메뉴 건너뛰기




Volumn 7, Issue 11, 2012, Pages

Proteinuria Triggers Renal Lymphangiogenesis Prior to the Development of Interstitial Fibrosis

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; CREATININE; MESSENGER RNA; OSTEOPONTIN; PODOPLANIN; VASCULOTROPIN C; VASCULOTROPIN RECEPTOR 3;

EID: 84869992864     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0050209     Document Type: Article
Times cited : (37)

References (52)
  • 1
    • 0032512094 scopus 로고    scopus 로고
    • Pathophysiology of progressive nephropathies
    • Remuzzi G, Bertani T, (1998) Pathophysiology of progressive nephropathies. N Engl J Med 339(20): 1448-1456.
    • (1998) N Engl J Med , vol.339 , Issue.20 , pp. 1448-1456
    • Remuzzi, G.1    Bertani, T.2
  • 2
    • 0034118392 scopus 로고    scopus 로고
    • Renoprotective benefits of RAS inhibition: From ACEI to angiotensin II antagonists
    • Taal MW, Brenner BM, (2000) Renoprotective benefits of RAS inhibition: From ACEI to angiotensin II antagonists. Kidney Int 57(5): 1803-1817.
    • (2000) Kidney Int , vol.57 , Issue.5 , pp. 1803-1817
    • Taal, M.W.1    Brenner, B.M.2
  • 3
    • 40149083478 scopus 로고    scopus 로고
    • Slowing nephropathy progression: Focus on proteinuria reduction
    • Bakris GL, (2008) Slowing nephropathy progression: Focus on proteinuria reduction. Clin J Am Soc Nephrol 3 (Suppl 1): S3-10.
    • (2008) Clin J Am Soc Nephrol , vol.3 , Issue.SUPPL. 1
    • Bakris, G.L.1
  • 4
    • 1042280361 scopus 로고    scopus 로고
    • Proteinuria and interstitial injury
    • Eddy AA, (2004) Proteinuria and interstitial injury. Nephrol Dial Transplant 19(2): 277-281.
    • (2004) Nephrol Dial Transplant , vol.19 , Issue.2 , pp. 277-281
    • Eddy, A.A.1
  • 5
    • 0028848466 scopus 로고
    • Proximal tubular cell synthesis and secretion of endothelin-1 on challenge with albumin and other proteins
    • Zoja C, Morigi M, Figliuzzi M, Bruzzi I, Oldroyd S, et al. (1995) Proximal tubular cell synthesis and secretion of endothelin-1 on challenge with albumin and other proteins. Am J Kidney Dis 26(6): 934-941.
    • (1995) Am J Kidney Dis , vol.26 , Issue.6 , pp. 934-941
    • Zoja, C.1    Morigi, M.2    Figliuzzi, M.3    Bruzzi, I.4    Oldroyd, S.5
  • 6
    • 23944506156 scopus 로고    scopus 로고
    • Albumin activates ERK via EGF receptor in human renal epithelial cells
    • Reich H, Tritchler D, Herzenberg AM, Kassiri Z, Zhou X, et al. (2005) Albumin activates ERK via EGF receptor in human renal epithelial cells. J Am Soc Nephrol 16(5): 1266-1278.
    • (2005) J Am Soc Nephrol , vol.16 , Issue.5 , pp. 1266-1278
    • Reich, H.1    Tritchler, D.2    Herzenberg, A.M.3    Kassiri, Z.4    Zhou, X.5
  • 7
    • 0036098878 scopus 로고    scopus 로고
    • Proximal tubular cells promote fibrogenesis by TGF-beta1-mediated induction of peritubular myofibroblasts
    • Abbate M, Zoja C, Rottoli D, Corna D, Tomasoni S, et al. (2002) Proximal tubular cells promote fibrogenesis by TGF-beta1-mediated induction of peritubular myofibroblasts. Kidney Int 61(6): 2066-2077.
    • (2002) Kidney Int , vol.61 , Issue.6 , pp. 2066-2077
    • Abbate, M.1    Zoja, C.2    Rottoli, D.3    Corna, D.4    Tomasoni, S.5
  • 8
    • 0037324549 scopus 로고    scopus 로고
    • Albumin stimulates interleukin-8 expression in proximal tubular epithelial cells in vitro and in vivo
    • Tang S, Leung JC, Abe K, Chan KW, Chan LY, et al. (2003) Albumin stimulates interleukin-8 expression in proximal tubular epithelial cells in vitro and in vivo. J Clin Invest 111(4): 515-527.
