Effects of benzene and its metabolites on global DNA methylation in human normal hepatic l02 cells

Environmental Toxicology

Volumn 29, Issue 1, 2014, Pages 108-116

  Hu, Junjie ^a,b   Ma, Huimin ^a   Zhang, Wenbing ^a   Yu, Zhiqing ^a   Sheng, Guoying ^a   Fu, Jiamo ^a  

^a GUANGZHOU INSTITUTE OF GEOCHEMISTRY   (China)

^b UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

Author keywords

Benzene; Carcinogenesis; Epigenetic; Global DNA methylation; HaeIII DNA methyltransferase; Hypomethylation; Metabolites

Indexed keywords

CARCINOGENESIS; DNA METHYLATION; DNA METHYLTRANSFERASES; EPIGENETIC; HYPOMETHYLATION;

ALKYLATION; BIOMOLECULES; CARCINOGENS; DNA; METABOLITES; METHYLATION; PATHOLOGY; PHENOLS;

BENZENE;

1,2,4 BENZENETRIOL; 1,4 BENZOQUINONE; BENZENE; DNA METHYLTRANSFERASE; HYDROQUINONE; PHENOL;

BENZENE; CARCINOGEN; DNA; ENZYME ACTIVITY; GENETIC ANALYSIS; HEALTH IMPACT; HEALTH MONITORING; METABOLITE; METHYLATION; PUBLIC HEALTH;

ARTICLE; CELL CULTURE; CONTROLLED STUDY; CYTOTOXICITY; DNA METHYLATION; ELECTROSPRAY MASS SPECTROMETRY; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME MECHANISM; EPIGENETICS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; HYDROLYSIS; IN VITRO STUDY; LIVER CELL; PRIORITY JOURNAL;

BENZENE; CARCINOGENESIS; EPIGENETIC; GLOBAL DNA METHYLATION; HAEIII DNA METHYLTRANSFERASE; HYPOMETHYLATION; METABOLITES;

BENZENE; BENZENE DERIVATIVES; CARCINOGENESIS; CARCINOGENS; CELL LINE; DEOXYRIBONUCLEASES, TYPE II SITE-SPECIFIC; DNA METHYLATION; EPIGENESIS, GENETIC; HEPATOCYTES; HUMANS;

EID: 84890555600     PISSN: 15204081     EISSN: 15227278     Source Type: Journal    
DOI: 10.1002/tox.20777     Document Type: Article

References (29)

