Role of human TLR4 in respiratory syncytial virus-induced NF-κB activation, viral entry and replication

Innate Immunity

Volumn 18, Issue 6, 2012, Pages 856-865

  Marr, Nico ^a   Turvey, Stuart E ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

innate immunity; RSV; TLR4

Indexed keywords

CD14 ANTIGEN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN MD 2; TOLL LIKE RECEPTOR 4;

ARTICLE; HUMAN; HUMAN CELL; NONHUMAN; PROTEIN FUNCTION; RESPIRATORY SYNCYTIAL PNEUMOVIRUS; RESPIRATORY SYNCYTIAL VIRUS INFECTION; VIRUS CELL INTERACTION; VIRUS ENTRY; VIRUS REPLICATION;

ANTIGENS, CD14; HEK293 CELLS; HUMANS; IMMUNITY, INNATE; LIPOPOLYSACCHARIDES; LYMPHOCYTE ANTIGEN 96; NF-KAPPA B; PROTEIN BINDING; RESPIRATORY SYNCYTIAL VIRUS INFECTIONS; RESPIRATORY SYNCYTIAL VIRUSES; TOLL-LIKE RECEPTOR 4; TRANSCRIPTIONAL ACTIVATION; TRANSGENES; VIRAL FUSION PROTEINS; VIRUS INTERNALIZATION; VIRUS REPLICATION;

RESPIRATORY SYNCYTIAL VIRUS; RICE STRIPE VIRUS;

EID: 84870003094     PISSN: 17534259     EISSN: 17534267     Source Type: Journal    
DOI: 10.1177/1753425912444479     Document Type: Article

References (47)