    • (2003) J Clin Invest , vol.111 , Issue.4 , pp. 515-527
    • Tang, S.1    Leung, J.C.2    Abe, K.3    Chan, K.W.4    Chan, L.Y.5
  • 9
    • 0025883784 scopus 로고
    • Sublethal X-irradiation during acute puromycin nephrosis prevents late renal injury: Role of macrophages
    • Diamond JR, Pesek-Diamond I, (1991) Sublethal X-irradiation during acute puromycin nephrosis prevents late renal injury: Role of macrophages. Am J Physiol 260(6 Pt 2): F779-86.
    • (1991) Am J Physiol , vol.260 , Issue.6 Pt 2
    • Diamond, J.R.1    Pesek-Diamond, I.2
  • 10
    • 26944492287 scopus 로고    scopus 로고
    • Macrophages and progressive tubulointerstitial disease
    • Sean Eardley K, Cockwell P, (2005) Macrophages and progressive tubulointerstitial disease. Kidney Int 68(2): 437-455.
    • (2005) Kidney Int , vol.68 , Issue.2 , pp. 437-455
    • Sean Eardley, K.1    Cockwell, P.2
  • 11
    • 0025285191 scopus 로고
    • Long-term prognosis of focal sclerosing glomerulonephritis. an analysis of 250 cases with particular regard to tubulointerstitial changes
    • Wehrmann M, Bohle A, Held H, Schumm G, Kendziorra H, et al. (1990) Long-term prognosis of focal sclerosing glomerulonephritis. an analysis of 250 cases with particular regard to tubulointerstitial changes. Clin Nephrol 33(3): 115-122.
    • (1990) Clin Nephrol , vol.33 , Issue.3 , pp. 115-122
    • Wehrmann, M.1    Bohle, A.2    Held, H.3    Schumm, G.4    Kendziorra, H.5
  • 12
    • 12144264180 scopus 로고    scopus 로고
    • Proteinuria and growth factors in the development of tubulointerstitial injury and scarring in kidney disease
    • Hirschberg R, Wang S, (2005) Proteinuria and growth factors in the development of tubulointerstitial injury and scarring in kidney disease. Curr Opin Nephrol Hypertens 14(1): 43-52.
    • (2005) Curr Opin Nephrol Hypertens , vol.14 , Issue.1 , pp. 43-52
    • Hirschberg, R.1    Wang, S.2
  • 13
    • 0141738521 scopus 로고    scopus 로고
    • Inter-individual differences in anti-proteinuric response to ACEi in established adriamycin nephrotic rats are predicted by pretreatment renal damage
    • Kramer AB, Laverman GD, van Goor H, Navis G, (2003) Inter-individual differences in anti-proteinuric response to ACEi in established adriamycin nephrotic rats are predicted by pretreatment renal damage. J Pathol 201(1): 160-167.
    • (2003) J Pathol , vol.201 , Issue.1 , pp. 160-167
    • Kramer, A.B.1    Laverman, G.D.2    van Goor, H.3    Navis, G.4
  • 14
    • 0028218865 scopus 로고
    • Renal cortical interstitium and fluid absorption by peritubular capillaries
    • Aukland K, Bogusky RT, Renkin EM, (1994) Renal cortical interstitium and fluid absorption by peritubular capillaries. Am J Physiol 266(2 Pt 2): F175-84.
    • (1994) Am J Physiol , vol.266 , Issue.2 Pt 2
    • Aukland, K.1    Bogusky, R.T.2    Renkin, E.M.3
  • 15
    • 38949132160 scopus 로고    scopus 로고
    • Disturbance of lymph circulation develops renal fibrosis in rats with or without contralateral nephrectomy
    • Zhang T, Guan G, Liu G, Sun J, Chen B, et al. (2008) Disturbance of lymph circulation develops renal fibrosis in rats with or without contralateral nephrectomy. Nephrology (Carlton) 13(2): 128-138.
