Expression of costimulatory molecule B7-H4 in human malignant tumors

Onkologie

Volumn 35, Issue 11, 2012, Pages 700-705

  Zheng, Xiao ^a   Li, Xiao Dong ^a   Wu, Chang Ping ^a   Lu, Bin Feng ^b   Jiang, Jing Ting ^a  

^a THE THIRD AFFILIATED HOSPITAL OF SOOCHOW UNIVERSITY   (China)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

B7 H4; Costimulatory signal; Immune invasion; Malignant tumor; Molecular target

Indexed keywords

CELL SURFACE PROTEIN; V SET DOMAIN CONTAINING T CELL ACTIVATION INHIBITOR 1;

ANTIGEN EXPRESSION; BRAIN TUMOR; BREAST CANCER; CANCER GROWTH; CANCER INVASION; CANCER MORTALITY; CANCER PROGNOSIS; ENDOMETRIUM CARCINOMA; HUMAN; IMMUNOHISTOCHEMISTRY; IMMUNOREGULATION; KIDNEY CARCINOMA; LUNG NON SMALL CELL CANCER; LYMPH NODE METASTASIS; MALIGNANT NEOPLASTIC DISEASE; MALIGNANT TRANSFORMATION; MOLECULARLY TARGETED THERAPY; OVARY CANCER; PANCREAS ADENOCARCINOMA; PANCREAS CANCER; PROSTATE CANCER; REVIEW; STOMACH CANCER; TUMOR ASSOCIATED LEUKOCYTE; TUMOR REGRESSION;

BIOLOGICAL MARKERS; HUMANS; MODELS, BIOLOGICAL; NEOPLASM PROTEINS; NEOPLASMS; V-SET DOMAIN-CONTAINING T-CELL ACTIVATION INHIBITOR 1;

EID: 84870030780     PISSN: 0378584X     EISSN: 14230240     Source Type: Journal    
DOI: 10.1159/000343638     Document Type: Review

References (26)