1. Howard TS, Hoffman LH, Stang PE, Simoes EA. Respiratory syncytial virus pneumonia in the hospital setting: Length of stay, charges, and mortality. J Pediatr. 2000 ; 137: 227-232
2. Berkley JA, Munywoki P, Ngama M, Kazungu S, Abwao J, Bett A, et al. Viral etiology of severe pneumonia among kenyan infants and children. JAMA. 2010 ; 303: 2051-2057
3. Simoes EA, Carbonell-Estrany X. Impact of severe disease caused by respiratory syncytial virus in children living in developed countries. Pediatr Infect Dis J. 2003 ; 22: S13 - S18
4. Nair H, Nokes DJ, Gessner BD, Dherani M, Madhi SA, Singleton RJ, et al. Global burden of acute lower respiratory infections due to respiratory syncytial virus in young children: A systematic review and meta-analysis. Lancet. 2010 ; 375: 1545-1555
5. Graham BS. Biological challenges and technological opportunities for respiratory syncytial virus vaccine development. Immunol Rev. 2011 ; 239: 149-166
6. Kim HW, Canchola JG, Brandt CD, Pyles G, Chanock RM, Jensen K, et al. Respiratory syncytial virus disease in infants despite prior administration of antigenic inactivated vaccine. Am J Epidemiol. 1969 ; 89: 422-434
7. Tian B, Zhang Y, Luxon BA, Garofalo RP, Casola A, Sinha M, et al. Identification of NF-κB-dependent gene networks in respiratory syncytial virus-infected cells. J Virol. 2002 ; 76: 6800-6814
8. Yoboua F, Martel A, Duval A, Mukawera E, Grandvaux N. Respiratory syncytial virus-mediated NF-κB p65 phosphorylation at serine 536 is dependent on RIG-I, TRAF6, and IKK beta. J Virol. 2010 ; 84: 7267-7277
9. Bao X, Indukuri H, Liu T, Liao SL, Tian B, Brasier AR, et al. Ikkε modulates RSV-induced NF-κB-dependent gene transcription. Virology. 2010 ; 408: 224-231
10. Casola A, Garofalo RP, Haeberle H, Elliott TF, Lin R, Jamaluddin M, et al. Multiple cis regulatory elements control rantes promoter activity in alveolar epithelial cells infected with respiratory syncytial virus. J Virol. 2001 ; 75: 6428-6439
11. Garofalo R, Sabry M, Jamaluddin M, Yu RK, Casola A, Ogra PL, et al. Transcriptional activation of the interleukin-8 gene by respiratory syncytial virus infection in alveolar epithelial cells: Nuclear translocation of the RelA transcription factor as a mechanism producing airway mucosal inflammation. J Virol. 1996 ; 70: 8773-8781
12. Hayden MS, Ghosh S. NF-κB in immunobiology. Cell Res. 2011 ; 21: 223-244
13. Mercurio F, Manning AM. Multiple signals converging on NF-κB. Curr Opin Cell Biol. 1999 ; 11: 226-232
14. Kurt-Jones EA, Popova L, Kwinn L, Haynes LM, Jones LP, Tripp RA, et al. Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus. Nat Immunol. 2000 ; 1: 398-401
15. Lizundia R, Sauter KS, Taylor G, Werling D. Host species-specific usage of the TLR4-LPS receptor complex. Innate Immun. 2008 ; 14: 223-231
16. Haynes LM, Moore DD, Kurt-Jones EA, Finberg RW, Anderson LJ, Tripp RA. Involvement of Toll-like receptor 4 in innate immunity to respiratory syncytial virus. J Virol. 2001 ; 75: 10730-10737
17. Haeberle HA, Takizawa R, Casola A, Brasier AR, Dieterich HJ, Van Rooijen N, et al. Respiratory syncytial virus-induced activation of NF-κB in the lung involves alveolar macrophages and Toll-like receptor 4-dependent pathways. J Infect Dis. 2002 ; 186: 1199-1206
18. Ehl S, Bischoff R, Ostler T, Vallbracht S, Schulte-Monting J, Poltorak A, et al. The role of Toll-like receptor 4 versus interleukin-12 in immunity to respiratory syncytial virus. Eur J Immunol. 2004 ; 34: 1146-1153
19. Delgado MF, Coviello S, Monsalvo AC, Melendi GA, Hernandez JZ, Batalle JP, et al. Lack of Ab affinity maturation due to poor Toll-like receptor stimulation leads to enhanced respiratory syncytial virus disease. Nat Med. 2009 ; 15: 34-41
20. Boukhvalova MS, Prince GA, Soroush L, Harrigan DC, Vogel SN, Blanco JC. The TLR4 agonist, monophosphoryl lipid A, attenuates the cytokine storm associated with respiratory syncytial virus vaccine-enhanced disease. Vaccine. 2006 ; 24: 5027-5035
21. Prince GA, Denamur F, Deschamps M, Garcon N, Prieels JP, Slaoui M, et al. Monophosphoryl lipid A adjuvant reverses a principal histologic parameter of formalin-inactivated respiratory syncytial virus vaccine-induced disease. Vaccine. 2001 ; 19: 2048-2054
22. Poltorak A, Merlin T, Nielsen PJ, Sandra O, Smirnova I, Schupp I, et al. A point mutation in the IL-12R beta 2 gene underlies the IL-12 unresponsiveness of LPS-defective c57BL/10ScCr mice. J Immunol. 2001 ; 167: 2106-2111
23. Tal G, Mandelberg A, Dalal I, Cesar K, Somekh E, Tal A, et al. Association between common Toll-like receptor 4 mutations and severe respiratory syncytial virus disease. J Infect Dis. 2004 ; 189: 2057-2063
24. Awomoyi AA, Rallabhandi P, Pollin TI, Lorenz E, Sztein MB, Boukhvalova MS, et al. Association of TLR4 polymorphisms with symptomatic respiratory syncytial virus infection in high-risk infants and young children. J Immunol. 2007 ; 179: 3171-3177
