Targeting Lymphatic Vessel Activation and CCL21 Production by Vascular Endothelial Growth Factor Receptor-3 Inhibition Has Novel Immunomodulatory and Antiarteriosclerotic Effects in Cardiac Allografts

Circulation

Volumn 121, Issue 12, 2010, Pages 1413-1422

  Nykänen, Antti I ^a   Sandelin, Henrik ^a   Krebs, Rainer ^a   Keränen, Mikko A I ^a   Tuuminen, Raimo ^a   Kärpänen, Terhi ^a   Wu, Yan ^d   Pytowski, Bronislaw ^d   Koskinen, Petri K ^a   Ylä Herttuala, Seppo ^c   Alitalo, Kari ^b   Lemström, Karl B ^a  

^a HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^b UNIVERSITY OF HELSINKI   (Finland)

^c UNIVERSITY OF EASTERN FINLAND   (Finland)

^d ELI LILLY AND COMPANY   (United States)

Author keywords

Angiogenesis; Arteriosclerosis; Endothelium; Immune System; Transplantation

Indexed keywords

ADENOVIRUS VECTOR; GREEN FLUORESCENT PROTEIN; HYALURONIC ACID; IMMUNOGLOBULIN; MONOCLONAL ANTIBODY; SECONDARY LYMPHOID TISSUE CHEMOKINE; TRANSCRIPTION FACTOR FOXP3; UNCLASSIFIED DRUG; VASCULOTROPIN C; VASCULOTROPIN RECEPTOR 3; VASCULOTROPIN RECEPTOR 3 IMMUNOGLOBULIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN PRESENTING CELL; ARTERIOSCLEROSIS; ARTICLE; BONE MARROW CELL; CARDIAC GRAFT REJECTION; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; ECTOPIC TISSUE; EFFECTOR CELL; GRAFT RECIPIENT; GRAFT SURVIVAL; IMMUNOMODULATION; INFLAMMATORY CELL; LYMPH VESSEL; LYMPHANGIOGENESIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; SPLEEN;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGEN-PRESENTING CELLS; ARTERIOSCLEROSIS; CELL MOVEMENT; CHEMOKINE CCL21; GRAFT REJECTION; HEART TRANSPLANTATION; IMMUNOMODULATION; LYMPHATIC VESSELS; MICE; MICE, KNOCKOUT; RATS; SIGNAL TRANSDUCTION; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-3;

EID: 77950224116     PISSN: 00097322     EISSN: 15244539     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.109.910703     Document Type: Article

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