1. Sharpe A: Costimulation and regulation of autoimmunity and tolerance. J Pediatr Gastroenterol Nutr 2005;40 Suppl 1:S20-21.
2. Chen L: Co-inhibitory molecules of the B7-CD28 family in the control of T-cell immunity. Nat Rev Immunol 2004;4:336-347.
3. Korman AJ, Peggs KS, Allison JP: Checkpoint blockade in cancer immunotherapy. Adv Immunol 2006;90:297-339.
4. Sharpe AH, Freeman GJ: The B7-CD28 superfamily. Nat Rev Immunol 2002;2:116-126.
5. Choi IH, Zhu G, Sica GL, Strome SE, Cheville JC, Lau JS, Zhu Y, Flies DB, Tamada K, Chen L: Genomic organization and expression analysis of B7-H4, an immune inhibitory molecule of the B7 family. J Immunol 2003;171:4650-4654.
6. Sica GL, Choi IH, Zhu G, Tamada K, Wang SD, Tamura H, Chapoval AI, Flies DB, Bajorath J, Chen L: B7-H4, a molecule of the B7 family, negatively regulates T cell immunity. Immunity 2003; 18:849-861.
7. Tringler B, Zhuo S, Pilkington G, Torkko KC, Singh M, Lucia MS, Heinz DE, Papkoff J, Shroyer KR: B7-H4 is highly expressed in ductal and lobular breast cancer. Clin Cancer Res 2005;11:1842- 1848.
8. Balkwill F: Cancer and the chemokine network. Nat Rev Cancer 2004;4:540-550.
9. Coussens LM, Werb Z: Inflammation and cancer. Nature 2002;420:860-867.
10. Zou W: Immunosuppressive networks in the tumour environment and their therapeutic relevance. Nat Rev Cancer 2005;5:263-274.
11. Kryczek I, Wei S, Zhu G, Myers L, Mottram P, Cheng P, Chen L, Coukos G, Zou W: Relationship between B7-H4, regulatory T cells, and patient outcome in human ovarian carcinoma. Cancer Res 2007;67:8900-8905.
12. Kryczek I, Wei S, Zou L, Zhu G, Mottram P, Xu H, Chen L, Zou W: Cutting edge: induction of B7-H4 on APCs through IL-10: Novel suppressive mode for regulatory T cells. J Immunol 2006;177: 40-44.
13. Kryczek I, Zou L, Rodriguez P, Zhu G, Wei S, Mottram P, Brumlik M, Cheng P, Curiel T, Myers L, Lackner A, Alvarez X, Ochoa A, Chen L, Zou W: B7-H4 expression identifies a novel suppressive macrophage population in human ovarian carcinoma. J Exp Med 2006;203:871-881.
14. Chen C, Qu QX, Shen Y, Mu CY, Zhu YB, Zhang XG, Huang JA: Induced expression of B7-H4 on the surface of lung cancer cell by the tumor- associated macrophages: A potential mechanism of immune escape. Cancer Lett 2012;317:99- 105.
15. Cheng C, Qu QX, Shen Y, Lv YT, Zhu YB, Zhang XG, Huang JA: Overexpression of B7-H4 in tumor infiltrated dendritic cells. J Immunoassay Immunochem 2011;32:353-364.
16. Jiang J, Zhu Y, Wu C, Shen Y, Wei W, Chen L, Zheng X, Sun J, Lu B, Zhang X: Tumor expression of B7-H4 predicts poor survival of patients suffering from gastric cancer. Cancer Immunol Immunother 2010;59:1707-1714.
17. Sun Y, Wang Y, Zhao J, Gu M, Giscombe R, Lefvert AK, Wang X: B7-H3 and B7-H4 expression in non-small-cell lung cancer. Lung Cancer 2006;53:143-151.
18. Salceda S, Tang T, Kmet M, Munteanu A, Ghosh M, Macina R, Liu W, Pilkington G, Papkoff J: The immunomodulatory protein B7-H4 is overexpressed in breast and ovarian cancers and promotes epithelial cell transformation. Exp Cell Res 2005;306:128-141.
19. Simon I, Zhuo S, Corral L, Diamandis EP, Sarno MJ, Wolfert RL, Kim NW: B7-H4 is a novel membrane-bound protein and a candidate serum and tissue biomarker for ovarian cancer. Cancer Res 2006;66:1570-1575.
20. Simon I, Katsaros D, Rigault de la Longrais I, Massobrio M, Scorilas A, Kim NW, Sarno MJ, Wolfert RL, Diamandis EP: B7-H4 is over-expressed in early-stage ovarian cancer and is independent of CA125 expression. Gynecol Oncol 2007;106:334-341.
21. Tringler B, Liu W, Corral L, Torkko KC, Enomoto T, Davidson S, Lucia MS, Heinz DE, Papkoff J, Shroyer KR: B7-H4 overexpression in ovarian tumors. Gynecol Oncol 2006;100:44-52.
22. Miyatake T, Tringler B, Liu W, Liu SH, Papkoff J, Enomoto T, Torkko KC, Dehn DL, Swisher A, Shroyer KR: B7-H4 (DD-O110) is overexpressed in high risk uterine endometrioid adenocarcinomas and inversely correlated with tumor T-cell infiltration. Gynecol Oncol 2007;106:119-127.
23. Krambeck AE, Thompson RH, Dong H, Lohse CM, Park ES, Kuntz SM, Leibovich BC, Blute ML, Cheville JC, Kwon ED: B7-H4 expression in renal cell carcinoma and tumor vasculature: associations with cancer progression and survival. Proc Natl Acad Sci USA 2006;103:10391-10396.
24. Yao Y, Wang X, Jin K, Zhu J, Wang Y, Xiong S, Mao Y, Zhou L: B7-H4 is preferentially expressed in non-dividing brain tumor cells and in a subset of brain tumor stem-like cells. J Neurooncol 2008; 89:121-129.
25. Awadallah NS, Shroyer KR, Langer DA, Torkko KC, Chen YK, Bentz JS, Papkoff J, Liu W, Nash SR, Shah RJ: Detection of B7-H4 and p53 in pancreatic cancer: potential role as a cytological diagnostic adjunct. Pancreas 2008;36:200-206.
26. Zang X, Thompson RH, Al-Ahmadie HA, Serio AM, Reuter VE, Eastham JA, Scardino PT, Sharma P, Allison JP: B7-H3 and B7x are highly expressed in human prostate cancer and associated with disease spread and poor outcome. Proc Natl Acad Sci USA 2007:19458-19463.