25. Paulus SC, Hirschfeld AF, Victor RE, Brunstein J, Thomas E, Turvey SE. Common human Toll-like receptor 4 polymorphisms-role in susceptibility to respiratory syncytial virus infection and functional immunological relevance. Clin Immunol. 2007 ; 123: 252-257
26. Douville RN, Lissitsyn Y, Hirschfeld AF, Becker AB, Kozyrskyj AL, Liem J, et al. TLR4 Asp299Gly and Thr399Ile polymorphisms: No impact on human immune responsiveness to LPS or respiratory syncytial virus. PLoS One. 2010 ; 5: e12087 - e12087
27. Chaiwatpongsakorn S, Epand RF, Collins PL, Epand RM, Peeples ME. Soluble respiratory syncytial virus fusion protein in the fully cleaved, pretriggered state is triggered by exposure to low-molarity buffer. J Virol. 2011 ; 85: 3968-3977
28. Marr N, Novikov A, Hajjar AM, Caroff M, Fernandez RC. Variability in the lipooligosaccharide structure and endotoxicity among Bordetella pertussis strains. J Infect Dis. 2010 ; 202: 1897-1906
29. Marr N, Hajjar AM, Shah NR, Novikov A, Yam CS, Caroff M, et al. Substitution of the Bordetella pertussis lipid A phosphate groups with glucosamine is required for robust NF-κB activation and release of proinflammatory cytokines in cells expressing human but not murine Toll-like receptor 4-MD-2-CD14. Infect Immun. 2010 ; 78: 2060-2069
30. Hajjar AM, Ernst RK, Tsai JH, Wilson CB, Miller SI. Human Toll-like receptor 4 recognizes host-specific LPS modifications. Nat Immunol. 2002 ; 3: 354-359
31. Kwilas AR, Yednak MA, Zhang L, Liesman R, Collins PL, Pickles RJ, et al. Respiratory syncytial virus engineered to express the cystic fibrosis transmembrane conductance regulator corrects the bioelectric phenotype of human cystic fibrosis airway epithelium in vitro. J Virol. 2010 ; 84: 7770-7781
32. Tayyari F, Marchant D, Moraes TJ, Duan W, Mastrangelo P, Hegele RG. Identification of nucleolin as a cellular receptor for human respiratory syncytial virus. Nat Med. 2011 ; 17: 1132-1135
33. Ueba O. Respiratory syncytial virus. I. Concentration and purification of the infectious virus. Acta Med Okayama. 1978 ; 32: 265-272
34. Park BS, Song DH, Kim HM, Choi BS, Lee H, Lee JO. The structural basis of lipopolysaccharide recognition by the TLR4-MD-2 complex. Nature. 2009 ; 458: 1191-1195
35. Golenbock DT, Hampton RY, Qureshi N, Takayama K, Raetz CR. Lipid A-like molecules that antagonize the effects of endotoxins on human monocytes. J Biol Chem. 1991 ; 266: 19490-19498
36. Jiang Z, Georgel P, Du X, Shamel L, Sovath S, Mudd S, et al. CD14 is required for MYD88-independent LPS signaling. Nat Immunol. 2005 ; 6: 565-570
37. Kwilas S, Liesman RM, Zhang L, Walsh E, Pickles RJ, Peeples ME. Respiratory syncytial virus grown in Vero cells contains a truncated attachment protein that alters its infectivity and dependence on glycosaminoglycans. J Virol. 2009 ; 83: 10710-10718
38. Hendricks DA, Baradaran K, McIntosh K, Patterson JL. Appearance of a soluble form of the G protein of respiratory syncytial virus in fluids of infected cells. J Gen Virol. 1987 ; 68: 1705-1714
39. Park JS, Gamboni-Robertson F, He Q, Svetkauskaite D, Kim JY, Strassheim D, et al. High mobility group box 1 protein interacts with multiple Toll-like receptors. Am J Physiol Cell Physiol. 2006 ; 290: C917 - C924
40. Vogl T, Tenbrock K, Ludwig S, Leukert N, Ehrhardt C, van Zoelen MA, et al. MRP8 and MRP14 are endogenous activators of Toll-like receptor 4, promoting lethal, endotoxin-induced shock. Nat Med. 2007 ; 13: 1042-1049
41. Shirey KA, Pletneva LM, Puche AC, Keegan AD, Prince GA, Blanco JC, et al. Control of RSV-induced lung injury by alternatively activated macrophages is IL-4R alpha-, TLR4-, and IFN-beta-dependent. Mucosal Immunol. 2010 ; 3: 291-300
42. Benjamin JT, Carver BJ, Plosa EJ, Yamamoto Y, Miller JD, Liu JH, et al. NF-κB activation limits airway branching through inhibition of SP1-mediated fibroblast growth factor-10 expression. J Immunol. 2010 ; 185: 4896-4903
43. Benjamin JT, Smith RJ, Halloran BA, Day TJ, Kelly DR, Prince LS. FGF-10 is decreased in bronchopulmonary dysplasia and suppressed by Toll-like receptor activation. Am J Physiol Lung Cell Mol Physiol. 2007 ; 292: L550 - L558
44. Simpson A, Martinez FD. The role of lipopolysaccharide in the development of atopy in humans. Clin Exp Allergy. 2010 ; 40: 209-223
45. Lindemans CA, Coffer PJ, Schellens IM, de Graaff PM, Kimpen JL, Koenderman L. Respiratory syncytial virus inhibits granulocyte apoptosis through a phosphatidylinositol 3-kinase and NF-κB-dependent mechanism. J Immunol. 2006 ; 176: 5529-5537
46. Marchant D, Singhera GK, Utokaparch S, Hackett TL, Boyd JH, Luo Z, et al. Toll-like receptor 4-mediated activation of p38 mitogen-activated protein kinase is a determinant of respiratory virus entry and tropism. J Virol. 2010 ; 84: 11359-11373
47. Shingai M, Azuma M, Ebihara T, Sasai M, Funami K, Ayata M, et al. Soluble G protein of respiratory syncytial virus inhibits Toll-like receptor 3/4-mediated IFN-beta induction. Int Immunol. 2008 ; 20: 1169-1180