Evaluation of proinflammatory cytokine production and liver injury induced by plasmid DNA/cationic liposome complexes with various mixing ratios in mice

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 71, Issue 2, 2009, Pages 303-309

  Ito, Yoshitaka ^a   Kawakami, Shigeru ^a   Charoensit, Pensri ^a   Higuchi, Yuriko ^a   Hashida, Mitsuru ^a  

^a KYOTO UNIVERSITY   (Japan)

Author keywords

Cationic lipids; Cytokine; Lipoplexes; Liver injury; Plasmid DNA

Indexed keywords

1,2 DIOLEOYL 3 TRIMETHYLAMMONIOPROPANE; ALANINE AMINOTRANSFERASE; CHOLESTEROL; CYTOKINE; LIPOSOME; LUCIFERASE; PLASMID DNA; TUMOR NECROSIS FACTOR ALPHA;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CYTOKINE PRODUCTION; ENZYME ACTIVITY; EVALUATION; FEMALE; GENETIC TRANSFECTION; INFLAMMATION; LIPOSOMAL GENE DELIVERY SYSTEM; LIVER INJURY; MOUSE; NONHUMAN;

ALANINE TRANSAMINASE; ANIMALS; CATIONS; CHOLESTEROL; CYTOKINES; DNA; FATTY ACIDS, MONOUNSATURATED; FEMALE; GENE DOSAGE; GENE TRANSFER TECHNIQUES; INFLAMMATION MEDIATORS; INJECTIONS, INTRAVENOUS; LIPOSOMES; LIVER; LUCIFERASES; MICE; MICE, INBRED ICR; PLASMIDS; QUATERNARY AMMONIUM COMPOUNDS; TRANSFECTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 59649128201     PISSN: 09396411     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejpb.2008.09.005     Document Type: Article

References (26)