1. Atkinson TJ. 2009. A review of the role of benzene metabolites and mechanisms in malignant transformation: Summative evidence for a lack of research in nonmyelogenous cancer types. Int J Hyg Environ Health 2121:1-10.
2. Attwood JT, Yung RL, Richardson BC. 2002. DNA methylation and the regulation of gene transcription. Cell Mol Life Sci 592:241-257.
3. Bollati V, Baccarelli A, Hou LF, Bonzini M, Fustinoni S, Cavallo D, Bynu HM, Jiang JY, Marinelli B, Pesatori AC, Bertazzi PA, Yang AS. 2007. Changes in DNA methylation patterns in subjects exposed to low-dose benzene. Cancer Res 673:876-880.
4. Buthbumrung N, Mahidol C, Navasumrit P, Promvijit J, Hunsonti P, Autrup H, Ruchirawat M. 2008. Oxidative DNA damage and influence of genetic polymorphisms among urban and rural schoolchildren exposed to benzene. Chem Biol Interact 172:185-194.
5. Chen HY, Zhang WB, Song RF, Ma HM, Dong YL, Sheng GY, Fu JM. 2004. Analysis of DNA methylation by tandem ion-pair reversed-phase high-performance liquid chromatography/electrospray ionization mass spectrometry. Rapid Commun Mass Spectrom 18:2773-2778.
6. Gao A, Zuo X, Liu QJ, Lu X, Guo W, Tian L. 2010. Methylation of PARP-1 promoter involved in the regulation of benzene-induced decrease of PARP-1 mRNA expression. Toxicol Lett 1952-3:114-118.
7. Gaskell M, McLuckie KIE, Farmer PB. 2005. Genotoxicity of the benzene metabolites para-benzoquinone and hydroquinone. Chem Biol Interact 153:267-270.
8. Gaudet F, Hodgson JG, Eden A, Jackson-Grusby L, Dausman J, Gray JW, Leonhardt H, Jaenisch R. 2003. Induction of tumors in mice by genomic hypomethylation. Science 300:489-492.
9. Hu JJ, Ma HM, Zhang WB, Cai YM, Yu ZQ, Sheng GY, Fu JM. 2010. Effects of an acute exposure of benzene on DNA methylation in Sprague-Dawley rats. Ecol Environ.19:2902-2905.
10. IARC. 1987. IARC monographs on the evaluation of carcinogenic risks to humans.Supplement/World Health Organization, International Agency for Research on Cancer. France.1-42:120-122.
11. Jeltsch A. 2002. Beyond Watson and Crick: DNA methylation and molecular enzymology of DNA methyltransferases. Chembiochem 35:382-382.
12. Ji Z, Zhang L, Peng V, Ren X, McHale CM, Smith MT. 2010. A comparison of the cytogenetic alterations and global DNA hypomethylation induced by the benzene metabolite, hydroquinone, with those induced by melphalan and etoposide. Leukemia 245:986-991.
13. Kuang SQ, Tong WG, Yang H, Lin W, Lee MK, Fang ZH, Wei Y, Jelinek J, Issa JP, Garcia-Manero G. 2008. Genome-wide identification of aberrantly methylated promoter associated CpG islands in acute lymphocytic leukemia DNA Methylation in ALL. Leukemia 22:1529-1538.
14. Kuo KC, McCune RA, Gehrke CW, Midgett R, Ehrlich M. 1980. Quantitative reversed-phase high-performance liquid-chromatographic determination of major and modified deoxyribonucleosides in DNA. Nucleic Acids Res 820:4763-4776.
15. Levay G, Pongracz K, Bodell WJ. 1991. Detection of DNA adducts in HL-60 cells treated with hydroquinone and para-benzoquinone by P-32 postlabeling. Carcinogenesis 127:1181-1186.
16. Ma HM, Zhang WB, Song RF, Zhou Z, Chen HY, Sheng GY, Zhou Z, Fu JM. 2005. Characterization of methylated and unmethylated CpG oligodeoxynucleotides by electrospray ionization tandem mass spectrometry. Eur J Mass Spectrom 116:581-589.
17. Ma HM, Zhang WB, Hu JJ, Yu ZQ, Chen Y, Luo Q, Shi XL, Zhang YY, Song RF, Zhou Z, Sheng GY, Fu JM. 2009. Analysis of global DNA methylation levels in human blood using high-performance liquid chromatography/tandem electrospray ionization mass spectrometry. Eur J Mass Spectrom 154:555-561.
18. Maltseva DV, Baykov AA, Jeltsch A, Gromova ES. 2009. Impact of 7, 8-dihydro-8-oxoguanine on methylation of the CpG site by Dnmt3a. Biochemistry 486:1361-1368.
19. Muller CI, Luong QT, Shih LY, Jones LC, Desmond JC, Kawamata N, Tcherniantchouk O, Liu Q, Ito Y, Tefferi A, Vos SD, Koeffler HP. 2008. Identification of marker genes including RUNX3 AML2 that discriminate between different myeloproliferative neoplasms and normal individuals. Leukemia 229:1773-1778.
20. 32postlabeling of DNA reacted with para-benzoquinone. Chem Res Toxicol 42:199-202.
21. 4-benzetheno-2′-deoxycytidine-3′-phosphate by p-32 postlabeling of DNA reacted with p-benzoquinone. Carcinogenesis 119:1469-1472.
22. Rappaport SM, Kim S, Lan Q, Vermeulen R, Waidyanatha S, Zhang LP, Li GL, Yin SN, Hayes RB, Rothman N, Smith MT. 2009. Evidence that humans metabolize benzene via two pathways. Environ Health Perspect 1176:946-952.
23. Schnatter AR, Rosamilia K, Wojcik NC. 2005. Review of the literature on benzene exposure and leukemia subtypes. Chem Biol Interact 153:9-21.
24. Singer J, Schnute WC, Shively JE, Todd CW, Riggs AD. 1979. Sensitive detection of 5-methylcytosine and quantitation of the 5-methylcytosine-cytosine ration in DNA by gas chromatography ion monitoring. Anal Biochem 942:297-301.
25. Song LG, James SR, Kazim L, Karpf AR. 2005. Specific method for the determination of genomic DNA methylation by liquid chromatography electrospray ionization tandem mass spectrometry. Anal Chem 77:504-510.
26. Subach OM, Baskunov VB, Darii MV, Maltseva DV, Kirsanova OV, Kolbanovskiy A, Kolbanovskiy M, Johnson F, Bonala R. 2006. Impact of benzo [a] pyrene-2-deoxyguanosine lesions on methylation of DNA by SssI and HhaI DNA methyltransferases. Biochemistry 45:6142-6159.
27. Wan J, Winn LM. 2007. Benzene's metabolites alter c-MYB activity via reactive oxygen species in HD3 cells. Toxicol Appl Pharmacol 2222:180-189.
28. Xing C, Wang QF, Li B, Tian H, Ni Y, Yin S, Li G. 2010. Methylation and expression analysis of tumor suppressor genes p15 and p16 in benzene poisoning. Chem Biol Interact 184:306-309.
29. Zhang LP, McHale CM, Rothman N, Li GL, Ji ZY, Vermeulen R, Hubbard AE, Ren XF, Shen M, Rappaport SM, North M, Skibola CF, Yin SN, Vulpe C, Chanock SJ, Smith MT, Lan Q. 2010. Systems biology of human benzene exposure. Chem Biol Interact 1841-2:86-93.