Developing NKT cells need their (E) protein

Immunology and Cell Biology

Volumn 88, Issue 5, 2010, Pages 507-509

  Chan, Angela C ^a   Berzins, Stuart P ^a   Godfrey, Dale I ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; CHEMOKINE RECEPTOR CXCR6; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN HELA E BOX; T LYMPHOCYTE RECEPTOR ALPHA CHAIN; T LYMPHOCYTE RECEPTOR BETA CHAIN; TRANSCRIPTION FACTOR E2A; UNCLASSIFIED DRUG; TCF12 PROTEIN, MOUSE;

ANTIGEN PRESENTING CELL; CELL FUNCTION; CELL MATURATION; CELL PROLIFERATION; CELL SELECTION; CELL SURVIVAL; DOWN REGULATION; GENE REARRANGEMENT; NATURAL KILLER T CELL; NONHUMAN; NOTE; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FUNCTION; REGULATORY MECHANISM; T LYMPHOCYTE RECEPTOR GENE; TCR J ALPHA18 GENE; TCR V ALPHA14 GENE; THYMOCYTE; TRANSCRIPTION INITIATION; UPREGULATION; ANIMAL; CELL DIFFERENTIATION; CYTOLOGY; GENETIC TRANSCRIPTION; HUMAN; IMMUNOLOGY; METABOLISM; STEM CELL;

ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CELL DIFFERENTIATION; HUMANS; NATURAL KILLER T-CELLS; STEM CELLS; TRANSCRIPTION, GENETIC;

EID: 77954315321     PISSN: 08189641     EISSN: 14401711     Source Type: Journal    
DOI: 10.1038/icb.2010.55     Document Type: Note

References (16)

1. Bendelac A, Savage PB, Teyton L. The biology of NKT cells. Annu Rev Immunol 2007; 25: 297-336.
2. Godfrey DI, Stankovic S, Baxter AG. Raising the NKT cell family. Nat Immunol 2010; 11: 197-206.
3. D'Cruz LM, Knell J, Fujimoto JK, Goldrath AW. An essential role for the transcription factor HEB in thymocyte survival, Tcra rearrangement and the development of natural killer T cells. Nat Immunol 2010; 11: 240-249.
4. Murre C. Helix-loop-helix proteins and lymphocyte development. Nat Immunol 2005; 6: 1079-1086.
5. Kee BL. E and ID proteins branch out. Nat Rev Immunol 2009; 9: 175-184.
6. Wojciechowski J, Lai A, Kondo M, Zhuang Y. E2A and HEB are required to block thymocyte proliferation prior to pre-TCR expression. J Immunol 2007; 178: 5717-5726.
7. Barndt RJ, Dai M, Zhuang Y. Functions of E2A-HEB heterodimers in T-cell development revealed by a dominant negative mutation of HEB. Mol Cell Biol 2000; 20: 6677-6685.
8. Barndt R, Dai MF, Zhuang Y. A novel role for HEB downstream or parallel to the pre-TCR signaling pathway during alpha beta thymopoiesis. J Immunol 1999; 163: 3331-3343.
9. Bain G, Engel I, Robanus Maandag EC, te Riele HP, Voland JR, Sharp LL et al. E2A deficiency leads to abnormalities in alphabeta T-cell development and to rapid development of T-cell lymphomas. Mol Cell Biol 1997; 17: 4782-4791.
10. Monticelli LA, Yang Y, Knell J, D'Cruz LM, Cannarile MA, Engel I et al. Transcriptional regulator Id2 controls survival of hepatic NKT cells. Proc Natl Acad Sci USA 2009; 106: 19461-19466.
11. Godfrey DI, Berzins SP. Control points in NKT-cell development. Nat Rev Immunol 2007; 7: 505-518.
12. Guo J, Hawwari A, Li H, Sun Z, Mahanta SK, Littman DR et al. Regulation of the TCRalpha repertoire by the survival window of CD4(+)CD8(+) thymocytes. Nat Immunol 2002; 3: 469-476.
13. Egawa T, Eberl G, Taniuchi I, Benlagha K, Geissmann F, Hennighausen L et al. Genetic evidence supporting selection of the Valpha14i NKT cell lineage from double-positive thymocyte precursors. Immunity 2005; 22: 705-716.
14. Hager E, Hawwari A, Matsuda JL, Krangel MS, Gapin L. Multiple constraints at the level of TCRalpha rearrangement impact Valpha14i NKT cell development. J Immunol 2007; 179: 2228-2234.
15. Godfrey DI, MacDonald HR, Kronenberg M, Smyth MJ, Van Kaer L. NKT cells: what's in a name? Nat Rev Immunol 2004; 4: 231-237.
16. Park SH, Weiss A, Benlagha K, Kyin T, Teyton L, Bendelac A. The mouse CD1d-restricted repertoire is dominated by a few autoreactive T cell receptor families. J Exp Med 2001; 193: 893-904.