPIN RESONANCE; IN VIVO STUDY; LIGAND BINDING; MOLECULE; NEUROTRANSMITTER RELEASE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; PROTEIN DOMAIN; RAT; SENSITIVITY AND SPECIFICITY; SENSOR; SIGNAL TRANSDUCTION;

ANIMALS; BACTERIAL PROTEINS; BRAIN; BRAIN CHEMISTRY; CELL LINE, TUMOR; CONTRAST MEDIA; CYTOCHROME P-450 ENZYME SYSTEM; DIRECTED MOLECULAR EVOLUTION; DOPAMINE; DRUG DESIGN; MAGNETIC RESONANCE IMAGING; NADPH-FERRIHEMOPROTEIN REDUCTASE; PROTEIN ENGINEERING; PROTEIN STRUCTURE, TERTIARY; RATS;

ANIMALIA; BACTERIA (MICROORGANISMS);

EID: 77749317558     PISSN: 10870156     EISSN: 15461696     Source Type: Journal    
DOI: 10.1038/nbt.1609     Document Type: Article

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