    • (2008) Nephrology (Carlton) , vol.13 , Issue.2 , pp. 128-138
    • Zhang, T.1    Guan, G.2    Liu, G.3    Sun, J.4    Chen, B.5
  • 16
    • 77957682470 scopus 로고    scopus 로고
    • Current views on the function of the lymphatic vasculature in health and disease
    • Wang Y, Oliver G, (2010) Current views on the function of the lymphatic vasculature in health and disease. Genes Dev 24(19): 2115-2126.
    • (2010) Genes Dev , vol.24 , Issue.19 , pp. 2115-2126
    • Wang, Y.1    Oliver, G.2
  • 17
    • 76749083490 scopus 로고    scopus 로고
    • Lymphangiogenesis: Molecular mechanisms and future promise
    • Tammela T, Alitalo K, (2010) Lymphangiogenesis: Molecular mechanisms and future promise. Cell 140(4): 460-476.
    • (2010) Cell , vol.140 , Issue.4 , pp. 460-476
    • Tammela, T.1    Alitalo, K.2
  • 18
    • 84862491030 scopus 로고    scopus 로고
    • Aberrant mural cell recruitment to lymphatic vessels and impaired lymphatic drainage in a murine model of pulmonary fibrosis
    • Meinecke AK, Nagy N, Lago GD, Kirmse S, Klose R, et al. (2012) Aberrant mural cell recruitment to lymphatic vessels and impaired lymphatic drainage in a murine model of pulmonary fibrosis. Blood 119(24): 5931-5942.
    • (2012) Blood , vol.119 , Issue.24 , pp. 5931-5942
    • Meinecke, A.K.1    Nagy, N.2    Lago, G.D.3    Kirmse, S.4    Klose, R.5
  • 19
    • 10744229023 scopus 로고    scopus 로고
    • Lymphatic neoangiogenesis in human kidney transplants is associated with immunologically active lymphocytic infiltrates
    • Kerjaschki D, Regele HM, Moosberger I, Nagy-Bojarski K, Watschinger B, et al. (2004) Lymphatic neoangiogenesis in human kidney transplants is associated with immunologically active lymphocytic infiltrates. J Am Soc Nephrol 15(3): 603-612.
    • (2004) J Am Soc Nephrol , vol.15 , Issue.3 , pp. 603-612
    • Kerjaschki, D.1    Regele, H.M.2    Moosberger, I.3    Nagy-Bojarski, K.4    Watschinger, B.5
  • 20
    • 32244436571 scopus 로고    scopus 로고
    • Lymphatic endothelial progenitor cells contribute to de novo lymphangiogenesis in human renal transplants
    • Kerjaschki D, Huttary N, Raab I, Regele H, Bojarski-Nagy K, et al. (2006) Lymphatic endothelial progenitor cells contribute to de novo lymphangiogenesis in human renal transplants. Nat Med 12(2): 230-234.
    • (2006) Nat Med , vol.12 , Issue.2 , pp. 230-234
    • Kerjaschki, D.1    Huttary, N.2    Raab, I.3    Regele, H.4    Bojarski-Nagy, K.5
  • 21
    • 63949084807 scopus 로고    scopus 로고
    • Lymphatic vessels develop during tubulointerstitial fibrosis
    • Sakamoto I, Ito Y, Mizuno M, Suzuki Y, Sawai A, et al. (2009) Lymphatic vessels develop during tubulointerstitial fibrosis. Kidney Int 75(8): 828-838.
    • (2009) Kidney Int , vol.75 , Issue.8 , pp. 828-838
    • Sakamoto, I.1    Ito, Y.2    Mizuno, M.3    Suzuki, Y.4    Sawai, A.5
  • 22
    • 84859741661 scopus 로고    scopus 로고
    • Transforming growth factor-beta induces vascular endothelial growth factor-C expression leading to lymphangiogenesis in rat unilateral ureteral obstruction
    • Suzuki Y, Ito Y, Mizuno M, Kinashi H, Sawai A, et al. (2012) Transforming growth factor-beta induces vascular endothelial growth factor-C expression leading to lymphangiogenesis in rat unilateral ureteral obstruction. Kidney Int 81(9): 865-879.
