Thiazolo[3,2-b]-1,2,4-triazole-5(6H)-one substituted with ibuprofen: Novel non-steroidal anti-inflammatory agents with favorable gastrointestinal tolerance

European Journal of Medicinal Chemistry

Volumn 57, Issue , 2012, Pages 398-406

  Uzgören Baran, Ayşe ^a   Tel, Banu Cahide ^a   Sargöl, Deniz ^a   Öztürk, Elif Inci ^a   Kazkayas, Inci ^a   Okay, Gürol ^b   Ertan, Mevlüt ^a   Tozkoparan, Birsen ^a  

^a HACETTEPE UNIVERSITY   (Turkey)

^b SIIRT UNIVERSITY   (Turkey)

Author keywords

Analgesic activity; Anti inflammatory activity; Gastric risk; Ibuprofen derivatives; Thiazolo 3,2 b 1,2,4 triazole 5(6H) one

Indexed keywords

(1 METHYLPYRROL 2 YL)METHYLIDENE DERIVATIVE; (BIPHENYL 4 YL)METHYLIDENE DERIVATIVE; 3 [1 [4 (2 METHYLPROPYL)PHENYL]ETHYL] 1,2,4 TRIAZOLE 5 THIONE; 3 PHENYL 2 PROPENYLIDENE DERIVATIVE; CELECOXIB; IBUPROFEN; IBUPROFEN DERIVATIVE; INDOMETACIN; NONSTEROID ANTIINFLAMMATORY AGENT; OXYCODONE; ROFECOXIB; THIAZOLE DERIVATIVE; THIAZOLO[3,2 B] 1,2,4 TRIAZOLE 5(6H) ONE DERIVATIVE; UNCLASSIFIED DRUG;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DRUG SAFETY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; GASTROINTESTINAL TOXICITY; HOT PLATE TEST; IN VIVO STUDY; MOUSE; NONHUMAN; PAW EDEMA; STOMACH MUCOSA INJURY; STRUCTURE ACTIVITY RELATION; TAIL FLICK TEST; ULCEROGENESIS;

ANALGESICS; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CARRAGEENAN; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG TOLERANCE; EDEMA; FEMALE; IBUPROFEN; INDOMETHACIN; MALE; MICE; PAIN MEASUREMENT; STOMACH; STOMACH ULCER; STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZOLES;

EID: 84870060933     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2012.07.009     Document Type: Article

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