1. Zhu N., Liggitt D., Liu Y., and Debs R. Systemic gene expression after intravenous DNA delivery into adult mice. Science 261 (1993) 209-211
2. Liu F., Qi H., Huang L., and Liu D. Factors controlling the efficiency of cationic lipid mediated transfection in vivo via intravenous administration. Gene Ther. 4 (1997) 517-523
3. Song Y.K., Liu F., and Liu D. Enhanced gene expression in mouse lung by prolonging the retention time of intravenously injected plasmid DNA. Gene Ther. 5 (1998) 1531-1537
4. Dow S., Elmslie R., Kurzman I., Macewen G., Pericle F., and Liggitt D. Phase I study of liposome-DNA complexes encoding the interleukin-2 gene in dogs with osteosarcoma lung metastases. Hum. Gene Ther. 16 (2005) 937-946
5. Li S., and Huang L. In vivo gene transfer via intravenous administration of cationic lipid- protamine-DNA (LPD) complexes. Gene Ther. 4 (1997) 891-900
6. Tousignant J.D., Zhao H., Yew N.S., Cheng S.H., Eastman S.J., and Scheule R.K. Comprehensive analysis of the acute toxicities induced by systemic administration of cationic lipid: plasmid DNA complexes in mice. Hum. Gene Ther. 11 (2000) 2493-2513
7. Loisel S., Gall C.L., Doucet L., Ferec C., and Floch V. Contribution of plasmid DNA to hepatotoxicity after systemic administration of lipoplexes. Hum. Gene Ther. 12 (2001) 685-696
8. Sakurai F., Terada T., Yasuda K., Yamashita F., Takakura Y., and Hashida M. The role of tissue macrophages in the induction of proinflammatory cytokine production following intravenous injection of lipoplexes. Gene Ther. 9 (2002) 1120-1126
9. Liu F., Shollenberger L.M., and Huang L. Non-immunostimulatory nonviral vectors. FASEB J. 18 (2004) 1779-1781
10. Sakurai H., Sakurai F., Kawabata K., Sasaki T., Koizumi N., Huang H., Tashiro K., Kurachi S., Nakagawa S., and Mizuguchi H. Comparison of gene expression efficiency and innate immune response induced by Ad vector and lipoplex. J. Control. Release 117 (2007) 430-437
11. Huang L., and Li S. Liposomal gene delivery: a complex package. Nat. Biotechnol. 15 (1997) 620-621
12. Li S., Wu S.P., Whitmore M., Loeffert E.J., Wang L., Watkins S.C., Pitt B.R., and Huang L. Effect of immune response on gene transfer to the lung via systemic administration of cationic lipidic vectors. Am. J. Physiol. 276 (1999) L796-804
13. Higuchi Y., Kawakami S., Nishikawa M., Yamashita F., and Hashida M. Intracellular distribution of NFκB decoy and its inhibitory effect on TNFα production by LPS stimulated RAW 264.7 cells. J. Control. Release 107 (2005) 373-382
14. Kawakami S., Ito Y., Charoensit P., Yamashita F., and Hashida M. Evaluation of proinflammatory cytokine production induced by linear and branched polyethylenimine/plasmid DNA complexes in mice. J. Pharmacol. Exp. Ther. 317 (2006) 1382-1390
15. Tan Y., Li S., Pitt B.R., and Huang L. The inhibitory role of CpG immunostimulatory motifs in cationic lipid vector-mediated transgene expression in vivo. Hum. Gene Ther. 10 (1999) 2153-2161
16. Shigeta K., Kawakami S., Higuchi Y., Okuda T., Yagi H., Yamashita F., and Hashida M. Novel histidine-conjugated galactosylated cationic liposomes for efficient hepatocyte-selective gene transfer in human hepatoma HepG2 cells. J. Control. Release 118 (2007) 262-270
17. Kawakami S., Ito Y., Fumoto S., Yamashita F., and Hashida M. Enhanced gene expression in lung by a stabilized lipoplex using sodium chloride for complex formation. J. Gene Med. 7 (2005) 1526-1533
18. Lv H., Zhang S., Wang B., Cui S., and Yan J. Toxicity of cationic lipids and cationic polymers in gene delivery. J. Control. Release 114 (2006) 100-109
19. Sester D.P., Naik S., Beasley S.J., Hume D.A., and Stacey K.J. Phosphorothioate backbone modification modulates macrophage activation by CpG DNA. J. Immunol. 165 (2000) 4165-4173
20. Krieg A.M., Yi A.K., Matson S., Waldschmidt T.J., Bishop G.A., Teasdale R., and Koretzky G.A. CpG motifs in bacterial DNA trigger direct B-cell activation. Nature 374 (1995) 546-549
21. Zhao H., Hemmi H., Akira S., Cheng S.H., Scheule R.K., and Yew N.S. Contribution of Toll-like receptor 9 signaling to the acute inflammatory response to nonviral vectors. Mol. Ther. 9 (2004) 241-248
22. Song Y.K., Liu F., Chu S., and Liu D. Characterization of cationic liposome-mediated gene transfer in vivo by intravenous administration. Hum. Gene Ther. 8 (1997) 1585-1594
23. Kim H.S., Song I.H., Kim J.C., Kim E.J., Jang D.O., and Park Y.S. In vitro and in vivo gene-transferring characteristics of novel cationic lipids, DMKD (O,O′-dimyristyl-N-lysyl aspartate) and DMKE (O,O'-dimyristyl-N-lysyl glutamate). J. Control. Release 115 (2006) 234-241
24. Wasungu L., and Hoekstra D. Cationic lipids, lipoplexes and intracellular delivery of genes. J. Control. Release 116 (2006) 255-264
25. Whitmore M., Li S., and Huang L. LPD lipopolyplex initiates a potent cytokine response and inhibits tumor growth. Gene Ther. 6 (1999) 1867-1875
26. Yew N.S., Zhao H., Przybylska M., Wu I.H., Tousignant J.D., Scheule R.K., and Cheng S.H. CpG-depleted plasmid DNA vectors with enhanced safety and long-term gene expression in vivo. Mol. Ther. 5 (2002) 731-738