    • (2012) Kidney Int , vol.81 , Issue.9 , pp. 865-879
    • Suzuki, Y.1    Ito, Y.2    Mizuno, M.3    Kinashi, H.4    Sawai, A.5
  • 23
    • 29744445742 scopus 로고    scopus 로고
    • Modulation of osteopontin in proteinuria-induced renal interstitial fibrosis
    • Kramer AB, Ricardo SD, Kelly DJ, Waanders F, van Goor H, et al. (2005) Modulation of osteopontin in proteinuria-induced renal interstitial fibrosis. J Pathol 207(4): 483-492.
    • (2005) J Pathol , vol.207 , Issue.4 , pp. 483-492
    • Kramer, A.B.1    Ricardo, S.D.2    Kelly, D.J.3    Waanders, F.4    van Goor, H.5
  • 24
    • 0022441229 scopus 로고
    • Tubulo-interstitial lesions mediate renal damage in adriamycin glomerulopathy
    • Bertani T, Cutillo F, Zoja C, Broggini M, Remuzzi G, (1986) Tubulo-interstitial lesions mediate renal damage in adriamycin glomerulopathy. Kidney Int 30(4): 488-496.
    • (1986) Kidney Int , vol.30 , Issue.4 , pp. 488-496
    • Bertani, T.1    Cutillo, F.2    Zoja, C.3    Broggini, M.4    Remuzzi, G.5
  • 25
    • 0021179653 scopus 로고
    • Mesangial immune injury, hypertension, and progressive glomerular damage in dahl rats
    • Raij L, Azar S, Keane W, (1984) Mesangial immune injury, hypertension, and progressive glomerular damage in dahl rats. 26(2): 137-143.
    • (1984) , vol.26 , Issue.2 , pp. 137-143
    • Raij, L.1    Azar, S.2    Keane, W.3
  • 26
    • 79959916279 scopus 로고    scopus 로고
    • Visualisation and stereological assessment of blood and lymphatic vessels
    • Lokmic Z, Mitchell GM, (2011) Visualisation and stereological assessment of blood and lymphatic vessels. Histol Histopathol 26(6): 781-796.
    • (2011) Histol Histopathol , vol.26 , Issue.6 , pp. 781-796
    • Lokmic, Z.1    Mitchell, G.M.2
  • 27
    • 44449138380 scopus 로고    scopus 로고
    • Markers for microscopic imaging of lymphangiogenesis and angiogenesis
    • Baluk P, McDonald DM, (2008) Markers for microscopic imaging of lymphangiogenesis and angiogenesis. Ann N Y Acad Sci 1131: 1-12.
    • (2008) Ann N Y Acad Sci , vol.1131 , pp. 1-12
    • Baluk, P.1    McDonald, D.M.2
  • 28
    • 33750736645 scopus 로고    scopus 로고
    • How does proteinuria cause progressive renal damage?
    • Abbate M, Zoja C, Remuzzi G, (2006) How does proteinuria cause progressive renal damage? J Am Soc Nephrol 17(11): 2974-2984.
    • (2006) J Am Soc Nephrol , vol.17 , Issue.11 , pp. 2974-2984
    • Abbate, M.1    Zoja, C.2    Remuzzi, G.3
  • 29
    • 0030695443 scopus 로고    scopus 로고
    • Induction of monocyte chemoattractant protein-1 in proximal tubule cells by urinary protein
    • Wang Y, Chen J, Chen L, Tay YC, Rangan GK, et al. (1997) Induction of monocyte chemoattractant protein-1 in proximal tubule cells by urinary protein. J Am Soc Nephrol 8(10): 1537-1545.
    • (1997) J Am Soc Nephrol , vol.8 , Issue.10 , pp. 1537-1545
    • Wang, Y.1    Chen, J.2    Chen, L.3    Tay, Y.C.4    Rangan, G.K.5
  • 30
    • 0031749820 scopus 로고    scopus 로고
    • Protein overload stimulates RANTES production by proximal tubular cells depending on NF-kappa B activation
    • Zoja C, Donadelli R, Colleoni S, Figliuzzi M, Bonazzola S, et al. (1998) Protein overload stimulates RANTES production by proximal tubular cells depending on NF-kappa B activation. Kidney Int 53(6): 1608-1615.
