Reduced in vitro and in vivo toxicity of siRNA-lipoplexes with addition of polyglutamate

Journal of Controlled Release

Volumn 165, Issue 1, 2013, Pages 1-8

  Schlegel, Anne ^a,b,c,d   Bigey, Pascal ^a,b,c,d   Dhotel, Hélène ^a,b,c,d   Scherman, Daniel ^a,b,c,d   Escriou, Virginie ^a,b,c,d,e  

^a CNRS   (France)

^b Centre National de la Recherche Scientifique   (France)

^c UNIVERSITÉ PARIS DESCARTES   (France)

^d PSL RESEARCH UNIVERSITY   (France)

^e DNA Therapeutics   (France)

Author keywords

Anionic polymers; Cationic lipid; Gene silencing; Lipoplexes; RNA interference; siRNA

Indexed keywords

ANIONIC POLYMERS; CATIONIC LIPIDS; GENE SILENCING; LIPOPLEXES; RNA INTERFERENCE; SIRNA;

BIOMOLECULES; CELL CULTURE; CELL DEATH; COMPLEXATION; DNA; GENETIC ENGINEERING; LIPOSOMES; MAMMALS; RNA; TOXICITY;

POLYMERS;

ALANINE AMINOTRANSFERASE; ALPHA INTERFERON; BETA INTERFERON; GAMMA INTERFERON; GENOMIC DNA; INTERLEUKIN 6; LIPOPLEX; LIPOSOME; OLIGONUCLEOTIDE; PLASMID DNA; POLYGLUTAMIC ACID; POLYINOSINIC POLYCYTIDYLIC ACID; SMALL INTERFERING RNA; TRANSFER RNA; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; CPG ISLAND; CYTOKINE RELEASE; CYTOTOXICITY; FEMALE; GENE DELIVERY SYSTEM; GENETIC TRANSFECTION; IN VITRO STUDY; IN VIVO STUDY; LIVER TOXICITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; TOXICITY TESTING; TUMOR CELL LINE;

ALANINE TRANSAMINASE; ANIMALS; APOPTOSIS; CELL LINE; CELL SURVIVAL; DNA; FEMALE; GENE SILENCING; LIPOSOMES; LUCIFERASES; MICE; MICE, INBRED C57BL; PLASMIDS; POLYGLUTAMIC ACID; RNA, SMALL INTERFERING; TRANSFECTION;

EID: 84869866156     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2012.10.018     Document Type: Article

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