    • (1998) Kidney Int , vol.53 , Issue.6 , pp. 1608-1615
    • Zoja, C.1    Donadelli, R.2    Colleoni, S.3    Figliuzzi, M.4    Bonazzola, S.5
  • 31
    • 84866495053 scopus 로고    scopus 로고
    • Analysis of a novel highly metastatic melanoma cell line identifies osteopontin as a new lymphangiogenic factor
    • in press
    • Liersch R, Shin J, Bayer M, Schwoeppe C, Schliemann C, et al. (2012) Analysis of a novel highly metastatic melanoma cell line identifies osteopontin as a new lymphangiogenic factor. International Journal of Oncology: in press.
    • (2012) International Journal of Oncology
    • Liersch, R.1    Shin, J.2    Bayer, M.3    Schwoeppe, C.4    Schliemann, C.5
  • 32
    • 55849103960 scopus 로고    scopus 로고
    • Macrophage diversity in renal injury and repair
    • Ricardo SD, van Goor H, Eddy AA, (2008) Macrophage diversity in renal injury and repair. J Clin Invest 118(11): 3522-3530.
    • (2008) J Clin Invest , vol.118 , Issue.11 , pp. 3522-3530
    • Ricardo, S.D.1    van Goor, H.2    Eddy, A.A.3
  • 33
    • 20144369085 scopus 로고    scopus 로고
    • Pathogenesis of persistent lymphatic vessel hyperplasia in chronic airway inflammation
    • Baluk P, Tammela T, Ator E, Lyubynska N, Achen MG, et al. (2005) Pathogenesis of persistent lymphatic vessel hyperplasia in chronic airway inflammation. J Clin Invest 115(2): 247-257.
    • (2005) J Clin Invest , vol.115 , Issue.2 , pp. 247-257
    • Baluk, P.1    Tammela, T.2    Ator, E.3    Lyubynska, N.4    Achen, M.G.5
  • 34
    • 2642641324 scopus 로고    scopus 로고
    • Proinflammatory cytokines regulate expression of the lymphatic endothelial mitogen vascular endothelial growth factor-C
    • Ristimaki A, Narko K, Enholm B, Joukov V, Alitalo K, (1998) Proinflammatory cytokines regulate expression of the lymphatic endothelial mitogen vascular endothelial growth factor-C. J Biol Chem 273(14): 8413-8418.
    • (1998) J Biol Chem , vol.273 , Issue.14 , pp. 8413-8418
    • Ristimaki, A.1    Narko, K.2    Enholm, B.3    Joukov, V.4    Alitalo, K.5
  • 35
    • 24644501637 scopus 로고    scopus 로고
    • The crucial role of macrophages in lymphangiogenesis
    • Kerjaschki D, (2005) The crucial role of macrophages in lymphangiogenesis. J Clin Invest 115(9): 2316-2319.
    • (2005) J Clin Invest , vol.115 , Issue.9 , pp. 2316-2319
    • Kerjaschki, D.1
  • 36
    • 67049167170 scopus 로고    scopus 로고
    • Critical role of CD11b+ macrophages and VEGF in inflammatory lymphangiogenesis, antigen clearance, and inflammation resolution
    • Kataru RP, Jung K, Jang C, Yang H, Schwendener RA, et al. (2009) Critical role of CD11b+ macrophages and VEGF in inflammatory lymphangiogenesis, antigen clearance, and inflammation resolution. Blood 113(22): 5650-5659.
    • (2009) Blood , vol.113 , Issue.22 , pp. 5650-5659
    • Kataru, R.P.1    Jung, K.2    Jang, C.3    Yang, H.4    Schwendener, R.A.5
  • 37
    • 0041342011 scopus 로고    scopus 로고
    • Lymphatic microvessels in the rat remnant kidney model of renal fibrosis: Aminopeptidase p and podoplanin are discriminatory markers for endothelial cells of blood and lymphatic vessels
    • Matsui K, Nagy-Bojarsky K, Laakkonen P, Krieger S, Mechtler K, et al. (2003) Lymphatic microvessels in the rat remnant kidney model of renal fibrosis: Aminopeptidase p and podoplanin are discriminatory markers for endothelial cells of blood and lymphatic vessels. J Am Soc Nephrol 14(8): 1981-1989.
    • (2003) J Am Soc Nephrol , vol.14 , Issue.8 , pp. 1981-1989
    • Matsui, K.1    Nagy-Bojarsky, K.2    Laakkonen, P.3    Krieger, S.4    Mechtler, K.5
  • 39
    • 47149083462 scopus 로고    scopus 로고
    • Inhibition of endogenous TGF-beta signaling enhances lymphangiogenesis
    • Oka M, Iwata C, Suzuki HI, Kiyono K, Morishita Y, et al. (2008) Inhibition of endogenous TGF-beta signaling enhances lymphangiogenesis. Blood 111(9): 4571-4579.
    • (2008) Blood , vol.111 , Issue.9 , pp. 4571-4579
    • Oka, M.1    Iwata, C.2    Suzuki, H.I.3    Kiyono, K.4    Morishita, Y.5
  • 41
    • 0034851108 scopus 로고    scopus 로고
    • Regulation of endothelin-1 and transforming growth factor-beta1 production in cultured proximal tubular cells by albumin and heparan sulphate glycosaminoglycans
    • Yard BA, Chorianopoulos E, Herr D, van der Woude FJ, (2001) Regulation of endothelin-1 and transforming growth factor-beta1 production in cultured proximal tubular cells by albumin and heparan sulphate glycosaminoglycans. Nephrol Dial Transplant 16(9): 1769-1775.
    • (2001) Nephrol Dial Transplant , vol.16 , Issue.9 , pp. 1769-1775
    • Yard, B.A.1    Chorianopoulos, E.2    Herr, D.3    van der Woude, F.J.4
  • 42
    • 79960222244 scopus 로고    scopus 로고
    • Role of growth factors in the development of lymphangiogenesis driven by inflammatory bowel disease: A review
    • Linares PM, Gisbert JP, (2011) Role of growth factors in the development of lymphangiogenesis driven by inflammatory bowel disease: A review. Inflamm Bowel Dis 17(8): 1814-1821.
    • (2011) Inflamm Bowel Dis , vol.17 , Issue.8 , pp. 1814-1821
    • Linares, P.M.1    Gisbert, J.P.2
  • 43
    • 0035137324 scopus 로고    scopus 로고
    • Transcription factor-kappa B (NF-kappa B) and renal disease
    • Guijarro C, Egido J, (2001) Transcription factor-kappa B (NF-kappa B) and renal disease. Kidney Int 59(2): 415-424.
    • (2001) Kidney Int , vol.59 , Issue.2 , pp. 415-424
    • Guijarro, C.1    Egido, J.2
  • 44
    • 75649083174 scopus 로고    scopus 로고
    • Inflammation induces lymphangiogenesis through up-regulation of VEGFR-3 mediated by NF-kappaB and Prox1
    • Flister MJ, Wilber A, Hall KL, Iwata C, Miyazono K, et al. (2010) Inflammation induces lymphangiogenesis through up-regulation of VEGFR-3 mediated by NF-kappaB and Prox1. Blood 115(2): 418-429.
    • (2010) Blood , vol.115 , Issue.2 , pp. 418-429
    • Flister, M.J.1    Wilber, A.2    Hall, K.L.3    Iwata, C.4    Miyazono, K.5
  • 45
    • 0036378195 scopus 로고    scopus 로고
    • Interstitial inflammation, sodium retention, and the pathogenesis of nephrotic edema: A unifying hypothesis
    • Rodriguez-Iturbe B, Herrera-Acosta J, Johnson RJ, (2002) Interstitial inflammation, sodium retention, and the pathogenesis of nephrotic edema: A unifying hypothesis. Kidney Int 62(4): 1379-1384.
    • (2002) Kidney Int , vol.62 , Issue.4 , pp. 1379-1384
    • Rodriguez-Iturbe, B.1    Herrera-Acosta, J.2    Johnson, R.J.3
  • 46
    • 66349123367 scopus 로고    scopus 로고
    • Functional, histological and biochemical consequences of renal lymph disorder in mononephrectomized rats
    • Zhang T, Liu G, Sun M, Guan G, Chen B, et al. (2009) Functional, histological and biochemical consequences of renal lymph disorder in mononephrectomized rats. J Nephrol 22(1): 109-116.
    • (2009) J Nephrol , vol.22 , Issue.1 , pp. 109-116
    • Zhang, T.1    Liu, G.2    Sun, M.3    Guan, G.4    Chen, B.5
  • 47
    • 33846161994 scopus 로고    scopus 로고
    • An experimental model for the study of lymphedema and its response to therapeutic lymphangiogenesis
    • Cheung L, Han J, Beilhack A, Joshi S, Wilburn P, et al. (2006) An experimental model for the study of lymphedema and its response to therapeutic lymphangiogenesis. BioDrugs 20(6): 363-370.
    • (2006) BioDrugs , vol.20 , Issue.6 , pp. 363-370
    • Cheung, L.1    Han, J.2    Beilhack, A.3    Joshi, S.4    Wilburn, P.5
  • 48
    • 79959657080 scopus 로고    scopus 로고
    • Targeting lymphangiogenesis after islet transplantation prolongs islet allograft survival
    • Yin N, Zhang N, Xu J, Shi Q, Ding Y, et al. (2011) Targeting lymphangiogenesis after islet transplantation prolongs islet allograft survival. Transplantation 92(1): 25-30.
    • (2011) Transplantation , vol.92 , Issue.1 , pp. 25-30
    • Yin, N.1    Zhang, N.2    Xu, J.3    Shi, Q.4    Ding, Y.5
  • 49
    • 44649193281 scopus 로고    scopus 로고
    • Inflammatory corneal (lymph)angiogenesis is blocked by VEGFR-tyrosine kinase inhibitor ZK 261991, resulting in improved graft survival after corneal transplantation
    • Hos D, Bock F, Dietrich T, Onderka J, Kruse FE, et al. (2008) Inflammatory corneal (lymph)angiogenesis is blocked by VEGFR-tyrosine kinase inhibitor ZK 261991, resulting in improved graft survival after corneal transplantation. Invest Ophthalmol Vis Sci 49(5): 1836-1842.
    • (2008) Invest Ophthalmol Vis Sci , vol.49 , Issue.5 , pp. 1836-1842
    • Hos, D.1    Bock, F.2    Dietrich, T.3    Onderka, J.4    Kruse, F.E.5
  • 50
    • 77950224116 scopus 로고    scopus 로고
    • Targeting lymphatic vessel activation and CCL21 production by vascular endothelial growth factor receptor-3 inhibition has novel immunomodulatory and antiarteriosclerotic effects in cardiac allografts
    • Nykanen AI, Sandelin H, Krebs R, Keranen MA, Tuuminen R, et al. (2010) Targeting lymphatic vessel activation and CCL21 production by vascular endothelial growth factor receptor-3 inhibition has novel immunomodulatory and antiarteriosclerotic effects in cardiac allografts. Circulation 121(12): 1413-1422.
    • (2010) Circulation , vol.121 , Issue.12 , pp. 1413-1422
    • Nykanen, A.I.1    Sandelin, H.2    Krebs, R.3    Keranen, M.A.4    Tuuminen, R.5
  • 51
    • 77957742772 scopus 로고    scopus 로고
    • Stimulation of lymphangiogenesis via VEGFR-3 inhibits chronic skin inflammation
    • Huggenberger R, Ullmann S, Proulx ST, Pytowski B, Alitalo K, et al. (2010) Stimulation of lymphangiogenesis via VEGFR-3 inhibits chronic skin inflammation. J Exp Med 207(10): 2255-2269.
    • (2010) J Exp Med , vol.207 , Issue.10 , pp. 2255-2269
    • Huggenberger, R.1    Ullmann, S.2    Proulx, S.T.3    Pytowski, B.4    Alitalo, K.5
  • 52
    • 79955957828 scopus 로고    scopus 로고
    • An important role of lymphatic vessel activation in limiting acute inflammation
    • Huggenberger R, Siddiqui SS, Brander D, Ullmann S, Zimmermann K, et al. (2011) An important role of lymphatic vessel activation in limiting acute inflammation. Blood 117(17): 4667-4678.
    • (2011) Blood , vol.117 , Issue.17 , pp. 4667-4678
    • Huggenberger, R.1    Siddiqui, S.S.2    Brander, D.3    Ullmann, S.4    Zimmermann, K.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.